CAS No. 67909-49-3
Batch:
Purity:99.72
Chemical Structure
Check the
Dehydroevodiamine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 21-methyl-3,13,21-triazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-1,3,5,7,9,15,17,19-octaen-14-one | |
|---|---|---|
| CAS Number | 67909-49-3 | |
| Molecular Formula |
C19H15N3O |
|
| Molecular Weight (MW) | 301.34 | |
| SMILES | CN1C2=CC=CC=C2C(=O)N3C1=C4C(=C5C=CC=CC5=N4)CC3 | |
| InChIKey | VXHNSVKJHXSKKM-UHFFFAOYSA-N |
Dehydroevodiamine is a bioactive alkaloid derived from Evodia rutaecarpa that acts as an anti-inflammatory agent. It inhibits lipopolysaccharide-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), suppressing downstream nitric oxide and prostaglandin E2 (PGE2) production. This biological activity is mediated through suppression of NF-kB pathway activation in macrophages, while also exhibiting cardiovascular effects including hypotensive and ion channel modulating properties. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
19 mg/mL
(63.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.