CAS No. 50-02-2
| IUPAC Name | (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one | |
|---|---|---|
| CAS Number | 50-02-2 | |
| Molecular Formula |
C22H29FO5 |
|
| Molecular Weight (MW) | 392.46 | |
| SMILES | CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C | |
| InChIKey | UREBDLICKHMUKA-CXSFZGCWSA-N |
Dexamethasone is a synthetic glucocorticoid receptor agonist that functions as a potent anti-inflammatory and immunosuppressant agent. Upon binding to the glucocorticoid receptor, it modulates signaling through pathways such as NF-kB and interleukin networks. Downstream, dexamethasone inhibits pro-inflammatory cytokine expression while promoting autophagy and mitophagy, contributing to suppressed cellular immune responses and enhanced cellular stress adaptation. [1]
| Solvent | Solubility & Note |
|---|---|
| DMSO |
78 mg/mL
(198.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 11 mg/mL |
| Water | Insoluble |
| DMSO |
79 mg/mL
(201.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
| DMSO |
78 mg/mL
(198.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
| DMSO |
200 mg/mL
(509.6 mM)
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 20 mg/mL |
| Water | Insoluble |
| DMSO |
79 mg/mL
(201.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 7 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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