Clinical Trials

Numerous clinical trials spanning Early Phase 1 through Phase 4 evaluate Dexmedetomidine HCl across diverse indications, including conscious sedation during bronchoscopy, postoperative pain, emergence delirium, anxiety, and attenuation of hemodynamic responses to endotracheal intubation. Sponsored by various academic medical centers and institutes, these studies encompass completed, active, recruiting, and not yet recruiting recruitment statuses. Ultimately, these investigations underscore the drug's clinical utility as a sedative and analgesic adjuvant in pediatric and surgical procedures.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07221539 RECRUITING
Mental Function
University of Michigan
 2025-10-24
NCT04443517 NOT_YET_RECRUITING
Postoperative Delirium
Columbia University
 2026-04-01
NCT07576543 NOT_YET_RECRUITING
Older Patients; Surgery; Dexmedetomidine; Esketamine; Transcranial Direct Current Stimulation; Cognitive Function; Survival
Peking University First Hospital
 2026-06 PHASE4
NCT06259565 RECRUITING
Non-Invasive Ventilation
St. Joseph's Healthcare Hamilton
 2025-07-29 PHASE3
NCT06468436 NOT_YET_RECRUITING
Aged; Intensive Care Units; Ventilators, Mechanical; Dexmedetomidine; Esketamine; Delirium
Peking University First Hospital
 2025-11
NCT07576517 NOT_YET_RECRUITING
Older Patients; Surgery; Dexmedetomidine; Esketamine; Transcranial Direct Current Stimulation; Perioperative Neurocognitive Disorders
Peking University First Hospital
 2026-06 PHASE4
NCT07103616 NOT_YET_RECRUITING
Anesthesia; Reaction; Anesthesia
Children's Hospital Los Angeles
 2025-09-01 PHASE4
NCT06128356 ACTIVE_NOT_RECRUITING
Familial Dysautonomia
NYU Langone Health
 2024-06-01 PHASE2
NCT04289142 RECRUITING
Delirium; Cognitive Dysfunction; Cognition Disorder; Neurocognitive Disorders; Mental Disorders; Confusion; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Dexmedetomidine; Hypnotics and Sedatives; Central Nervous System Depressants; Physiological Effects of Drugs; Analgesics, Non-Narcotic; Analgesics; Molecular Mechanisms of Pharmacological Action
Sunnybrook Health Sciences Centre
 2019-12-01 PHASE4
NCT07676942 NOT_YET_RECRUITING
Urethral Stricture
Centre of Postgraduate Medical Education
 2026-06
NCT04364945 ACTIVE_NOT_RECRUITING
Anesthesia and Neurotoxicity
Seoul National University Hospital
 2020-06-17
NCT07340008 RECRUITING
Orofacial Clefts; Cleft Lip and Palate; Alveolar Ridge Defect
University Medical Centre Ljubljana
 2025-09-01
NCT07705022 ENROLLING_BY_INVITATION
Healthy; Covert Consciousness
University of Michigan
 2026-08-07 PHASE2
NCT06251375 NOT_YET_RECRUITING
Respiratory Insufficiency
St. Joseph's Healthcare Hamilton
 2025-09-07 PHASE4
NCT07657715 NOT_YET_RECRUITING
Septic Shock; Sepsis; Critical Illness
First Affiliated Hospital of Wannan Medical College
 2026-08-01
NCT07570160 NOT_YET_RECRUITING
Behavior Problem
Nanjing Children's Hospital
 2026-06-01 PHASE4
NCT07610343 NOT_YET_RECRUITING
Older Adults; Cognitive Impairment; Sleep Disorders; Dexmedetomidine; Esketamine
Peking University First Hospital
 2026-06 PHASE4
NCT06192615 RECRUITING
Delirium
Massachusetts General Hospital
 2025-01-06 PHASE3
NCT07781462 NOT_YET_RECRUITING
Delirium in Intensive Care Unit; Acute Heart Failure (AHF)
Alexandria University
 2026-09 PHASE4
NCT07459322 NOT_YET_RECRUITING
OSAS (Obstructive Sleep Apneas Syndrome); DISE; Sedation
Fu Jen Catholic University Hospital
 2026-08-05
NCT06736483 RECRUITING
Anesthesia; Pediatric Surgery
University Hospital, Montpellier
 2025-02-03 PHASE2
NCT07345715 RECRUITING
Oral Melatonin; Nebulized Dexmedetomidine; Emergence Agitation; Children; Adenotonsillectomy
Tanta University
 2025-07-01
NCT07434310 NOT_YET_RECRUITING
Bowel Diseases, Inflammatory; Bowel Surgery; Laparoscopic Abdominal Surgeries
Dr. Naveed Siddiqui
 2026-07-01 PHASE3
NCT06067893 ENROLLING_BY_INVITATION
Spinal Fusion; Adolescent Idiopathic Scoliosis
Nichole Doyle
 2024-07-01 PHASE4
NCT06849466 ENROLLING_BY_INVITATION
Chronic Post-Surgical Pain
Peking Union Medical College Hospital
 2025-07-01 PHASE4
NCT07501221 NOT_YET_RECRUITING
Intrapartum Fever
Chengdu Jinjiang Maternity and Child Health Hospital
 2026-05-01
NCT07482540 NOT_YET_RECRUITING
New Onset; Atrial Fibrillation
Ain Shams University
 2026-06-01
NCT06281977 RECRUITING
Ventricular Tachycardia; Ventricular Arrhythmias; Ventricular Fibrillation; Recurrent Ventricular Tachycardia
Ottawa Heart Institute Research Corporation
 2024-05-08 PHASE3
NCT07073846 RECRUITING
Morbid Obesity Requiring Bariatric Surgery; Postoperative Pain; Postoperative Pain Management; Postoperative Analgesia; Postoperative Adjuvant Treatment; Postoperative Inflammatory Markers; Postoperative Inflammatory Response
Instituto Mexicano del Seguro Social
 2025-10-06 PHASE4
NCT07573969 RECRUITING
Perioperative Analgesia
Ain Shams University
 2026-05 PHASE3
NCT07086690 ACTIVE_NOT_RECRUITING
Inhalation Anesthesia
Ain Shams University
 2025-04-16 PHASE1
NCT04669457 ENROLLING_BY_INVITATION
Pediatric Delirium
University of Massachusetts, Worcester
 2021-04-27 PHASE4
NCT07523321 NOT_YET_RECRUITING
Spinal Surgery; Pain Intensity; Dexmedetomidine; Esketamine; Postoperative Analgesia
Peking University First Hospital
 2026-04 PHASE4
NCT06399185 RECRUITING
Urinary Catheter; Catheter-related Bladder Discomfort; Dexmedetomidine; Esketamine
Peking University First Hospital
 2024-06-06 PHASE4
NCT06824077 NOT_YET_RECRUITING
Sleep; Delirium; ICU Hospitalization
University of Alberta
 2026-08-01 EARLY_PHASE1
NCT07324057 RECRUITING
Autism Spectrum Disorder
Sun Fei
 2026-04-01
NCT07479602 RECRUITING
Adenotonsillectomy; Children; Intranasal Administration; Dexmedetomidine; Esketamine; Postoperative Pain
Peking University First Hospital
 2026-04-07 PHASE4
NCT07736352 NOT_YET_RECRUITING
Knee Osteoarthritis; Replacement, Knee; Elective Surgical Patients; ASA Class I/II Patients
China-Japan Friendship Hospital
 2026-08-01
NCT07327372 RECRUITING
Hip Osteoarthritis; Arthropathy of Hip
Poznan University of Medical Sciences
 2026-02-06
NCT07389096 RECRUITING
Opioid Free Anesthesia
Nashwa Ahmed
 2026-01-30 PHASE4
NCT05303987 RECRUITING
Obstructive Sleep Apnea
Erin Kirkham
 2022-10-05 PHASE2
NCT07386600 RECRUITING
Knee Osteoarthritis
Poznan University of Medical Sciences
 2026-01-01
NCT06875427 RECRUITING
Anterior Cruciate Ligament; Anterior Cruciate Ligament (ACL) Tear
Isabella Jaramillo
 2025-07-01 PHASE3
NCT07099222 ACTIVE_NOT_RECRUITING
Postoperative Pain; Nausea and Vomiting, Postoperative; Dizziness; Constipation; Duration of Response; Narcotics Consumption; Pain After Surgery
University of Arizona
 2024-10-10 PHASE1; PHASE2
NCT07579806 NOT_YET_RECRUITING
Postoperative Delirium (POD)
Sichuan Provincial People's Hospital
 2026-06-01 PHASE4
NCT07550881 RECRUITING
Acute Anxiety States
Tongji University
 2026-04-30 PHASE2
NCT07298525 NOT_YET_RECRUITING
Dexmedetomidine; Sedation; Safety; Preanesthetic Medication; Monitored Anaesthesia Care
Sichuan Provincial People's Hospital
 2026-01-10 PHASE4
NCT07327931 RECRUITING
Hip Osteoarthritis; Hip Pain Chronic
Poznan University of Medical Sciences
 2026-02-13
NCT07504497 NOT_YET_RECRUITING
FESS Operation
Younes Ahmed Younes
 2026-04-15 PHASE4
NCT03012971 ACTIVE_NOT_RECRUITING
Elderly; Surgery; Analgesia; Dexmedetomidine; Long-term Outcome
Peking University First Hospital
 2017-01-06
NCT07271147 RECRUITING
Postoperative Nausea and Vomiting
Affiliated Hospital of Nantong University
 2025-11-07
NCT05793060 RECRUITING
Analgesia
Damanhour Teaching Hospital
 2025-08-01 PHASE4
NCT04195256 RECRUITING
Fracture; Dislocation
Naveen Poonai
 2020-03-11 PHASE2; PHASE3
NCT06003127 RECRUITING
Anesthesia; Healthy; Consciousness, Level Altered
Massachusetts General Hospital
 2024-11-15
NCT07743853 NOT_YET_RECRUITING
Hip Osteoarthritis
Poznan University of Medical Sciences
 2026-08-01
NCT07601698 NOT_YET_RECRUITING
Emergence Agitation
Sohag University
 2026-05-01 PHASE4
NCT05361837 RECRUITING
Analgesia
National Cancer Institute, Egypt
 2022-05-10
NCT07693621 RECRUITING
Dexmedetomidine; Magnesium Sulfate; Laparoscopic Cholecystectomy
Alexandria University
 2026-05-03
NCT07214714 NOT_YET_RECRUITING
Abdominal Cancer Surgeries
Assiut University
 2025-11-01 PHASE4
NCT07626346 RECRUITING
Shoulder Pain
Kasr El Aini Hospital
 2026-06-10
NCT06859892 RECRUITING
Adults; Major Noncardiac Surgery; Dexmedetomidine; Esketamine; Postoperative Sleep Disturbances
Peking University First Hospital
 2025-03-18 PHASE4
NCT07519863 RECRUITING
Emergence Delirium in Pediatric Anesthesia
Ain Shams University
 2025-11-20 PHASE2
NCT06640738 NOT_YET_RECRUITING
Uterine Fibroids (UF)
Kaohsiung Medical University
 2024-10-01 PHASE4
NCT07184801 RECRUITING
Medical Thoracoscopy
Post Graduate Institute of Medical Education and Research, Chandigarh
 2025-10-01 PHASE3
NCT07299877 NOT_YET_RECRUITING
Brachial Plexus Blocks
Al-Azhar University
 2025-12-28 PHASE4
NCT07506044 RECRUITING
Total Dose of Bupivacaine Administered During Labor
Menoufia University
 2026-05-30
NCT07199595 NOT_YET_RECRUITING
Craniotomy Surgery
Assiut University
 2025-10-20
NCT07166666 NOT_YET_RECRUITING
Sedation; Analgesia Assessment
Oman Medical Speciality Board
 2025-09-01
NCT06164314 RECRUITING
Postoperative Delirium
Beijing Tiantan Hospital
 2024-01-25
NCT06943404 RECRUITING
Acute Stress Reaction; Acute Stress Disorder; Post-traumatic Stress Disorder
University of North Carolina, Chapel Hill
 2026-02-23 PHASE2
NCT07271459 ACTIVE_NOT_RECRUITING
Anesthesia
Ain Shams University
 2026-02-01
NCT04730609 RECRUITING
Shivering; Dose Finding Study
Mayo Clinic
 2021-09-21 PHASE4
NCT07525934 NOT_YET_RECRUITING
Postoperative Pain
Recep Karakaşoğlu
 2026-04-25
NCT07787858 COMPLETED
Postoperative Pain Intensity
Zagazig University
 2026-01-15
NCT07231926 COMPLETED
Postoperative Pain Management in Video-Assisted Thoracoscopic Surgery
Ataturk University
 2025-12-01
NCT06538584 RECRUITING
Enhanced Recovery After Surgery in a Pediatric Population
University of Chicago
 2024-09-09 PHASE1; PHASE2
NCT03480061 ACTIVE_NOT_RECRUITING
Delirium; Postoperative Cognitive Dysfunction; Dexmedetomidine; Cognitive Impairment; Depression
Sunnybrook Health Sciences Centre
 2018-08-09 PHASE4
NCT06005363 UNKNOWN
The Association of Postoperative Cognitive Dysfunction With Glymphatic Function and Neuroinflammation; The Association of Postoperative Cognitive Dysfunction With CSF Metabolomic Change
Chang Gung Memorial Hospital
 2023-07-01
NCT06993194 NOT_YET_RECRUITING
Traumatic Brain Injury; Delirium; Agitation
Benha University
 2025-06-15
NCT07596004 ACTIVE_NOT_RECRUITING
HEMODYNAMIC RESPONSETO LYRANGOSCOPY AND ENDOTRACHEAL INTUBATION
Shaheed Mohtarma Benazir Bhutto Institue of Trauma
 2026-03-10
NCT07590752 RECRUITING
Pain, Postoperative; Opioid Use; Laparotomy
Sahiwal medical college sahiwal
 2024-03-03 PHASE2; PHASE3
NCT07326332 NOT_YET_RECRUITING
Tear Film Alteration
Benha University
 2026-01-01
NCT06607861 COMPLETED
Pain Score (VAS)
Minia University
 2024-06-01 EARLY_PHASE1
NCT06979141 RECRUITING
Cough
Al-Azhar University
 2025-06-02 PHASE3
NCT06575530 RECRUITING
Effect of Drug; Adverse Drug Event; Mechanical Ventilation Complication; Critical Illness; Surgery; Sedation
Beijing Shijitan Hospital, Capital Medical University
 2025-01-20 PHASE4
NCT06865469 NOT_YET_RECRUITING
Fracture Hip Surgery
Assiut University
 2025-05-01 PHASE3
NCT03643822 TERMINATED
ACL Injury
Women's College Hospital
 2020-02-21
NCT07080229 RECRUITING
Cataract; Hypertension
Suez Canal University
 2025-07-16 PHASE3
NCT04942340 WITHDRAWN
Emergence From Anesthesia
University of Chicago
 2023-05 PHASE1
NCT06335407 RECRUITING
Alcohol Use Disorder (AUD); Post Traumatic Stress Disorder (PTSD)
Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
 2025-07-28 PHASE1
NCT07168720 RECRUITING
Preoperative Sedation
Guangzhou Novaken Pharm Co., Ltd.
 2025-08-29 PHASE2
NCT06936410 COMPLETED
Tourniquet Hypertension
Cairo University
 2025-03-01 PHASE2
NCT06993740 COMPLETED
Flap Monitoring; Inflammation; Thrombosis; Oxidative Stress; Glycocalyx; Anesthesia; Surgery; Flap Ischemia; Flap Necrosis; Flap Failure Risk Factors; Microsurgery
Dharmais National Cancer Center Hospital
 2025-06-10
NCT07350928 RECRUITING
Breast Cancer
Tianjin Medical University Cancer Institute and Hospital
 2025-03-01 PHASE3
NCT07125573 ENROLLING_BY_INVITATION
Esketamine Plus Dexmedetomidine Affect Postoperative Quality; Thoracoscopy; Lung Neoplasms
First Affiliated Hospital of Kunming Medical University
 2025-05-01
NCT07434206 ACTIVE_NOT_RECRUITING
Thyroid Neoplasms
South Egypt Cancer Institute
 2024-04-25 PHASE2; PHASE3
NCT07569614 COMPLETED
Postoperative Delirium (POD); Thoracoscopic Surgery; Dexmedetomidine; Remimazolam Besylate
First Affiliated Hospital of Kunming Medical University
 2025-04-01
NCT04824144 UNKNOWN
Hyperactive Delirium; Delirium of Mixed Origin
Bruyère Health Research Institute.
 2024-01-30 PHASE1; PHASE2
NCT07475156 COMPLETED
Post Operative Delerium
Ain Shams University
 2025-08-01 PHASE4
NCT06093893 COMPLETED
Hypotensive Anesthesia; Orthognathic Surgery
Boston Medical Center
 2025-03-04 PHASE4
NCT07392983 COMPLETED
Emergence Agitation
Muhammad Aamir Latif
 2025-07-01
NCT06837818 NOT_YET_RECRUITING
Procedural Pain
Kaohsiung Medical University Chung-Ho Memorial Hospital
 2025-03-01 PHASE4
NCT06233617 COMPLETED
Spinal Fusion; Spine Disease; Spinal Stenosis; Erector Spinae Plane Block
Poznan University of Medical Sciences
 2024-03-01 PHASE4
NCT06133712 RECRUITING
Carpal Tunnel; Dexmedetomidine; Ozone; Dexamethasone
Tanta University
 2023-11-01
NCT03596424 RECRUITING
Postoperative Pain; Opioid Use
Ciusss de L'Est de l'Île de Montréal
 2018-02-01
NCT06690021 NOT_YET_RECRUITING
Lumbar Disc Surgery
Assiut University
 2024-12-01 PHASE4
NCT06799442 NOT_YET_RECRUITING
Nephrectomy
Assiut University
 2025-03-01 PHASE2; PHASE3
NCT06067958 RECRUITING
Retinopathy of Prematurity; Dexmedetomidine
Assaf-Harofeh Medical Center
 2023-12-11 PHASE3
NCT05195034 RECRUITING
Dexmedetomidine; Delirium; Awake Craniotomy
Beijing Tiantan Hospital
 2022-03-31
NCT07054138 COMPLETED
Nebulization; Dexmedetomidine; Hemodynamic Changes; Intubation; Pneumoperitoneum; Morbid Obesity; Laparoscopic Bariatric Surgery
Tanta University
 2025-07-10
NCT06502002 COMPLETED
Surgery-Complications; Respiratory Complication; Lung Injury, Acute
Brigham and Women's Hospital
 2024-08-01
NCT06235606 COMPLETED
Acute Pain
The University of Hong Kong
 2024-05-08 PHASE3
NCT06661980 COMPLETED
Brain Injuries
Damanhour University
 2024-10-15
NCT05821972 RECRUITING
Sedation; Emergence Delirium
Assiut University
 2024-04-10 PHASE4
NCT05974527 WITHDRAWN
Agitation; Schizophrenia; Schizoaffective Disorder; Schizophreniform Disorders; Bipolar Disorder
Brigham and Women's Hospital
 2023-09-01 PHASE4
NCT06417125 COMPLETED
Behavior Problem
Fujian Provincial Hospital
 2024-05-22 PHASE4
NCT06354673 COMPLETED
Paroxysmal Sympathetic Hyperactivity
Zagazig University
 2024-04-04
NCT06614010 RECRUITING
Dexmedetomidine; Fascia Iliaca Block
Qianfoshan Hospital
 2023-02-05 PHASE1
NCT06030804 RECRUITING
Elderly; Cancer Surgery; Dexmedetomidine; Long-Term Survivors
Peking University First Hospital
 2023-09-12
NCT06778811 RECRUITING
Sleep Wake Disorders; Esketamine and the Quality of Recovery; Dexmedetomidine
Nanjing First Hospital, Nanjing Medical University
 2024-10-11 PHASE4
NCT07023991 ENROLLING_BY_INVITATION
Post-operative Pain
Ain Shams University
 2025-05-01 PHASE1
NCT06958718 COMPLETED
Post Operative Pain
Fayoum University Hospital
 2025-05-06 PHASE4
NCT06853067 COMPLETED
Temperature Change, Body
SMG-SNU Boramae Medical Center
 2025-04-15
NCT06974656 COMPLETED
Infusion; Dexmedetomidine; Lidocaine; Acute; Postoperative Pain; Modified Radical Mastectomy
Cairo University
 2025-05-15
NCT07022821 RECRUITING
Postoperative Pain; Cesarean Section Pain
Fatima Memorial Hospital
 2025-05-16 PHASE4
NCT06769737 NOT_YET_RECRUITING
Spinal Anesthesia Evaluation
King Abdulaziz Medical City
 2025-03-01 PHASE4
NCT06740903 RECRUITING
Hemodynamics Instability; Post Operative Pain; Gastrointestinal Dysfunction; Cholecystitis
Sahiwal medical college sahiwal
 2024-08-06 PHASE2; PHASE3
NCT07244822 COMPLETED
Traumatic Brain Injury; Cerebral Oxygen Saturation; NIR Spectroscopy
Universitas Jenderal Soedirman
 2025-06-01
NCT06233565 COMPLETED
Foot Injuries and Disorders; Ankle Injuries and Disorders
Poznan University of Medical Sciences
 2024-02-09 PHASE4
NCT06252662 RECRUITING
Breast Cancer
United States Naval Medical Center, Portsmouth
 2024-10-15 PHASE4
NCT05264077 UNKNOWN
Agitation, Emergence
Sheikh Zayed Medical College
 2024-11-01 EARLY_PHASE1
NCT06756594 COMPLETED
Propofol
Sohag University
 2024-11-12
NCT07149168 COMPLETED
Pain During Spinal Positioning
Ain Shams University
 2024-12-10 PHASE1
NCT06970678 RECRUITING
Laparoscopic Sleeve Gastrectomy (LSG)
Alexandria University
 2025-04-04 PHASE1; PHASE2
NCT04204798 ACTIVE_NOT_RECRUITING
Elderly; Surgery; Intensive Care Unit; Dexmedetomidine; Overall Survival
Peking University First Hospital
 2020-08-28
NCT04946396 COMPLETED
Laparoscopic Surgery
National Institute of Cardiology, Laranjeiras, Brazil
 2022-04-01
NCT05705128 ENROLLING_BY_INVITATION
Pain Management
New Valley University
 2023-08-01 PHASE2; PHASE3
NCT05934669 RECRUITING
Laceration of Skin; Anxiety; Discharge Time
University of Oklahoma
 2023-11-14 PHASE4
NCT06808295 RECRUITING
Patients Undergoing External Dacrocystorhinostomy Operations; Assess Decreased Anesthetic Requirements Intraoperative
Research Institute of Ophthalmology, Egypt
 2024-04-16 PHASE1
NCT06305221 UNKNOWN
Opioid-Free Anesthesia; Laparoscopic Sleeve Gastrectomy; Postoperative Vomiting; Postoperative Recovery
Beijing Friendship Hospital
 2024-03-09
NCT06233604 UNKNOWN
Hip Osteoarthritis; Hip Arthropathy; Hip Pain Chronic
Poznan University of Medical Sciences
 2024-04-10 PHASE4
NCT06363578 COMPLETED
Dexmedetomidine; External Oblique Intercostal Plane Block; Splenectomy
Tanta University
 2024-04-20
NCT06366412 UNKNOWN
Cognitive Impairment
Minia University Hospital
 2024-04 PHASE4
NCT06386770 UNKNOWN
Erector Spinae Block; Dexmedetomidine
Aswan University
 2024-06-01 PHASE3
NCT05849597 RECRUITING
Intensive Care Unit Delirium
University of Novi Sad
 2022-03-01 PHASE3
NCT05708989 WITHDRAWN
Hypospadias; Penile Torsion; Chordee; Phimosis
University Hospitals Cleveland Medical Center
 2023-03-06 PHASE4
NCT04700514 UNKNOWN
Retinoblastoma
Seoul National University Hospital
 2021-02-05
NCT04772222 COMPLETED
Hypoxic-Ischemic Encephalopathy; Pain
University of Utah
 2022-06-20 PHASE2
NCT06264739 UNKNOWN
Postoperative Acute Pain; Opioid Consumption
Aydin Adnan Menderes University
 2024-01-01
NCT05788393 COMPLETED
Analgesia
Assiut University
 2024-04-01 PHASE4
NCT05775861 UNKNOWN
Anesthesia; Shoulder Pain; Post Operative Pain
Ciusss de L'Est de l'Île de Montréal
 2022-08-23
NCT06641206 RECRUITING
Chronic Knee Pain
Tanta University
 2024-09-17
NCT06636578 RECRUITING
Analgesia
Fayoum University
 2024-10-10 PHASE4
NCT04871308 COMPLETED
Cardiac Surgery; Cardiopulmonary Bypass
Seoul National University Hospital
 2021-07-07
NCT06662318 COMPLETED
Pain, Postoperative
Benha University
 2024-10-01
NCT06575179 RECRUITING
Laparoscopic Cholecystectomy
Fujian Provincial Hospital
 2024-09-02 PHASE4
NCT06207344 UNKNOWN
Anesthesia Recovery Period; Postoperative Complications
The Second Affiliated Hospital of Chongqing Medical University
 2023-10-21
NCT05466708 UNKNOWN
Dexmedetomidine; Ketamine; Analgesia; Intensive Care Units; Mechanical Ventilation
The First Affiliated Hospital with Nanjing Medical University
 2022-08-11 PHASE4
NCT05511415 COMPLETED
Postpartum Hemorrhage
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
 2022-11-02
NCT07241351 COMPLETED
Analgesia; Sedation and Analgesia; Neonatal; Mechanical Ventilation in Neonates
Ain Shams University
 2024-03-01 PHASE2; PHASE3
NCT06834841 UNKNOWN
Post Spinal Shivering
Ain Shams University
 2024-04-01
NCT06830564 COMPLETED
Emergence Delirium
Ain Shams University
 2024-05-01 PHASE2; PHASE3
NCT06835010 COMPLETED
AKI - Acute Kidney Injury
Tanta University
 2024-05-20
NCT05829148 UNKNOWN
Endoscopic Sinus Surgery
Egymedicalpedia
 2023-05-01 EARLY_PHASE1
NCT06331182 COMPLETED
Dexmedetomidine; Ketamine; External Oblique Intercostal Plane Block; Post Thoracotomy Pain
Tanta University
 2024-03-26
NCT06076668 UNKNOWN
Dexmedetomidine; Melatonin; Delirium
Tanta University
 2023-10-16
NCT06614881 COMPLETED
Post Operative Delirium
Tanta University
 2024-07-01
NCT06785285 COMPLETED
Cesarean Section
Sohag University
 2024-03-01
NCT06414395 UNKNOWN
GIT Endoscopy; Procedural Sedation
Theodor Bilharz Research Institute
 2024-05-01 PHASE4
NCT06490614 UNKNOWN
Anterior Cervical Discectomy and Fusion (ACDF)
Kasr El Aini Hospital
 2024-07 PHASE4
NCT05591417 COMPLETED
Analgesia
National Cancer Institute, Egypt
 2022-10-27
NCT06655025 COMPLETED
Cardiac Surgery; Postoperative Cognitive Dysfunction; Neurologic Manifestations
Sohag University
 2023-10-08
NCT06482229 COMPLETED
Regional Anesthesia Morbidity
Sivas State Hospital
 2024-07-01
NCT04082767 UNKNOWN
Mechanically Ventilated, Critically Ill Children
Douglas Fraser
 2021-06-08 PHASE3
NCT06318546 COMPLETED
Post Spinal Shivering
Ain Shams University
 2024-04-01 PHASE1
NCT06720220 COMPLETED
Airway Complication of Anesthesia
Zagazig University
 2023-06-01 PHASE3
NCT06502262 COMPLETED
Post Operative Pain
Ain Shams University
 2024-01-15 PHASE1
NCT06514040 COMPLETED
Post-Dural Puncture Headache
Fayoum University Hospital
 2023-11-27
NCT06423859 UNKNOWN
Post Operative Pain, Acute
Benha University
 2024-02-01
NCT04981951 UNKNOWN
Supraclavicular Brachial Plexus Block
Zaher Nazzal
 2020-10-01
NCT06551259 COMPLETED
Randomized Controlled Trial; Dexmedetomidine
Chinese PLA General Hospital
 2024-01-01 PHASE4
NCT04144933 UNKNOWN
Anesthesia; General Anesthesia; Analgesics, Opioid; Opioid Free Anesthesia; Postoperative Ileus; Colorectal Surgery; Laparoscopic Surgery; Analgesia; Dexmedetomidine; Lidocaine; Ketamine
University of Saskatchewan
 2021-05-15 PHASE3
NCT06229054 COMPLETED
Dexmedetomidine
Cairo University
 2024-02-01 EARLY_PHASE1
NCT07058493 COMPLETED
Knee Surgeries
Cairo University
 2024-01-02
NCT04454515 UNKNOWN
Morphine Consumption
National Taiwan University Hospital
 2021-04-20
NCT06737458 COMPLETED
Serratus Anterior Plane Block; Erector Spinae Plane Block; Dexmedetomidine; Bupivacaine; Ultrasound; Pain Management; Mastectomy
Kafrelsheikh University
 2023-07-01
NCT06386783 UNKNOWN
Dexmedetomidine; Fentanyl
Aswan University
 2023-07-01 PHASE3
NCT06207331 TERMINATED
Respiratory Function Tests; Chronic Obstructive Pulmonary Disease; Dexmedetomidine
The Second Affiliated Hospital of Chongqing Medical University
 2023-10-28
NCT05951387 COMPLETED
Haemodynamic Instability
Benha University
 2023-06-01 PHASE4
NCT04873596 UNKNOWN
Procedural Sedation
Zagazig University
 2021-05-15 PHASE2
NCT05610774 COMPLETED
Preeclampsia Severe; Optic Nerve Sheath Diameter
Benha University
 2023-06-06
NCT06098209 COMPLETED
Dexmedetomidine; Propofol; Mechanical Ventilation; Salivary Alpha Amylase; Stress
Tanta University
 2023-10-24
NCT06389318 COMPLETED
Inguinal Hernia Repair
Benha University
 2023-03-26
NCT06020781 COMPLETED
Dexmedetomidine; Bupivacaine; Supraclavicular Brachial Plexus Block
Kafrelsheikh University
 2023-10-09
NCT06382961 COMPLETED
Delirium in Old Age; Anesthesia; Adverse Effect
Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd.
 2023-11-11
NCT06046105 UNKNOWN
Postoperative Pain, Acute
Ain Shams University
 2023-09-15 PHASE2; PHASE3
NCT06371638 COMPLETED
Postoperative Cognitive Dysfunction; Postoperative Pain
Udayana University
 2024-01-07 PHASE4
NCT05689242 UNKNOWN
Colonoscopy
Assiut University
 2023-03 PHASE4
NCT06489574 COMPLETED
Post-operative Pain; Thoracic Epidural; Thoracotomy Surgery
Cairo University
 2023-01-01
NCT06470854 COMPLETED
Post-Dural Puncture Headache
Tanta University
 2023-11-01
NCT07385898 COMPLETED
Rectal Tumors; Tumor of Sigmoid Colon; Lung Injury; Surgery, Laparoscopic; Dexmedetomidine
The Second Affiliated Hospital of Chongqing Medical University
 2023-04-17
NCT04876937 TERMINATED
Adult; Intensive Care Unit; Sepsis; Mechanical Ventilation; Delirium; Dexmedetomidine
Peking University First Hospital
 2021-05-28
NCT06014359 UNKNOWN
Dexmedetomidine; Hemodynamics; Laparoscopic Bariatric Surgery
Tanta University
 2023-08-27
NCT05243940 UNKNOWN
Pain, Post Operative; Pain, Acute; Pain, Chronic; Pain, Neuropathic; Pain, Nociceptive; Ketamine; Dexmedetomidine; Lidocaine; Fentanyl; Analgesia; Analgesics; Analgesics Non-narcotic
Aretaieion University Hospital
 2022-03-07
NCT06292273 COMPLETED
Post Operative Pain
Menoufia University
 2023-10-10
NCT05347173 COMPLETED
Analgesia
Mansoura University
 2022-06-21
NCT05743725 UNKNOWN
Brain Tumor
Assiut University
 2023-03-15
NCT06409104 COMPLETED
Sedation in ERCP
National Cancer Institute, Egypt
 2023-09-01
NCT06527976 COMPLETED
Postoperative Pain
Assiut University
 2022-02-15
NCT05875077 UNKNOWN
Nausea and Vomiting, Postoperative
Cairo University
 2022-05-01
NCT05661227 UNKNOWN
Ischemic Reperfusion Injury
Hebei Medical University Third Hospital
 2023-01-01
NCT04356638 UNKNOWN
Anxiety State; Perioperative/Postoperative Complications
King Faisal Specialist Hospital & Research Center
 2021-10-17 PHASE3
NCT05828199 UNKNOWN
Nasal Polyps; Nasal Septum, Irregular; Functional Endoscopic Sinus Surgery
Al-Azhar University
 2022-12-01 PHASE1
NCT05850455 COMPLETED
Lumbar Disc Herniation
Ain Shams University
 2023-05-20
NCT05351489 COMPLETED
Transurethral Resection of Prostate
Mansoura University
 2022-05-30 EARLY_PHASE1
NCT05937282 UNKNOWN
Hemodynamic Responses; Laparoscopic Cholecystectomy; Dexmedetomidine; Lidocaine; Propofol
Menoufia University
 2023-07-01 PHASE4
NCT05325762 UNKNOWN
Sleep Disorder
Xiangya Hospital of Central South University
 2022-12-01 PHASE4
NCT04266665 COMPLETED
Brain Tumor; Metabolic Disturbance; Inflammatory Response; Oxygen Deficiency
Georgia Tsaousi
 2020-03-12 PHASE4
NCT05692167 UNKNOWN
Dexmedetomidine; Cataract Surgery; Peribulbar; Anesthesia
Kafrelsheikh University
 2023-07-15 PHASE2
NCT06909305 COMPLETED
Intraarticular; Ozone; Prolotherapy; Dexmedetomidine; Pain; Knee Osteoarthritis
Tanta University
 2022-10-01
NCT05595083 UNKNOWN
Functional Endoscopic Sinus Surgery; Dexmedetomidine
Kafrelsheikh University
 2022-11-01
NCT04105946 UNKNOWN
Functional Endoscopic Sinus Surgery
University of Thessaly
 2022-10
NCT05700045 COMPLETED
Multimodal Analgesia; Cesarean Section
Xijing Hospital
 2023-05-31
NCT05159674 UNKNOWN
Acupuncture; Dexmedetomidine; Anesthesia
Shanghai Yueyang Integrated Medicine Hospital
 2021-12-15
NCT05998551 UNKNOWN
Effectiveness of Single Shot Intra-thecal Analgesia in Multiparous Women Scheduled for Normal Vaginal Delivery
Ain Shams University
 2023-01-01
NCT05615194 UNKNOWN
Inhalation Anesthesia; Dexmedetomidine; Sevoflurane; Laparoscopy
Ciusss de L'Est de l'Île de Montréal
 2022-12-05
NCT03809442 COMPLETED
Postoperative Analgesia
Aga Khan University
 2019-06-25 PHASE4
NCT05487196 COMPLETED
Pregnancy Related
Grace Lim, MD, MS
 2022-09-28 PHASE2
NCT03984240 COMPLETED
Brain Glioma; Midazolam; Dexmedetomidine
Beijing Tiantan Hospital
 2020-11-25
NCT05767827 COMPLETED
Local Anesthesia Adjuvants; Upper Extremity Fracture; Brachial Plexus Block
Nepal Medical College and Teaching Hospital
 2023-02-01
NCT05500261 UNKNOWN
Dental Anxiety
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
 2022-11-01
NCT05757063 COMPLETED
Propofol; Dexmedetomidine; Electrophysiological Balance Index; QT Interval, Variation in; Tp-e Interval; QT Dispersion; Knee Osteoarthritis
Ankara City Hospital Bilkent
 2023-03-01
NCT05194904 UNKNOWN
Postoperative Pain
Assiut University
 2022-01 PHASE2; PHASE3
NCT05003102 WITHDRAWN
Critical Illness; Sedation Complication; Delirium
Vanderbilt University Medical Center
 2023-02-20 PHASE4
NCT05089526 UNKNOWN
Pain, Postoperative; Pain, Acute; Pain, Chronic; Cholecystectomy; Ketamine; Dexmedetomidine; Lidocaine; Central Nervous System Depressants; Analgesia; Analgesics; Analgesic Non-narcotic
Aretaieion University Hospital
 2021-10-11
NCT05674877 COMPLETED
Liver Cirrhosis
Cairo University
 2022-12-01 PHASE3
NCT05674253 UNKNOWN
Atrial Fibrillation New Onset
Ain Shams University
 2022-12-25 EARLY_PHASE1
NCT05134363 COMPLETED
Postoperative Nausea and Vomiting; Head and Neck Surgeries
Cairo University
 2021-08-11
NCT05370963 COMPLETED
Pain, Chronic
Minia University
 2022-05-20 EARLY_PHASE1
NCT03708315 COMPLETED
Schizophrenia; Schizoaffective Disorder
Yale University
 2020-03-09 PHASE1
NCT06186895 COMPLETED
Pain, Postoperative
Helwan University
 2021-07-20
NCT06052111 COMPLETED
Dexmedetomidine; Fentanyl; Time to Extubation; Morbid Obesity; Laparoscopic Sleeve Gastrectomy
Helwan University
 2021-05-15
NCT05341154 COMPLETED
Emergence Delirium
Huda Fahmy Mahmoud, PhD
 2021-12-01
NCT04827056 COMPLETED
Alcohol Use Disorder (AUD); Post Traumatic Stress Disorder (PTSD)
Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
 2021-11-09 PHASE1
NCT05813106 UNKNOWN
Emergence Delirium; Dexmeditomidine
Security Forces Hospital
 2022-12-01 PHASE4
NCT05626998 COMPLETED
Anesthesia
Ain Shams University
 2022-11-01 PHASE4
NCT05664542 UNKNOWN
Postoperative Pain
Security Forces Hospital
 2022-12-15 PHASE4
NCT05579964 COMPLETED
Congenital Heart Disease in Children; Cardiopulmonary Bypass; Tetralogy of Fallot
National Cardiovascular Center Harapan Kita Hospital Indonesia
 2022-10-10 PHASE2; PHASE3
NCT05634148 COMPLETED
Postoperative Delirium
Security Forces Hospital
 2022-12-22 PHASE3
NCT05698758 UNKNOWN
Cataract; Preoperative Sedation
Guangzhou First People's Hospital
 2023-01-10
NCT05622656 UNKNOWN
Pain, Postoperative
First People's Hospital of Chenzhou
 2022-12-01 PHASE4
NCT05950555 COMPLETED
Malondialdehyde; Heme Oxygenase; C-Reactive Protein
Ataturk University
 2021-12-30
NCT05552391 COMPLETED
Post Operative Pain
Kasr El Aini Hospital
 2022-09-01 PHASE4
NCT05905757 COMPLETED
Transversus Abdominis Plane Block
Yuzuncu Yil University
 2022-03-01
NCT05283083 COMPLETED
Septic Shock; Sepsis
Mansoura University
 2022-03-25 PHASE2
NCT06531603 COMPLETED
Post Operative Pain; Bradycardia; Hypotension; Nausea; Vomiting
Sahiwal medical college sahiwal
 2022-02-20 PHASE2; PHASE3
NCT05481281 UNKNOWN
Chills
Hamdard University
 2022-08-01 PHASE3
NCT05342844 COMPLETED
Analgesia
Mansoura University
 2022-05-01
NCT05337085 UNKNOWN
Inguinal Hernia
Sheikh Zayed Medical College
 2022-06-30 PHASE1
NCT05013320 WITHDRAWN
Bladder Irritable
Kangbuk Samsung Hospital
 2021-09-01
NCT05857410 COMPLETED
Spine Surgery; Postoperative Delirium and Chills
Jincheng General Hospital
 2019-01-01
NCT05439564 COMPLETED
Intrathecal Morphine; Intrathecal Morphine-dexmedetomidine Combination; Postoperative Pain Control; Total Knee Replacement
Tanta University
 2022-07-01
NCT05631028 COMPLETED
Lung Cancer; Anesthesia Induction
Shiyou Wei
 2022-12-01
NCT05216055 WITHDRAWN
Colorectal Disorders; Surgery
University of Colorado, Denver
 2022-04-19 PHASE2
NCT05963958 COMPLETED
COVID-19; Delirium; Critical Illness
Suellen Andrade
 2021-04-14
NCT05369468 COMPLETED
Dexmedtomidine in Erector Spinae Block for Laparscopic Cholecystectomy
Tanta University
 2020-01-22 PHASE1; PHASE2
NCT04391855 COMPLETED
Analgesia; Pain, Postoperative; Spinal Stenosis; Spinal Disease
Aristotle University Of Thessaloniki
 2020-05-10 PHASE4
NCT05361642 UNKNOWN
Drug Use
Ain Shams University
 2022-02-03
NCT05447507 COMPLETED
Orthopedic Disorder
Seoul National University Hospital
 2022-07-08 PHASE4
NCT04413864 UNKNOWN
SARS-CoV 2
Assistance Publique - Hôpitaux de Paris
 2020-04-24
NCT05079672 UNKNOWN
Cardiopathy; Coronary Artery Disease; Valve Heart Disease; Pain
University of Sao Paulo
 2021-10-07 PHASE4
NCT04260659 COMPLETED
Obesity; Postoperative Pain; Postoperative Nausea; Postoperative Vomiting; Opioid Use
Medical University of Warsaw
 2020-02-04 PHASE4
NCT04385602 COMPLETED
Intratracheal; Dexmedetomidine
Assiut University
 2020-06-01 PHASE2; PHASE3
NCT05636566 COMPLETED
Invasive Cancer; Pediatric Cancer
Alexandria University
 2022-02-15 PHASE2; PHASE3
NCT04665453 COMPLETED
Electroencephalography; Child; Dexmedetomidine; Melatonin; Sleep; Epilepsy
University Medical Centre Ljubljana
 2020-09-01
NCT04608331 COMPLETED
Obstructive Sleep Apnea; Analgesia; Dexmedetomidine; High-flow Nasal Cannula; Sleep Quality
Peking University First Hospital
 2021-01-29 PHASE4
NCT05489900 UNKNOWN
Physiological Effects of Drugs
Universidade Federal do Rio de Janeiro
 2022-04-01 PHASE3
NCT05175781 COMPLETED
Chest Trauma
Aswan University Hospital
 2022-01-18
NCT05291221 COMPLETED
Postoperative Complications
Minia University
 2021-02-22
NCT04266145 COMPLETED
Post Spinal Anesthesia Shivering
Mansoura University
 2020-02-29
NCT05342376 UNKNOWN
Postoperative Shivering; Cesarean Delivery
Rehman Medical Institute - RMI
 2022-02-01 PHASE4
NCT03892928 COMPLETED
Colonoscopy
West China Hospital
 2019-12-01
NCT04529135 COMPLETED
Gastric Cancer
Gangnam Severance Hospital
 2020-08-26
NCT04206059 COMPLETED
Sleep; Sedation Complication
Washington University School of Medicine
 2021-01-20
NCT05273671 UNKNOWN
Agitation
Alexandria University
 2022-03-01 PHASE4
NCT05171985 UNKNOWN
COVID-19 Pneumonia; Atrial Fibrillation
Tanta University
 2022-01
NCT04906889 WITHDRAWN
Gynecologic Disease
The Catholic University of Korea
 2021-06-01
NCT04838379 COMPLETED
Cholecystitis; Appendicitis
Assiut University
 2021-04-01
NCT05111431 COMPLETED
Preoperative Sedation of Children
Shanghai Hengrui Pharmaceutical Co., Ltd.
 2021-11-24 PHASE3
NCT05300802 COMPLETED
Congenital Heart Disease in Children; Cardiopulmonary Bypass
National Cardiovascular Center Harapan Kita Hospital Indonesia
 2021-12-16 PHASE2; PHASE3
NCT03289325 COMPLETED
Cardiac Surgery; Dexmedetomidine; Long-term Outcome; Mortality; Quality of Life
Peking University First Hospital
 2021-10-21
NCT03938831 UNKNOWN
Delirium, Dexmedetomidine, Postoperative PCA
Korea University Guro Hospital
 2019-05-01
NCT06735443 COMPLETED
Hemodynamic Stability; Post Operative Pain; Inguinal Hernia Repair
Sahiwal medical college sahiwal
 2021-03-06 PHASE2; PHASE3
NCT05158348 UNKNOWN
Dexmedetomidine; Lidocaine; Tonsillectomy
Kasr El Aini Hospital
 2021-11-05 PHASE3
NCT03355053 COMPLETED
Delirium; Sleep
Massachusetts General Hospital
 2018-05-29 PHASE2
NCT04919174 UNKNOWN
Bronchoscopy; Sedation
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2021-04-23 PHASE4
NCT04969705 COMPLETED
Pain Management in Adult Females in Child Bearing Period Aging From 20 to 45 Years Who Are Scheduled for Elective Cesarean Section
Sohag University
 2022-01-01
NCT04270708 UNKNOWN
Autistic Disorder
Rabin Medical Center
 2020-03-01 PHASE4
NCT03325972 COMPLETED
Chronic Pain
NYU Langone Health
 2016-09-14 PHASE4
NCT05993975 COMPLETED
Post Operative Pain
Sindh Institute of Urology and Transplantation
 2021-07-20 PHASE4
NCT06354478 COMPLETED
Breast Cancer; Pain, Postoperative; Pain, Acute
National Cancer Institute, Egypt
 2021-01-01
NCT05342376 Unknown status
Postoperative Shivering|Cesarean Delivery
Rehman Medical Institute - RMI
 2022-02-01 Phase 4
NCT04508166 COMPLETED
Intrusive Thought; Psychological Trauma; Inflammatory Response; Physiological Stress
Psychiatric University Hospital, Zurich
 2021-10-01
NCT04817033 COMPLETED
Anesthesia; Anesthesia Complication; Osa Syndrome; Transurethral Resection of Prostate; Sedation Complication; Intraoperative Complications; Snoring; Airway Obstruction
University Hospital of Split
 2021-04-01 PHASE4
NCT04791475 COMPLETED
Brachial Plexus Block; Dexmedetomidine; Dexamethasone; Bupivacaine
Tribhuvan University Teaching Hospital, Institute Of Medicine.
 2021-02-22
NCT04042727 TERMINATED
Rapid Atrial Fibrillation; Heart Rate Control
Stony Brook University
 2019-08-21 PHASE2; PHASE3
NCT05065775 COMPLETED
Pharmacokinetics; Arthritis Knee; Arthritis of Hip; Anesthesia
Turku University Hospital
 2021-11-01 PHASE4
NCT04576975 UNKNOWN
Morbid Obesity; Surgery
Ain Shams University
 2021-04-20 PHASE3
NCT04282239 WITHDRAWN
Pain, Postoperative; Cardiac Surgery
NYU Langone Health
 2021-03-01
NCT04149626 UNKNOWN
Hallux Valgus and Bunion; Sedation
Asklepieion Voulas General Hospital
 2020-01-29 PHASE2
NCT04642651 COMPLETED
Elderly; Total Knee Arthroplasty; Femoral Nerve Block; Dexmedetomidine; Functional Outcome
Peking University First Hospital
 2020-11-25 PHASE4
NCT03530371 COMPLETED
Auditory Brainstem Response
Fondation Lenval
 2019-05-02 PHASE3
NCT04266340 COMPLETED
Agitation
Eye & ENT Hospital of Fudan University
 2020-12-13
NCT05919173 COMPLETED
Post Operative Pain
Sindh Institute of Urology and Transplantation
 2021-07-10 PHASE4
NCT06169475 COMPLETED
Septic Shock; Stress Response; Cerebral Hemodynamics
Xinchen Wang
 2020-11-01
NCT03601091 UNKNOWN
Effect of Sedation on Heart Rate Variability
Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
 2018-03-22
NCT04926454 UNKNOWN
Pain, Postoperative
Ain Shams University
 2020-09-22 PHASE1; PHASE2
NCT03251651 COMPLETED
Lower Extremity Problem; Delirium; Propofol; Dexmedetomidine
Seoul National University Bundang Hospital
 2017-06-15
NCT03417999 TERMINATED
Dexmedetomidine; Congenital Heart Disease
Children's Hospital of Philadelphia
 2018-06-14 PHASE1
NCT04535089 COMPLETED
Analgesia
Zagazig University
 2020-10-01 PHASE1; PHASE2
NCT04920669 COMPLETED
Postoperative Pain
Mohamed Elsayed Hassan
 2021-07-01
NCT03109990 COMPLETED
Breast Cancer
RenJi Hospital
 2016-05
NCT04409964 COMPLETED
Gynecologic Disease
The Catholic University of Korea
 2020-06-01
NCT04621110 UNKNOWN
Pediatric Cancer; Analgesia; Procedural Pain
University of Sao Paulo General Hospital
 2021-06-01 PHASE3
NCT04917029 COMPLETED
Anesthesia
Ain Shams University
 2021-05-18
NCT04399343 UNKNOWN
Central Nervous System Diseases
Capital Medical University
 2021-03-01 PHASE4
NCT04652427 UNKNOWN
Sedation Complication
Peking University People's Hospital
 2020-08-20
NCT04018703 UNKNOWN
Balanced Anesthesia; Adjuvants,Anesthesia
Eye & ENT Hospital of Fudan University
 2019-11-01
NCT03624595 COMPLETED
Cardiac Surgery; Cardiopulmonary Bypass; Dexmedetomidine; Delirium; Survival
Dong-Xin Wang
 2019-04-16
NCT03747432 COMPLETED
Transcatheter Aortic Valve Replacement; Procedural Sedation
University Medical Centre Ljubljana
 2019-01-15 PHASE4
NCT05979558 COMPLETED
Ropivacaine; Infraumbilical Surgery; Dexmedetomidine; Analgesia
National Academy of Medical Sciences, Nepal
 2020-06-16
NCT03151863 TERMINATED
Analgesia; Sedation; Anxiolysis
Walid HABRE
 2018-11-14 PHASE3
NCT04836819 COMPLETED
Morbid Obesity; Bariatric Surgery Candidate; Pain; Postoperative
Ondokuz Mayıs University
 2021-04-08
NCT04383418 UNKNOWN
Preoperative Sedation
Jiangsu HengRui Medicine Co., Ltd.
 2020-05-31 PHASE2; PHASE3
NCT04700228 UNKNOWN
Pain, Postoperative
Dr. Ruth K.M. Pfau Civil Hospital, Karachi
 2021-02 PHASE4
NCT03317067 COMPLETED
Delirium; Agitation
University Hospital, Clermont-Ferrand
 2017-12-21 PHASE3
NCT04411329 COMPLETED
Caudal Analgesia for Lumosacral Spine Surgeries
Ain Shams University
 2020-06-06
NCT04111926 COMPLETED
Overall Survival
Peking University First Hospital
 2019-10-07 PHASE4
NCT04680650 UNKNOWN
Thyroid Nodule
Affiliated Cancer Hospital & Institute of Guangzhou Medical University
 2020-04-30
NCT06037135 COMPLETED
Pheochromocytoma
Yonsei University
 2012-12-03
NCT04668456 UNKNOWN
Acute Postoperative Pain
Menoufia University
 2020-08-15 PHASE3
NCT04073758 UNKNOWN
Chest Wall Disorder
Jung Min Koo
 2019-09-02
NCT04470050 COMPLETED
Opioid Withdrawal
BioXcel Therapeutics Inc
 2020-06-09 PHASE1; PHASE2
NCT04704622 COMPLETED
Cannula Site Pain
Ain Shams University
 2021-01-01 PHASE2; PHASE3
NCT04577430 COMPLETED
Dexmedetomidine; General Anesthesia; Cardiac Electrophysiology; Cardiac Function
Yangzhou University
 2019-09-08
NCT04607525 COMPLETED
Hemodynamic Instability; Supratentorial Neoplasms
Ain Shams University
 2020-11-21 PHASE4
NCT04971759 COMPLETED
Dexmedetomidine; Fentanyl
Assiut University
 2019-12-01 PHASE2; PHASE3
NCT03355534 COMPLETED
Aneurysm Cerebral
Zhihong LU
 2018-01-05
NCT04508894 COMPLETED
Supraclavicular Brachial Plexus Block
Minia University
 2019-04-21
NCT04464616 COMPLETED
Postoperative Pain
Tanta University
 2020-07-15
NCT04494828 COMPLETED
Central Nervous System Diseases
Capital Medical University
 2020-08-10 PHASE4
NCT03933280 COMPLETED
Conscious Sedation
Menoufia University
 2019-07-01 PHASE2
NCT04113720 COMPLETED
Post-tonsillectomy Analgesia; Levobupivacaine
Assiut University
 2019-11-15 PHASE1; PHASE2
NCT03933306 COMPLETED
Blood Pressure; Dexmedetomidine; High-risk Patients; Abdominal Surgery; Postoperative Complications
Peking University First Hospital
 2019-05-20 PHASE4
NCT03938857 TERMINATED
Dexmedetomidine; Mechanical Ventilation Complication; Critically Ill
Duke University
 2019-07-18 PHASE1
NCT04662177 COMPLETED
Carotid Stenosis
Insel Gruppe AG, University Hospital Bern
 2018-11-21 PHASE4
NCT02053766 TERMINATED
Mitochondrial Diseases
The University of Texas Health Science Center, Houston
 2014-01-10
NCT02923128 COMPLETED
Postoperative Cognitive Dysfunction; Postoperative Delirium
Zhejiang Cancer Hospital
 2016-11 PHASE4
NCT02698930 UNKNOWN
Infective Endocarditis
Yonsei University
 2016-08
NCT04135014 UNKNOWN
Anxiety
Second Affiliated Hospital of Wenzhou Medical University
 2019-10-25 PHASE4
NCT04111328 COMPLETED
Analgesia, Patient-Controlled
Jun Wang
 2019-10-08 PHASE4
NCT04771637 COMPLETED
Dexmedetomidine; Perioperative; Electrolyte
Yangzhou University
 2017-01-01
NCT04200235 COMPLETED
Preoperative Sedation
Jiangsu HengRui Medicine Co., Ltd.
 2020-01-06 PHASE1
NCT03622047 UNKNOWN
Pharmacological Action
Fudan University
 2018-08-15
NCT04285255 COMPLETED
Narcotics; Recovery Quality; Analgesia; Bariatric Surgery
Al Mashfa Medical Center
 2020-03-01
NCT03399474 COMPLETED
Limb Deformity
Assiut University
 2018-03-01 PHASE4
NCT04048200 COMPLETED
Adverse Effect of Drugs and Medicaments in Therapeutic Use; Adverse Effects in the Therapeutic Use of Anaesthetics
Tanta University
 2019-09-01 PHASE4
NCT04314050 COMPLETED
Catheter Related Complication
Ankara Diskapi Training and Research Hospital
 2020-03-10
NCT06185127 COMPLETED
Lung Diseases; Diagnosis; Anesthesia
University of Patras
 2019-09-01 PHASE3
NCT03466632 UNKNOWN
Colonic Diseases
Tanta University
 2016-04-01 PHASE3
NCT02409810 COMPLETED
Anxiety; Burns
Ohio State University
 2015-04 PHASE1; PHASE2
NCT03284307 COMPLETED
Unconsciousness; Consciousness
University of Wisconsin, Madison
 2017-08-10 PHASE4
NCT03204006 COMPLETED
Stress Response During Laryngoscopy Intubation
Assiut University
 2018-03-08
NCT04307290 COMPLETED
Arthropathy of Knee; Spinal Anesthesia; Tourniquet; Ischemia-reperfusion Injury
Wonkwang University Hospital
 2020-02-03 PHASE4
NCT04968392 COMPLETED
Adductor Canal Block; Levobupivacaine; Dexmedetomidine
Assiut University
 2019-03-01 PHASE2; PHASE3
NCT03466242 WITHDRAWN
Conscious Sedation; Distal Radius Fracture
Phoenix Children's Hospital
 2017-01-01 EARLY_PHASE1
NCT03762785 UNKNOWN
Abdominal Cancer
Assiut University
 2018-12-10 PHASE1; PHASE2
NCT03524950 UNKNOWN
Hysteromyoma
Beijing Anzhen Hospital
 2018-06-01 PHASE3
NCT03629262 COMPLETED
Elderly; Orthopedic Surgery; Analgesia; Dexmedetomidine; Postoperative Delirium; Long-term Outcome
Peking University First Hospital
 2018-10-28 PHASE4
NCT03793751 COMPLETED
Cognitive Dysfunction
Tata Main Hospital
 2017-10-01 PHASE4
NCT03892512 UNKNOWN
Cognitive Dysfunction
Beni-Suef University
 2019-04 PHASE1; PHASE2
NCT03385967 WITHDRAWN
Analgesia; Pain, Acute; Peripheral Nerve Block
University of Florida
 2019-04 PHASE4
NCT04027829 COMPLETED
Intensive Care Unit; Postoperative Care
Seoul National University Hospital
 2019-08-14 PHASE2
NCT03714919 COMPLETED
Adenoid Hypertrophy
Arlyne Thung
 2019-08-02 PHASE2
NCT04037774 UNKNOWN
Drug Effect
Services Institute of Medical Sciences, Pakistan
 2019-09-02 PHASE4
NCT02454881 COMPLETED
Pain, Postoperative
Turku University Hospital
 2015-06 PHASE4
NCT03335527 COMPLETED
Aged; Postoperative Period; Intensive Care Units; Mechanical Ventilation Complication; Sleep Disorders; Dexmedetomidine
Peking University First Hospital
 2017-11-17 PHASE4
NCT03735368 COMPLETED
Conscious Sedation
Abd-Elazeem Abd-Elhameed Elbakry
 2018-12-10 PHASE2
NCT03378973 TERMINATED
Spinal Fusion
Hospital for Special Surgery, New York
 2018-11-28 PHASE4
NCT03234660 COMPLETED
Dexmedetomidine
Seoul National University Hospital
 2017-09-01
NCT04171349 COMPLETED
Renal Failure
Ain Shams University
 2019-06-01 EARLY_PHASE1
NCT03170739 UNKNOWN
Renal Function
Tao Zhang
 2017-06-06 PHASE4
NCT03327389 UNKNOWN
Kidney Transplantation
Yonsei University
 2017-11-01
NCT03290625 COMPLETED
Caries of Infancy; Dental Anxiety
Universidade Federal de Goias
 2017-11-09 PHASE4
NCT04058899 UNKNOWN
Emergence Delirium
Ain Shams University
 2019-03-05 PHASE1; PHASE2
NCT02820610 COMPLETED
Analgesia
Assiut University
 2016-08 PHASE2
NCT03926663 UNKNOWN
Intranasal Dexmedetomidine; Intranasal Bupivacaine; Septoplasty Surgeries
Cairo University
 2019-07-20 PHASE4
NCT03827408 COMPLETED
Dental Anxiety
Nourhan M.Aly
 2017-11-27 PHASE2
NCT03155646 COMPLETED
Transversus Abdominis Plane Block
Assiut University
 2017-06-10 PHASE2; PHASE3
NCT04010305 COMPLETED
Agitation; Schizophrenia
BioXcel Therapeutics Inc
 2019-05-22 PHASE1
NCT03885804 COMPLETED
Pain, Postoperative
Ain Shams University
 2019-03-20 EARLY_PHASE1
NCT05451121 COMPLETED
Respiratory Failure; Mechanical Ventilation Complication; Sedation Complication
Anesthesia Research Group UA
 2017-07-01
NCT03370588 COMPLETED
Colon Cancer
Yonsei University
 2017-12-01
NCT03453424 COMPLETED
Abdominal Pain; Abdominal Cancer
South Egypt Cancer Institute
 2017-06-30 PHASE2; PHASE3
NCT03610893 COMPLETED
Pain, Postoperative; Pain, Acute; Upper Extremity Injury
University of Chile
 2018-08-16
NCT05091151 COMPLETED
Anesthesia; Deep Sedation; Magnetic Resonance Imaging; Pediatric ALL
Indonesia University
 2019-02-01
NCT03622502 COMPLETED
Cough
Ajou University School of Medicine
 2018-08-16
NCT03738059 UNKNOWN
Skull Pin Insertion
Assiut University
 2018-11-15 EARLY_PHASE1
NCT03477994 COMPLETED
Delirium on Emergence
Ain Shams University
 2018-12-01
NCT03760809 COMPLETED
Agitated; State, Acute Reaction to Stress
Eye & ENT Hospital of Fudan University
 2019-01-04 PHASE4
NCT03436472 COMPLETED
Aged; Operative; Delirium; Dexmedetomidine; Mortality; Long-term Survivors
Peking University First Hospital
 2017-06-01
NCT02170948 TERMINATED
Anesthesia
University Health Network, Toronto
 2014-04
NCT03940469 COMPLETED
Postoperative Analgesia; Postoperative Complications
Menoufia University
 2016-07-03 PHASE4
NCT01050699 COMPLETED
Critical Illness; Sleep; Acute Lung Injury; Acute Respiratory Distress Syndrome
University of Arizona
 2009-08 PHASE4
NCT03346226 UNKNOWN
Delirium in Old Age
Shanghai Zhongshan Hospital
 2018-01-01 PHASE4
NCT03337672 COMPLETED
Tonsillitis
Eunah Cho, MD
 2017-12-05
NCT03629483 TERMINATED
Elderly; Knee Arthroplasty; Nerve Block; Dexmedetomidine; Postoperative Delirium; Long-term Outcome
Peking University First Hospital
 2018-12-10 PHASE4
NCT03393988 UNKNOWN
Anesthesia
Ain Shams University
 2017-12-07 PHASE4
NCT03363425 UNKNOWN
Hysterectomy; Myomectomy
University of Athens
 2017-11-14 PHASE2; PHASE3
NCT03402113 UNKNOWN
Hypercatabolism; Sedative, Hypnotic, or Anxiolytic Use Disorders
Chinese Medical Association
 2017-12-20
NCT03498092 COMPLETED
Postoperative Pain
Alaa Mazy
 2016-08-08
NCT03817112 COMPLETED
Regional Cerebral Tissue Oxygen Saturation
Ain Shams University
 2017-06-15
NCT03996148 COMPLETED
Carotid Artery Stenosis
The Cooper Health System
 2017-09-29 PHASE4
NCT03024957 UNKNOWN
Immune System Suppression
Assiut University
 2017-01 PHASE1; PHASE2
NCT03156296 COMPLETED
Laparoscopic Orcheopexy
Assiut University
 2017-06-10 PHASE2
NCT03312413 UNKNOWN
Anesthesia Complication
Min Su
 2017-08-10 PHASE4
NCT03322150 TERMINATED
Spinal Anesthesia
Yonsei University
 2017-10-01
NCT02965586 UNKNOWN
Postoperative Shivering
Assiut University
 2016-11 PHASE1; PHASE2
NCT03480789 UNKNOWN
Metabolic Problems; Sleep
Chinese Medical Association
 2018-02-05
NCT02604940 COMPLETED
Pain
West Virginia University
 2014-08 PHASE4
NCT03324490 COMPLETED
Nephrectomy; Lung Diseases; Anesthesia
Nazmy Edward Seif
 2017-11-01
NCT03813277 COMPLETED
ICU Sedation
Orion Corporation, Orion Pharma
 2017-03-21 PHASE4
NCT03463083 COMPLETED
Dexmedetomidine VS Fentanyl as Adjuvants to Epidural Bupivacaine in Patients Undergoing Lumbar Spine Surgeries
Cairo University
 2018-03-04
NCT03415724 UNKNOWN
Irreversible Pulpitis
Postgraduate Institute of Dental Sciences Rohtak
 2018-02-01
NCT03270033 COMPLETED
Pain, Postoperative; Shoulder Joint Disorder; Ambulatory Surgical Procedures; Brachial Plexus Block
University of Manitoba
 2017-09-18 PHASE4
NCT03253224 TERMINATED
Arthritis Knee; Magnesium Sulfate; Dexmedetomidine
Seoul National University Hospital
 2017-09-10 PHASE4
NCT03451227 TERMINATED
Tachyarrhythmia
University Health Network, Toronto
 2017-12-01
NCT03302351 COMPLETED
Shivering
Assiut University
 2017-10-01 PHASE4
NCT03775876 COMPLETED
Hemodynamic; Sedation; Satisfaction, Personal
Saint-Joseph University
 2017-03-01 PHASE4
NCT03151668 UNKNOWN
Septic Shock
Cairo University
 2017-01-04 PHASE3
NCT02678728 COMPLETED
Chronic Dissecting Aneurysm of Thoracic Aorta; Chronic Nontraumatic Dissection of Thoracic Aorta; Dissecting Aneurysm of the Thoracic Aorta
Gangnam Severance Hospital
 2016-02 PHASE4
NCT03143972 COMPLETED
Anesthesia
University Medical Center Groningen
 2017-06-28 PHASE4
NCT02985697 UNKNOWN
Safety and Efficacy of Intranasal Dexmedetomidine
Bon Secours Pediatric Dental Associates
 2017-01 PHASE4
NCT03096730 COMPLETED
Pain; Anesthesia
Tianjin Medical University General Hospital
 2017-02-06
NCT03551067 COMPLETED
Adenotonsillectomy
Suez Canal University
 2016-08-01 PHASE4
NCT03171740 COMPLETED
Emergence Delirium
Brasilia University Hospital
 2017-06-01 PHASE3
NCT02250820 COMPLETED
Heart Disease
Children's Hospital Medical Center, Cincinnati
 2014-11 PHASE1
NCT03375385 COMPLETED
Adverse Effects in the Therapeutic Use of Other and Unspecified Agents Primarily Acting on the Respiratory System
Ain Shams University
 2016-09 PHASE4
NCT03212495 COMPLETED
Knee Injuries
Assiut University
 2017-08-01 PHASE2; PHASE3
NCT02641938 COMPLETED
Malignant Tumor
Gangnam Severance Hospital
 2015-12 PHASE4
NCT02150759 COMPLETED
Pain
Inje University
 2014-05
NCT02512809 TERMINATED
Toxicity; Hydrocephalus
Nationwide Children's Hospital
 2015-07 PHASE3
NCT01915277 COMPLETED
Transposition of the Great Arteries; Tetralogy of Fallot; Ventricular Septal Defect
Carelon Research
 2014-04-02 PHASE1
NCT03013634 UNKNOWN
Evidence of Liver Transplantation; Myocardial Injury
Tianjin First Central Hospital
 2016-10
NCT03065530 COMPLETED
Breast Feeding; Analgesia Obstetrical; Postoperative Pain
The First Affiliated Hospital with Nanjing Medical University
 2017-02-07 PHASE4
NCT03126422 UNKNOWN
Fentanyl-induced Cough
Yangzhou University
 2017-05-01 PHASE1
NCT02353169 COMPLETED
Myocardial Repolarization; Healthy
University of British Columbia
 2015-09 PHASE4
NCT02843698 COMPLETED
Restrictive Lung Disease
Cairo University
 2016-09 PHASE4
NCT03172897 SUSPENDED
Adult Disease; Intensive Care Unit Syndrome; Mechanical Ventilation Complication; Delirium; Dexmedetomidine
Peking University First Hospital
 2017-08-20 PHASE4
NCT02563288 UNKNOWN
Intracranial Aneurysm; Intracranial Neoplasms
George Papanicolaou Hospital
 2016-08 PHASE3
NCT03131375 COMPLETED
Emergence Delirium; Extubation Time; Heart Rate; Postoperative Analgesia; Blood Pressure
Athens General Children's Hospital "Pan. & Aglaia Kyriakou"
 2017-05-01 PHASE2; PHASE3
NCT03108937 COMPLETED
Breast Cancer
RenJi Hospital
 2017-04-12
NCT02953054 COMPLETED
Pain, Postoperative
Teikoku Pharma USA, Inc.
 2017-01-22 PHASE2
NCT02902380 COMPLETED
Spinal Stenosis
Yonsei University
 2016-09-27
NCT02773797 WITHDRAWN
COPD
Dayton VA Medical Center
 2016-08 PHASE4
NCT03135795 UNKNOWN
Epigenetics
Huazhong University of Science and Technology
 2017-02-06 PHASE4
NCT02757625 COMPLETED
ICU Sedation
Pfizer
 2016-07-20 PHASE3
NCT03174678 COMPLETED
Premedication
Aydin Adnan Menderes University
 2017-03-01 PHASE4
NCT02874378 UNKNOWN
Renal Failure
First Affiliated Hospital Xi'an Jiaotong University
 2016-10
NCT03163693 UNKNOWN
Coronary Artery Bypass, Off-Pump
General Hospital of Ningxia Medical University
 2016-02
NCT02523144 COMPLETED
Heart Disease
Children's Hospital Medical Center, Cincinnati
 2014-09 PHASE4
NCT01266252 COMPLETED
Mechanically-ventilated Neonates With Single-organ Respiratory Failure
University Hospital, Ghent
 2011-07-28 PHASE3
NCT02624401 COMPLETED
Anesthesia; Unconsciousness
University of Turku
 2016-01 PHASE4
NCT03067740 UNKNOWN
Pain, Postoperative
Zagazig University
 2016-06 PHASE4
NCT02818985 COMPLETED
Postoperative Pain
Assiut University
 2016-06 PHASE2
NCT02833688 COMPLETED
Ischemia-reperfusion Injury
Chinese PLA General Hospital
 2016-08-02 PHASE4
NCT01766089 COMPLETED
Pregnancy; Severe Pre-eclampsia
Mansoura University
 2013-01 PHASE2
NCT02809937 COMPLETED
Aged; Surgical Procedures, Operative; Delirium; Dexmedetomidine; Mortality; Long-term Survivors
Peking University First Hospital
 2011-05 PHASE4
NCT02917018 COMPLETED
Stress Response
Assiut University
 2016-05 PHASE2; PHASE3
NCT02927379 COMPLETED
Abdominal Cancer
Assiut University
 2016-06 PHASE3
NCT02658760 UNKNOWN
Femoral Fractures
Hamidreza Mahboobi
 2015-06 PHASE3
NCT02853864 COMPLETED
Anesthesia
Guangzhou General Hospital of Guangzhou Military Command
 2016-08 PHASE4
NCT02475824 COMPLETED
Complication
Dankook University
 2015-05 PHASE4
NCT01664520 COMPLETED
Subarachnoid Hemorrhage; Aneurysm
Turku University Hospital
 2013-06 PHASE1; PHASE2
NCT03143244 COMPLETED
Retinal Surgery
Mansoura University
 2016-01-01 PHASE4
NCT02203019 COMPLETED
Sepsis; Respiratory Failure; Agitation
Texas Tech University Health Sciences Center
 2014-08 PHASE4
NCT02845661 UNKNOWN
Anesthesia
Guangzhou General Hospital of Guangzhou Military Command
 2016-06 PHASE4
NCT02784626 COMPLETED
Arthritis, Degenerative
Seoul National University Bundang Hospital
 2016-05 PHASE4
NCT02250703 COMPLETED
Preoperative Sedation
University of Mississippi Medical Center
 2014-09 PHASE3
NCT02684019 COMPLETED
Lack of Drug Action
Theodor Bilharz Research Institute
 2016-01 PHASE3
NCT02739958 COMPLETED
Cancer Larynx; Total Laryngectomy
Mansoura University
 2016-03-01
NCT02510612 UNKNOWN
Diabetes
Shaanxi Provincial People's Hospital
 2015-08 PHASE4
NCT02535273 UNKNOWN
Spinal Diseases; Local Anesthesia
Tang-Du Hospital
 2015-09 PHASE4
NCT02844894 UNKNOWN
Intubation
Ufuk University
 2016-06 PHASE4
NCT02550795 COMPLETED
Postoperative Nausea and Vomiting
Gachon University Gil Medical Center
 2015-09
NCT02518789 UNKNOWN
Myoclonus
Tang-Du Hospital
 2015-09 PHASE4
NCT01981369 COMPLETED
Postoperative Pain
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
 2014-01
NCT02724098 COMPLETED
Pain
Turku University Hospital
 2016-04 PHASE4
NCT02674737 UNKNOWN
Postoperative Sedation,Gastrectomy, Enhanced Recovery After Surgery
Chinese Medical Association
 2016-01
NCT02691598 UNKNOWN
Pancreatitis, Acute Necrotizing
Nanjing University School of Medicine
 2016-02 PHASE4
NCT02810899 COMPLETED
Brain Neoplasms
Peking University First Hospital
 2015-09 PHASE4
NCT01889004 COMPLETED
Consciousness, Level Altered
University of Turku
 2014-02 PHASE4
NCT04398589 COMPLETED
Suprascapular Nerve Block; Axillary Nerve Block; Dexmedetomidine; Arthroscopic Rotator Cuff Repair; Postoperative Pain; Pain Related Cytokine
Chuncheon Sacred Heart Hospital
 2015-05-20 PHASE4
NCT02117726 UNKNOWN
Delirium
Shandong Provincial Hospital
 2014-05 PHASE4
NCT02670954 COMPLETED
Postoperative Sedation, Abdominal Surgery
Chinese Medical Association
 2015-10
NCT02464722 UNKNOWN
Hemodynamic Instability
Korea University Anam Hospital
 2015-08 PHASE4
NCT02472522 COMPLETED
Pregnancy
Tata Main Hospital
 2015-05
NCT02715154 COMPLETED
Cesarean Section, Affecting Fetus or Newborn
The First Affiliated Hospital with Nanjing Medical University
 2015-06 PHASE1
NCT02801188 COMPLETED
Fracture of Proximal Femur
Mansoura University
 2014-10-01
NCT02331563 WITHDRAWN
Postoperative Nausea and Vomiting
Kırıkkale University
 2014-10 PHASE3
NCT02141412 COMPLETED
Anesthesia Recovery; Anesthesia Emergence; Shivering; Postoperative Recovery
American University of Beirut Medical Center
 2009-09 PHASE4
NCT02488473 COMPLETED
Healthy
Zealand University Hospital
 2015-08 PHASE2
NCT02064530 COMPLETED
Pain
TC Erciyes University
 2014-02 PHASE4
NCT02316236 COMPLETED
Anesthesia
Air Force Military Medical University, China
 2014-12-10
NCT02267538 COMPLETED
Delirium; C.Surgical Procedure; Cardiac; Postoperative Complications
Peking University First Hospital
 2014-11 PHASE4
NCT02365857 COMPLETED
Anesthesia, Spinal
Cairo University
 2014-12 PHASE4
NCT02208505 COMPLETED
Thyroidectomy
Yonsei University
 2014-02 PHASE4
NCT02284243 COMPLETED
Pain, Post-operative
Baudax Bio
 2014-10 PHASE2
NCT02134093 UNKNOWN
Postoperative Confusion
Tang-Du Hospital
 2014-07 PHASE4
NCT02122055 UNKNOWN
Mechanical Ventilation Complication
Tianjin Third Central Hospital
 2014-06 PHASE4
NCT02089932 COMPLETED
Dexmedetomidine; Femoral Nerve Block; Arthroscopic Knee Surgery
Cairo University
 2014-02 PHASE4
NCT02386462 UNKNOWN
Anesthesia
Guangzhou General Hospital of Guangzhou Military Command
 2014-11 PHASE4
NCT03078946 COMPLETED
Delirium
Ain Shams University
 2013-03 PHASE4
NCT01976754 COMPLETED
Sepsis; Agitation
First Affiliated Hospital of Zhejiang University
 2013-09
NCT01722409 COMPLETED
Intracranial Aneurysms
China Medical University, China
 2012-12 PHASE4
NCT02289261 COMPLETED
Chronic Pain
Cukurova University
 2014-11 PHASE4
NCT02031510 COMPLETED
Elective Laparoscopic Cholecystectomy
Imam Abdulrahman Bin Faisal University
 2014-01 PHASE1; PHASE2
NCT02164448 COMPLETED
Gastric Cancer Patients Undergoing Laparoscopic Gastrectomy
Yonsei University
 2014-06 PHASE4
NCT02496650 COMPLETED
Alcohol Withdrawal State
Bogomolets National Medical University
 2013-01 PHASE4
NCT02142595 COMPLETED
Sleep Quality of Patients Undergoing TURP
China Medical University, China
 2014-05 PHASE4
NCT02007798 UNKNOWN
Brain Neoplasms; Surgery
China Medical University, China
 2014-01
NCT01687751 WITHDRAWN
Pain Intractable; Delirium; Dyspnea; Nausea
Fraser Health
 2012-11 PHASE2
NCT02169843 UNKNOWN
Emergence Agitation
Tang-Du Hospital
 2014-05 PHASE4
NCT01283412 UNKNOWN
Delirium, Postoperative
Huazhong University of Science and Technology
 2013-06 PHASE3
NCT02299232 COMPLETED
Anesthesia
Sisli Hamidiye Etfal Training and Research Hospital
 2014-02 PHASE4
NCT01901588 COMPLETED
Strabismus; Delirium on Emergence; Pediatric Disorders
NYU Langone Health
 2012-03 PHASE4
NCT01269918 COMPLETED
Adult Intracranial Tumor; Adult Solid Tumor
The Cleveland Clinic
 2011-07
NCT01851005 COMPLETED
Elderly Patients; Anesthesia; Emergence From Anesthesia; Effects of Dexmedetomidine; Recovery From Anesthesia
Chosun University Hospital
 2013-05
NCT03323593 COMPLETED
Bioavailability; Dexmedetomidine
The University of Hong Kong
 2013-05 PHASE3
NCT01447875 COMPLETED
Shock; Sepsis
Southeast University, China
 2011-05 PHASE1
NCT01979653 WITHDRAWN
Sedation; Aged; Hemodynamics
Severance Hospital
 2013-11
NCT01535287 COMPLETED
Myringotomy
Martin Mueller
 2011-01-04 PHASE4
NCT01937611 UNKNOWN
Laryngoscopy; Preanesthetic Medication
Guangzhou First People's Hospital
 2013-03 PHASE4
NCT02109510 COMPLETED
Primary Spontaneous Pneumothorax
Korea University
 2012-11
NCT01665586 COMPLETED
Benign Prostate Hyperplasia; Bladder Tumor
Yonsei University
 2012-03
NCT05342870 COMPLETED
Bier Block; Dexmedetomidine; Tourniquet Pain; Carpal Tunnel; Tendon Release; Tendn Transfer
American University of Beirut Medical Center
 2012-08
NCT01852539 COMPLETED
Drug Usage
Ajou University School of Medicine
 2013-07 PHASE4
NCT03809182 COMPLETED
Bariatric Surgery Candidate; Glucose Intolerance; Insulin Resistance
Pontificia Universidad Catolica de Chile
 2012-09-27 PHASE4
NCT01948336 COMPLETED
Renal Function Disorder; Hemodynamic Instability
TC Erciyes University
 2012-04 PHASE4
NCT01645098 COMPLETED
Duchenne Muscular Dystrophy
Nationwide Children's Hospital
 2011-08
NCT01083797 COMPLETED
Other Conditions of Brain
Federal University of Minas Gerais
 2009-12 PHASE3
NCT01805726 COMPLETED
Bronchoscopy; Conscious Sedation
Saint-Joseph University
 2013-02 PHASE3
NCT01956981 COMPLETED
Hemorrhage
TC Erciyes University
 2012-01 PHASE4
NCT01001429 COMPLETED
Retinal Detachment
Rutgers, The State University of New Jersey
 2009-10 PHASE4
NCT01688648 COMPLETED
Unstable Angina; Coronary Artery Bypass Graft; Dexmedetomidine; Lidocaine; Myocardial Injury; Arrhythmia; Blood Electrolyte Balance
Samsung Medical Center
 2012-09
NCT00871624 COMPLETED
Acute Respiratory Failure
Tufts Medical Center
 2009-03 PHASE2
NCT01578161 UNKNOWN
Psychomotor Agitation
Seoul National University Hospital
 2012-01 PHASE4
NCT01524367 COMPLETED
Agitation
Yonsei University
 2011-10 PHASE4
NCT01918917 COMPLETED
Pain
TC Erciyes University
 2011-07 PHASE4
NCT00351299 COMPLETED
Delirium; Agitation
Brigham and Women's Hospital
 2006-01 PHASE2
NCT00744380 COMPLETED
Critical Illness
University of Colorado, Denver
 2008-08
NCT01365923 COMPLETED
Open Craniotomy
Yonsei University
 2011-05 PHASE4
NCT00691886 WITHDRAWN
Pain
Lahey Clinic
 2008-04 PHASE4
NCT01158820 COMPLETED
Sedation
University of Pennsylvania
 2010-06 PHASE4
NCT01404689 COMPLETED
Undergoing ERCP for Diagnostic or Therapeutic Purposes
Seoul National University Hospital
 2011-08 PHASE4
NCT01691001 COMPLETED
Ambulation Difficulty
Yonsei University
 2011-08
NCT00608231 WITHDRAWN
Parkinson's Disease; Essential Tremor; Dystonia
Vanderbilt University
 2008-01 PHASE2; PHASE3
NCT01474213 COMPLETED
Intubation; Difficult
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
 2011-11 PHASE4
NCT01921361 COMPLETED
Perioperative/Postoperative Complications
TC Erciyes University
 2011-01 PHASE4
NCT01517932 COMPLETED
Restlessness; Pain
Fang Luo
 2011-06 PHASE4
NCT01289769 COMPLETED
Intubation Complication; Tracheal Intubation Morbidity; Anesthesia Intubation Complication; Hypertension; High Blood Pressure; Tachycardia
Chiang Mai University
 2011-03 PHASE2
NCT01438957 COMPLETED
Sedation
Pfizer
 2011-06-03 PHASE3
NCT01344759 COMPLETED
Sleep Apnea, Obstructive
Children's Hospital Medical Center, Cincinnati
 2009-06 PHASE4
NCT01342562 COMPLETED
Benign Prostatic Hypertrophy
Yonsei University
 2010-11
NCT01256866 UNKNOWN
Mechanically Ventilated Patients; Sedation; Dexmedetomidine; Midazolam
Hospital Sao Domingos
 2010-11 PHASE4
NCT01353378 WITHDRAWN
Delirium
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
 2011-06 PHASE4
NCT01378988 COMPLETED
Sedation; Pain
Hospira, now a wholly owned subsidiary of Pfizer
 2011-06 PHASE2
NCT00932386 WITHDRAWN
Orthopedic/Podiatry Procedures
Rutgers, The State University of New Jersey
 2009-07 PHASE4
NCT01076790 COMPLETED
Anaesthesia
Arvi Yli-Hankala
 2009-11 PHASE4
NCT01070680 COMPLETED
Pancreatitis
Helsinki University Central Hospital
 2010-03 PHASE4
NCT01224470 COMPLETED
Transurethral Prostatectomy
Yonsei University
 2010-11
NCT01065701 COMPLETED
Patient Between 1-8 Years Old Undergoing Elective Surgery at Queen Mary Hospital
The University of Hong Kong
 2009-07 PHASE3
NCT01084473 COMPLETED
Gastric Emptying; Healthy
University of Turku
 2010-03 PHASE1
NCT00494832 COMPLETED
Spine Surgery
University of Washington
 2008-02
NCT04628559 COMPLETED
Anesthesia; Intravenous Anesthetic Toxicity
Karadeniz Technical University
 2009-07-01
NCT00455143 TERMINATED
Postoperative Delirium; PD; Postoperative Cognitive Dysfunction; POCD
Icahn School of Medicine at Mount Sinai
 2006-09 PHASE4
NCT00671931 COMPLETED
Scoliosis
Children's Hospital Medical Center, Cincinnati
 2007-04 PHASE1
NCT00747721 COMPLETED
Pharmacokinetics; Sedation
Orion Corporation, Orion Pharma
 2008-09 PHASE1
NCT00646646 COMPLETED
Saccadic Eye Movements
University of Alabama at Birmingham
 2007-04
NCT00142493 COMPLETED
Memory Losses; Amnesia-Memory Loss
Memorial Sloan Kettering Cancer Center
 2004-09 PHASE1
NCT00538616 COMPLETED
Brain Injury; Intracranial Pressure
Carmelo Graffagnino
 2008-01 PHASE1; PHASE2
NCT01491009 COMPLETED
Postoperative Cognitive Functions
Gazi University
 2006-05
NCT00383890 COMPLETED
Awake Fiberoptic Intubation
Hospira, now a wholly owned subsidiary of Pfizer
 2006-08 PHASE3
NCT00641563 COMPLETED
Conscious Sedation; Deep Sedation; Critical Care
Insel Gruppe AG, University Hospital Bern
 2004-03
NCT00398827 COMPLETED
Anesthesia; Surgical Procedures, Elective
Hospira, now a wholly owned subsidiary of Pfizer
 2006-12 PHASE3
NCT00226785 TERMINATED
Conscious Sedation
Orion Corporation, Orion Pharma
 2005-10 PHASE3
NCT00338546 WITHDRAWN
Cocaine Induced Sympathoexciation and Vasoconstriction
University of Texas Southwestern Medical Center
 PHASE1
NCT00216190 COMPLETED
Mechanically Ventilated and Intubated Subjects
Hospira, now a wholly owned subsidiary of Pfizer
 2005-03 PHASE4
NCT00333632 WITHDRAWN
Sleep
Duke University
 2006-06 PHASE4

(data from https://clinicaltrials.gov, updated on 2025-10-28)

Check the Dexmedetomidine HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Dexmedetomidine HCl functions as a highly selective alpha-2 adrenoceptor agonist that selectively binds to presynaptic alpha-2 adrenergic receptors, inhibiting adenylate cyclase activity and reducing intracellular cyclic AMP levels to diminish central sympathetic outflow. This suppression of central noradrenergic neurotransmission induces sedation, anxiolysis, and analgesia, providing clinically relevant reductions in anesthetic requirements, perioperative hemodynamic reactivity, and postoperative shivering.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.