CAS No. 681492-22-8

Batch: Purity:99.91
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Delamanid Chemical Structure
Chemical Structure
Check the Delamanid product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 681492-22-8
Molecular Formula

C25H25F3N4O6
Molecular Weight (MW) 534.48
SMILES CC1(CN2C=C(N=C2O1)[N+](=O)[O-])COC3=CC=C(C=C3)N4CCC(CC4)OC5=CC=C(C=C5)OC(F)(F)F

Ordering Information

Biological Activity

Delamanid (OPC-67683) is an anti-tuberculosis agent that inhibits mycolic acid synthesis in Mycobacterium tuberculosis. As a prodrug activated by the deazaflavin-dependent nitroreductase Rv3547, it selectively disrupts the biosynthesis of methoxy-mycolic and keto-mycolic acids. This inhibition impairs bacterial cell wall integrity, leading to potent intracellular bactericidal activity against drug-susceptible and multidrug-resistant bacterial strains.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (187.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.