Disodium (R)-2-Hydroxyglutarate: Selectivity & Specificity

Disodium (R)-2-Hydroxyglutarate is a potent inhibitor of JMJD-containing histone demethylases (JMJD2A, JMJD2C, FBXL11) (100000 nM), TET2, JmjC, EGLN, ALKBH2, ALKBH3, BCAT1, BCAT2, FTO, Cytochrome c oxidase, ATP synthase, SDH, ODC1, TET1, TET3, KDM4A, KDM4B, PLOD1, PLOD3, P4HA1, P4HA3, FIH. Disodium (R)-2-Hydroxyglutarate exhibits the greatest inhibitory potency toward JMJD-containing histone demethylases (JMJD2A, JMJD2C, FBXL11) (IC50 = 100000 nM).