GSK1349572 (Dolutegravir): Selectivity & Specificity

GSK1349572 (Dolutegravir) is a potent inhibitor of GSK-3β (< 500 nM), Recombinant human MMP-1 (83.93 µM), Recombinant human MMP-2 (16.89 µM), Recombinant human MMP-3 (60.30 µM), Recombinant human MMP-7 (308.76 µM), Recombinant human MMP-8 (12.08 µM), Recombinant human MMP-9 (11.05 µM), Recombinant human MMP-12 (131.37 µM), Recombinant human MMP-13 (36.53 µM), Recombinant human MMP-14 (10.52 µM), and Recombinant human MMP-19 (54.0 µM). GSK1349572 (Dolutegravir) exhibits the greatest inhibitory potency toward GSK-3β (IC50 = < 500 nM).