Target Selectivity of BMS-986165 (Deucravacitinib)
| Key Target | IC50 | Description | Reference |
|---|---|---|---|
| TYK2 | 0.2 nM | probe displacement assay | PMC8484413 |
| TYK2 pseudokinase domain Janus homology 2 (JH2) | 0.2 nM | -- | PMC11344170 |
| IL-12 | 2 nM | In vitro, IL-12-driven cellular signalling and transcriptional responses | PMC10912518 |
| IL-23 | 2 nM | In vitro, IL-23-driven cellular signalling and transcriptional responses | PMC10912518 |
| IFN-I | 2 nM | In vitro, type 1 IFN-driven cellular signalling and transcriptional responses | PMC10912518 |
| IL-17 | 2 nM | Inhibition of IL-23-mediated phosphorylation of STAT3 in CD161+ CD3+ TH17 cells in human peripheral blood mononuclear cells, resulting in inhibition of IL-17 production by CD4+ T cells | PMC10912518 |
| IFN-α | 6 nM | Inhibition of IFN-α-stimulated gamma-induced protein production in human peripheral blood mononuclear cells | PMC10912518 |
| Janus homology 1 (JH1) in the JAK family | 10000 nM | -- | PMC11344170 |
| TYK2 | 10000 nM | Cell-based assays (TYK2 Active Domain) | PMC10912518 |
| JAK1 | 10000 nM | Cell-based assays | PMC10912518 |
| JAK2 | 10000 nM | Cell-based assays | PMC10912518 |
| JAK3 | 10000 nM | Cell-based assays | PMC10912518 |
| JAK 1 | 10 µM | in vitro kinase binding assays | PMC8484413 |
| JAK2 | 10 µM | in vitro kinase binding assays | PMC8484413 |
| JAK3 | 10 µM | in vitro kinase binding assays | PMC8484413 |
Check the
BMS-986165 (Deucravacitinib)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Cell-free Assays (IC50/Ki) for BMS-986165 (Deucravacitinib)
| Key Target | IC50 (Cell-free) | Description | Reference |
|---|---|---|---|
| JAK 1/3 (IL-2–induced pSTAT5) | 1.646 µM | Flow cytometric analysis (FACS Canto II) of phosphorylated STAT5 expression (MFI) after gating on CD3-positive T cells. | PMC8484413 |
| JAK 2/2 (TPO-induced pSTAT3) | >10 µM | Flow cytometric analysis of phosphorylated STAT3 expression (MFI) after gating on CD61-positive platelets. | PMC8484413 |
| TYK2/JAK 2 (IL-12–induced IFN-c release) | 42 nM | BD OptEIA human IFN-c enzyme-linked immunosorbent assay kit for IFN-c levels. | PMC8484413 |
| TYK2 enzyme | 0.2 nM | probe displacement assay | PMC8484413 |
| JAK 1/2/3 | >10 µM | in vitro kinase binding assays | PMC8484413 |
Cell-based Assay (IC50) for BMS-986165 (Deucravacitinib)
| Cell Type | IC50 (Cell-based) | Description | Reference |
|---|---|---|---|
| HaCaT cells | 8.23 ± 1.38 mg/ml | CCK8 assay | Download PDF |
| THP-1 cells | 1.2 nM | Measuring pSTAT5 abundance in response to IFNα stimuli | PMC12002270 |
| PBMC | 6.2 nM | Measuring IL-12-induced pSTAT4 | PMC12002270 |
Jump to
- BMS-986165 (Deucravacitinib) Mechanism of Action: TYK2 Inhibition in Immune Cell Research
- BMS-986165 (Deucravacitinib) Clinical Trials
- BMS-986165 (Deucravacitinib) Working Concentration | Cell Culture | Treatment
- BMS-986165 (Deucravacitinib) Solubility in DMSO
- BMS-986165 (Deucravacitinib) Stock Solution
- BMS-986165 (Deucravacitinib) Storage
- BMS-986165 (Deucravacitinib) Stability
- BMS-986165 (Deucravacitinib) Combination Database
- BMS-986165 (Deucravacitinib) Molecular Weight
- BMS-986165 (Deucravacitinib) SMILES
- BMS-986165 (Deucravacitinib) CAS Number
- BMS-986165 (Deucravacitinib) Chemical Structure (2D and 3D)
- BMS-986165 (Deucravacitinib) IC50 for Cell-based and Cell-free Assays
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- BMS-986165 (Deucravacitinib) SDS｜MSDS