CAS No. 1234356-69-4

Batch: Purity:99.91
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Derazantinib Chemical Structure
Chemical Structure
Check the Derazantinib product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (6R)-6-(2-fluorophenyl)-N-[3-[2-(2-methoxyethylamino)ethyl]phenyl]-5,6-dihydrobenzo[h]quinazolin-2-amine
CAS Number 1234356-69-4
Molecular Formula

C29H29FN4O
Molecular Weight (MW) 468.57
SMILES COCCNCCC1=CC(=CC=C1)NC2=NC=C3CC(C4=CC=CC=C4C3=N2)C5=CC=CC=C5F
InChIKey KPJDVVCDVBFRMU-AREMUKBSSA-N

Ordering Information

Biological Activity

Derazantinib is an orally bioavailable pan-FGFR inhibitor targeting FGFR1 (IC50 4.5 nM), FGFR2 (IC50 1.8 nM), FGFR3 (IC50 4.5 nM), and FGFR4 (IC50 34 nM), with additional inhibitory activity against RET, DDR2, PDGFRβ, VEGFR, and KIT. By inhibiting FGFR autophosphorylation, derazantinib blocks downstream AKT/mTOR and ERK/MAPK signaling pathways, leading to suppressed cell proliferation and induced apoptosis in FGFR-dependent cancer cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 93 mg/mL (198.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.