CAS No. 151358-47-3
Batch:
Purity:97.53
Chemical Structure
Check the
DIM-C-pPhOH
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[bis(1H-indol-3-yl)methyl]phenol | |
|---|---|---|
| CAS Number | 151358-47-3 | |
| Molecular Formula |
C23H18N2O |
|
| Molecular Weight (MW) | 338.40 | |
| SMILES | C1=CC=C2C(=C1)C(=CN2)C(C3=CC=C(C=C3)O)C4=CNC5=CC=CC=C54 | |
| InChIKey | QCPDFNWJBQMXLI-UHFFFAOYSA-N |
DIM-C-pPhOH is a nuclear receptor 4A1 (NR4A1/Nur77) antagonist that inhibits cell proliferation in renal cell carcinoma ACHN and 786-O cells. By antagonizing NR4A1, DIM-C-pPhOH suppresses downstream mTOR signaling, triggers cellular stress responses, and induces apoptosis. These pathway alterations block tumor cell growth and attenuate overall tumor progression in cancer models.
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
200 mg/mL
(591.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 68 mg/mL |
| Water | Insoluble |
| DMSO |
68 mg/mL
(200.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 68 mg/mL |
| Water | Insoluble |
| DMSO |
68 mg/mL
(200.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 68 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.