CAS No. 624-49-7
Batch:
Purity:100.00
Chemical Structure
Check the
DMF (Dimethyl Fumarate)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | dimethyl (E)-but-2-enedioate | |
|---|---|---|
| CAS Number | 624-49-7 | |
| Molecular Formula |
C6H8O4 |
|
| Molecular Weight (MW) | 144.13 | |
| SMILES | COC(=O)C=CC(=O)OC | |
| InChIKey | LDCRTTXIJACKKU-ONEGZZNKSA-N |
DMF (Dimethyl Fumarate) is a methyl ester derivative of fumaric acid that functions as a nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway activator. Activation of the Nrf2 pathway by DMF induces the transcription and upregulation of downstream cytoprotective antioxidant genes. This activation decreases oxidative stress and attenuates neuroinflammatory and neurodegenerative responses in cellular and animal models of disease. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
29 mg/mL
(201.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 29 mg/mL |
| Water | Insoluble |
| DMSO |
29 mg/mL
(201.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 14 mg/mL |
| Water | Insoluble |
| DMSO |
29 mg/mL
(201.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
| DMSO |
29 mg/mL
(201.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
| DMSO |
29 mg/mL
(201.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 29 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- DMF (Dimethyl Fumarate) Clinical Trials
- DMF (Dimethyl Fumarate) Solubility in DMSO
- DMF (Dimethyl Fumarate) Stock Solution
- DMF (Dimethyl Fumarate) Storage
- DMF (Dimethyl Fumarate) Stability
- DMF (Dimethyl Fumarate) Molecular Weight
- DMF (Dimethyl Fumarate) SMILES
- DMF (Dimethyl Fumarate) Chemical Structure (2D and 3D)
- DMF (Dimethyl Fumarate) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.