CAS No. 115956-12-2
Batch:
Purity:99.89
Chemical Structure
Check the
Dolasetron
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 115956-12-2 | |
|---|---|---|
| Molecular Formula |
C19H20N2O3 |
|
| Molecular Weight (MW) | 324.37 | |
| SMILES | C1C2CC3CC(CC1N3CC2=O)OC(=O)C4=CNC5=CC=CC=C54 |
Dolasetron (MDL-73147EF) is a highly specific and selective serotonin 5-HT3 receptor antagonist. It exhibits minimal binding affinity for other serotonin receptor subtypes as well as dopamine receptors. By selectively blocking 5-HT3 receptors, dolasetron inhibits serotonin-mediated depolarization of peripheral vagal afferent nerves and central chemoreceptor trigger zones, thereby suppressing downstream emetic signaling pathways and cellular depolarization responses.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
64 mg/mL
(197.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.