CAS No. 89464-63-1

Batch: Purity:99.92
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DMOG (Dimethyloxallyl Glycine) Chemical Structure
Chemical Structure
Check the DMOG (Dimethyloxallyl Glycine) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name methyl 2-[(2-methoxy-2-oxoethyl)amino]-2-oxoacetate
CAS Number 89464-63-1
Molecular Formula

C6H9NO5
Molecular Weight (MW) 175.14
SMILES COC(=O)CNC(=O)C(=O)OC
InChIKey BNJOZDZCRHCODO-UHFFFAOYSA-N

Ordering Information

Biological Activity

DMOG (Dimethyloxalylglycine) is a cell-permeable competitive antagonist of the α-ketoglutarate cofactor and an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PHD). By inhibiting prolyl hydroxylase activity, DMOG prevents the degradation of HIF-1α, leading to its stabilization and nuclear accumulation. This response activates downstream hypoxia-responsive gene expression, regulating cellular adaptation to hypoxic conditions and promoting autophagy. [1][2]

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 35 mg/mL (199.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 35 mg/mL
Ethanol 35 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.