CAS No. 65836-72-8
Batch:
Purity:99.49
Chemical Structure
Check the
DKM 2-93
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-chloro-N-[(3,4-dimethoxyphenyl)methyl]acetamide | |
|---|---|---|
| CAS Number | 65836-72-8 | |
| Molecular Formula |
C11H14ClNO3 |
|
| Molecular Weight (MW) | 243.69 | |
| SMILES | COC1=C(C=C(C=C1)CNC(=O)CCl)OC | |
| InChIKey | CETPWRGZGWGPSV-UHFFFAOYSA-N |
DKM 2-93 is a selective small-molecule inhibitor targeting ubiquitin-like modifier activating enzyme 5 (UBA5). By selectively inhibiting UBA5 enzyme activity, the compound disrupts the cascade of UFMylation, impairing downstream protein modification pathways critical for maintaining cellular homeostasis. Attenuation of UBA5-mediated UFM1 conjugation leads to altered endoplasmic reticulum stress responses and downstream cellular signaling phenotypes. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
49 mg/mL
(201.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 14 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.