CAS No. 4673-26-1

Batch: Purity:99.69
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DPI (Diphenyleneiodonium chloride) Chemical Structure
Chemical Structure
Check the DPI (Diphenyleneiodonium chloride) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 8-iodoniatricyclo[7.4.0.02,7]trideca-1(13),2,4,6,9,11-hexaene chloride
CAS Number 4673-26-1
Molecular Formula

C12H8I.Cl
Molecular Weight (MW) 314.55
SMILES C1=CC=C2C(=C1)C3=CC=CC=C3[I+]2.[Cl-]
InChIKey FCFZKAVCDNTYID-UHFFFAOYSA-M

Ordering Information

Biological Activity

DPI (Diphenyleneiodonium chloride) is an inhibitor of NADPH oxidase and functions as an irreversible, time- and temperature-dependent inhibitor of inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS). It also acts as a TRPA1 activator and selectively suppresses intracellular reactive oxygen species (ROS) accumulation. By targeting these enzyme complexes, DPI modulates downstream oxidative stress signaling pathways and attenuates cellular inflammatory phenotypes. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 13 mg/mL (41.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.