Diethyl malonate SDS/MSDS (Safety Data Sheet)

3.1 Substances
Product name: Diethyl malonate
CAS Number: 105-53-3
PubChem CID: 7761
Molecular formula: C7H12O4
Molecular weight: 160.17 g/mol
IUPAC name: diethyl propanedioate

3.2 Mixtures
Not applicable (pure substance).

4.1 Description of first aid measures
Inhalation: Fresh air, rest. Seek medical attention if you feel unwell.
Skin contact: Rinse and then wash skin with water and soap.
Eye contact: First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion: Give one or two glasses of water to drink. Seek medical attention if you feel unwell.

4.2 Most important symptoms and effects, both acute and delayed
See Section 11 (Toxicological Information).

4.3 Indication of any immediate medical attention and special treatment needed
Treat symptomatically. Contact a poison control center or physician for severe exposure.

5.1 Extinguishing media
Suitable: Water spray, dry chemical, carbon dioxide (CO2), alcohol-resistant foam.
Unsuitable: None known.

5.2 Specific hazards arising from the substance or mixture
Use carbon dioxide, dry powder, water spray, foam. In case of fire: keep drums, etc., cool by spraying with water.
Water may be used to blanket fire.
To fight fire, use water to blanket fire, foam, CO2, dry chemical.
Extinguishing media: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary. Further information: Use water spray to cool unopened containers.

5.3 Advice for firefighters
Wear self-contained breathing apparatus (SCBA) and full protective clothing.
Fight fire from upwind. Cool containers with water spray until fire is extinguished.
Flash point: 200 °F (93 °C) (open cup)

6.1 Personal precautions, protective equipment and emergency procedures
Wear appropriate personal protective equipment (see Section 8).
Avoid breathing dust/vapor. Ensure adequate ventilation.
Evacuate personnel to safe areas. Keep people away from and upwind of spill.

6.2 Environmental precautions
Prevent product from entering drains, waterways, or soil.
Contain spill with inert absorbent material.

6.3 Methods and materials for containment and cleaning up
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.
ACCIDENTAL RELEASE MEASURES; Personal precautions, protective equipment and emergency procedures: Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations. Keep in suitable, closed containers for disposal.
SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.
Product: This combustible material may be burned in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company. Contaminated packaging: Dispose of as unused product.
Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
Avoid inhalation of vapor or mist. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.
ACCIDENTAL RELEASE MEASURES; Personal precautions, protective equipment and emergency procedures: Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

7.1 Precautions for safe handling
Separated from strong oxidants. Ventilation along the floor. Store in an area without drain or sewer access.
Keep container tightly closed in a dry and well-ventilated place.

7.2 Conditions for safe storage, including any incompatibilities
Separated from strong oxidants. Ventilation along the floor. Store in an area without drain or sewer access.
Keep container tightly closed in a dry and well-ventilated place.
Store away from incompatible materials (see Section 10).
[Note: Specific storage temperature not available in public databases. Refer to supplier Certificate of Analysis (COA) for exact storage conditions.]
Store in original container. Keep upright to prevent leakage.

9.1 Information on basic physical and chemical properties
a) Appearance: Liquid; Other Solid; Liquid
b) Odor: Sweet ester odor
c) Odor threshold: No data available
d) pH: No data available
e) Melting point/freezing point: -50 °C
f) Initial boiling point and boiling range: 200 °C
g) Flash point: 200 °F (93 °C) (open cup)
h) Evaporation rate: No data available
i) Flammability (solid, gas): No data available
j) Upper/lower flammability or explosive limits: No data available
k) Vapor pressure: 0.26 [mmHg]
l) Vapor density: No data available
m) Relative density: 1.0551 g/cu cm at 20 °C
n) Water solubility: In water, 20 g/L at 20 °C
o) Partition coefficient: n-octanol/water: Log P (n-octanol/water): 1
p) Auto-ignition temperature: 435 °C
q) Decomposition temperature: No data available
r) Viscosity: 1.86 centistokes at 25 °C
s) Explosive properties: No data available
t) Oxidizing properties: No data available

9.2 Other information
Topological Polar Surface Area (TPSA): 52.6 Ų
Complexity: 125

11.1 Information on toxicological effects
Acute toxicity:
No acute toxicity data available.
Skin corrosion/irritation:
No data available.
Serious eye damage/eye irritation:
Causes serious eye irritation (H319).
Respiratory or skin sensitization:
No data available.
Germ cell mutagenicity:
No data available.
Carcinogenicity:
No data available.
Reproductive toxicity:
No data available.
Specific target organ toxicity (single exposure):
No data available.
Specific target organ toxicity (repeated exposure):
No data available.
Aspiration hazard:
No data available.

11.2 Additional information
Signs and symptoms of exposure:
Cough.
Redness.
Redness.
No acute symptoms expected.
Data source: Hazardous Substances Data Bank (HSDB) via PubChem.

12.1 Toxicity
EC50; Species: Pimephales promelas (Fathead Minnow) age 33 days, length 14 mm, weight 0.036 g; Conditions: freshwater, flow through, 25.4 °C (23.5-27.7 °C), pH 7.42 (7.35-7.45), hardness 44.0 mg/L CaCO3, alkalinity 45.0 mg/L CaCO3, dissolved oxygen 87.6 mg/L (73.7-102 mg/L); Concentration: 20900 ug/L for 24 hr; Effect: behavior, loss of equilibrium /99% purity/
EC50; Species: Pimephales promelas (Fathead Minnow) age 33 days, length 14 mm, weight 0.036 g; Conditions: freshwater, flow through, 25.4 °C (23.5-27.7 °C), pH 7.42 (7.35-7.45), hardness 44.0 mg/L CaCO3, alkalinity 45.0 mg/L CaCO3, dissolved oxygen 87.6 mg/L (73.7-102 mg/L); Concentration: 15600 ug/L for 48 hr; Effect: behavior, loss of equilibrium /99% purity/
LC50; Species: Pimephales promelas (Fathead Minnow) age 33 days, length 14 mm, weight 0.036 g; Conditions: freshwater, flow through, 25.4 °C (23.5-27.7 °C), pH 7.42 (7.35-7.45), hardness 44.0 mg/L CaCO3, alkalinity 45.0 mg/L CaCO3, dissolved oxygen 87.6 mg/L (73.7-102 mg/L); Concentration: 23500 ug/L for 24 hr /99% purity/
LC50; Species: Pimephales promelas (Fathead Minnow) age 33 days, length 14 mm, weight 0.036 g; Conditions: freshwater, flow through, 25.4 °C (23.5-27.7 °C), pH 7.42 (7.35-7.45), hardness 44.0 mg/L CaCO3, alkalinity 45.0 mg/L CaCO3, dissolved oxygen 87.6 mg/L (73.7-102 mg/L); Concentration: 16600 ug/L for 48 hr /99% purity/
For more Ecotoxicity Values (Complete) data for Diethyl malonate (7 total), please visit the HSDB record page.
The substan

12.2 Persistence and degradability
No data available.

12.3 Bioaccumulative potential
Log P (n-octanol/water): 1
Low potential for bioaccumulation (Log P < 3).

12.4 Mobility in soil
No data available.

12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available.

12.6 Other adverse effects
This substance is classified as hazardous to the aquatic environment.

13.1 Waste treatment methods
Waste Treatment Methods: Waste material must be disposed of in accordance with national and local regulations. Leave chemicals in original containers and do not mix with other waste. Handle uncleaned containers in the same manner as the product itself.

14.1 UN number
Not regulated as dangerous goods (research quantities typically exempt).

14.2 UN proper shipping name
Not subject to transport regulations (small quantities for research use).

14.3 Transport hazard class(es)
Not classified as dangerous goods for transport (research quantities).

14.4 Packing group
Not applicable (not regulated as dangerous goods in typical research quantities).

14.5 Environmental hazards
Marine pollutant: No (not classified as environmentally hazardous per GHS).

14.6 Special precautions for user
Transport in original packaging. Ensure containers are tightly sealed.
For bulk or commercial quantities, consult applicable transport regulations (DOT, IATA, IMDG).

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable.

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
US EPA / TSCA: Subject to EPA TSCA regulations
EU ECHA / REACH: Registered (REACH Active)

SARA 302 Components:
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components:
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards:
Acute (short-term) health hazard
Environmental hazard
Fire hazard

Massachusetts Right To Know Components:
This material contains components subject to the Massachusetts Right to Know Act. See Section 2 for hazard classification.
Pennsylvania Right To Know Components:
This material contains components subject to the Pennsylvania Right to Know Act. See Section 2 for hazard classification.
New Jersey Right To Know Components:
This material contains components subject to the New Jersey Right to Know Act. See Section 2 for hazard classification.

California Prop. 65 Components:
This product does not contain any chemicals known to the State of California to cause cancer, birth defects, or any other reproductive harm.

Other regulatory listings:
- The Australian Inventory of Industrial Chemicals: Chemical: Propanedioic acid, diethyl ester
- EFSA Legal Basis: Regulation (EC) No 1831/2003 (amended)
- New Jersey Worker and Community Right to Know Act: The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

15.2 Chemical safety assessment
A chemical safety assessment has not been carried out for this substance.
For research-use-only compounds, no CSA is required under REACH Annex I.

Revision Date: 2026/09/09
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.