Cell-free Assays (IC50/Ki) for Defactinib (VS-6063)
| Key Target | IC50 (Cell-free) | Description | Reference |
|---|---|---|---|
| FAK | 0.6 nM | In vitro inhibition assay | Download PDF |
| Pyk2 | 0.6 nM | In vitro inhibition assay | Download PDF |
Cell-based Assay (IC50) for Defactinib (VS-6063)
| Cell Type | IC50 (Cell-based) | Description | Reference |
|---|---|---|---|
| UTE1 | 1.9 μM | Cell viability quantified using flow cytometry (propidium iodide staining), IC50 values determined using GraphPad Prism 9. | Download PDF |
| UTE2 | 2.5 μM | Cell viability quantified using flow cytometry (propidium iodide staining), IC50 values determined using GraphPad Prism 9. | Download PDF |
| UTE3 | 1.7 μM | Cell viability quantified using flow cytometry (propidium iodide staining), IC50 values determined using GraphPad Prism 9. | Download PDF |
| UTE10 | 2.2 μM | Cell viability quantified using flow cytometry (propidium iodide staining), IC50 values determined using GraphPad Prism 9. | Download PDF |
| UTE11 | 3.8 μM | Cell viability quantified using flow cytometry (propidium iodide staining), IC50 values determined using GraphPad Prism 9. | Download PDF |
| MIA Paca-2 | 20.26 µM | XTT assay | Download PDF |
| BxPC-3 | 5.66 µM | XTT assay | Download PDF |
| Capan-1 | 4.17 µM | XTT assay | Download PDF |
| AsPC-1 | 12.34 µM | XTT assay | Download PDF |
| Beta-TC-3 | 9.30 µM | XTT assay | Download PDF |
| JIMT-1 | 73.7 nM | Tube formation assay | Download PDF |
| MDA-MB-231 | 152.0 nM | Tube formation assay | Download PDF |
| PC-9 | 1.5 μM | WST-8 assay | Download PDF |
Check the
Defactinib (VS-6063)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
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