CAS No. 105-53-3
Batch:
Purity:
Chemical Structure
Check the
Diethyl malonate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 105-53-3 | |
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| Molecular Formula |
C7H12O4 |
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| Molecular Weight (MW) | 160.17 | |
| SMILES | CCOC(=O)CC(=O)OCC |
Diethyl malonate is a naturally occurring dicarboxylic acid ester and metabolic derivative that interacts with mitochondrial respiratory pathways. As an esterified derivative of malonate, it serves as a synthetic precursor and chemical probe to investigate mitochondrial complex II and succinate dehydrogenase activity. In cellular systems, malonate derivatives modulate mitochondrial electron transport, succinate accumulation, and downstream reactive oxygen species generation during metabolic stress. [1]
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All in vitro solubility values are batch-tested experimental data (non-literature values).
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Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.