Defactinib (VS-6063) is a potent, selective FAK and Pyk2 inhibitor. It affects FAK/Src and RAS/MAPK signaling pathways by blocking FAK phosphorylation at Y397/Y925, thereby inhibiting tumor cell proliferation, migration, and invasion.
Defactinib (VS-6063) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Defactinib (VS-6063) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.