BMS-986165 (Deucravacitinib) is a potent, highly selective, allosteric TYK2 inhibitor. It affects IL-12, IL-23, and type I interferon signaling by binding to the TYK2 pseudokinase domain (JH2) to block STAT phosphorylation, effectively inhibiting inflammatory responses and abnormal cell proliferation.
BMS-986165 (Deucravacitinib) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for BMS-986165 (Deucravacitinib) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.