CAS No. 20830-75-5
Batch:
Purity:99.61
Chemical Structure
Check the
Digoxin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 20830-75-5 | |
|---|---|---|
| Molecular Formula |
C41H64O14 |
|
| Molecular Weight (MW) | 780.94 | |
| SMILES | CC1C(C(CC(O1)OC2C(OC(CC2O)OC3C(OC(CC3O)OC4CCC5(C(C4)CCC6C5CC(C7(C6(CCC7C8=CC(=O)OC8)O)C)O)C)C)C)O)O |
Biological Activity
Digoxin is a classic Na+/K+-ATPase inhibitor that displays selectivity for the α2β3 isoform over the α1β1 isoform. Inhibition of membrane Na+/K+-ATPase disrupts transmembrane sodium and potassium homeostasis, which alters downstream intracellular calcium signaling pathways. Furthermore, Digoxin represses HIF-1α protein synthesis to downregulate hypoxia-inducible gene expression, thereby impairing tumor cell vascularization, survival, and cellular proliferation under hypoxic conditions. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(128.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.