CAS No. 134418-28-3

Batch: Purity:99.99
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Dehydroandrographolide Chemical Structure
Chemical Structure
Check the Dehydroandrographolide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3E)-3-[2-[(1S,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]furan-2-one
CAS Number 134418-28-3
Molecular Formula

C20H28O4
Molecular Weight (MW) 332.43
SMILES CC12CCC(C(C1CCC(=C)C2CC=C3C=COC3=O)(C)CO)O
InChIKey YIIRVUDGRKEWBV-CZUXAOBFSA-N

Ordering Information

Biological Activity

Dehydroandrographolide is a natural diterpenoid isolated from Andrographis paniculata that acts as a transmembrane protein 16A (TMEM16A) inhibitor. By inhibiting TMEM16A calcium-activated chloride channel conductance, it modulates intracellular chloride ion transport and calcium-dependent signaling pathways. This targeted inhibition leads to downstream biological phenotypes, including the suppression of inflammatory responses, viral replication, and cell proliferation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 66 mg/mL (198.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 33 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.