CAS No. 5072-26-4

Batch: Purity:100.00
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DL-Buthionine-Sulfoximine Chemical Structure
Chemical Structure
Check the DL-Buthionine-Sulfoximine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-amino-4-(butylsulfonimidoyl)butanoic acid
CAS Number 5072-26-4
Molecular Formula

C8H18N2O3S
Molecular Weight (MW) 222.31
SMILES CCCCS(=N)(=O)CCC(C(=O)O)N
InChIKey KJQFBVYMGADDTQ-UHFFFAOYSA-N

Ordering Information

Biological Activity

DL-Buthionine-Sulfoximine is a specific inhibitor of glutathione synthesis that acts by targeting glutamate-cysteine ligase (gamma-glutamylcysteine synthetase). By depleting intracellular glutathione pools, it impairs cellular antioxidant defense mechanisms and increases cellular sensitivity to oxidative stress. Consequently, depletion of glutathione alters redox-sensitive signalling pathways and promotes reactive oxygen species-mediated apoptotic cell death in various experimental models. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 44 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.