CAS No. 115956-13-3
Batch:
Purity:98.44
Chemical Structure
Check the
Dolasetron Mesylate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 115956-13-3 | |
|---|---|---|
| Molecular Formula |
C20H24N2O6S |
|
| Molecular Weight (MW) | 420.48 | |
| SMILES | CS(=O)(=O)O.C1C2CC3CC(CC1N3CC2=O)OC(=O)C4=CNC5=CC=CC=C54.O |
Biological Activity
Dolasetron mesylate is a serotonin 5-HT3 receptor antagonist. By selectively blocking 5-HT3 receptors on peripheral vagal nerve terminals and centrally in the chemoreceptor trigger zone, it inhibits serotonin-mediated signaling in the central and peripheral nervous systems. This receptor blockade suppresses emetic signal transmission and inhibits the reflex pathway, thereby preventing chemotherapy-induced nausea and vomiting responses in cellular and preclinical models.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
84 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 28 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.