CAS No. 1073154-85-4
Batch:
Purity:99.98
Chemical Structure
Check the
Defactinib (VS-6063)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide | |
|---|---|---|
| CAS Number | 1073154-85-4 | |
| Molecular Formula |
C20H21F3N8O3S |
|
| Molecular Weight (MW) | 510.49 | |
| SMILES | CNC(=O)C1=CC=C(C=C1)NC2=NC=C(C(=N2)NCC3=NC=CN=C3N(C)S(=O)(=O)C)C(F)(F)F | |
| InChIKey | FWLMVFUGMHIOAA-UHFFFAOYSA-N |
Biological Activity
Defactinib (VS-6063) is an orally bioavailable, small-molecule inhibitor of focal adhesion kinase (FAK). By targeted inhibition of FAK kinase activity, it disrupts downstream Src, AKT, and STAT3 signaling pathways, leading to suppressed tumor cell proliferation, migration, and invasive phenotype. Additionally, FAK inhibition reduces fibrotic extracellular matrix remodeling and impairs immunosuppressive cell infiltration within the tumor microenvironment. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(195.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(195.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(195.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
- Defactinib (VS-6063) Mechanism of Action: FAK Inhibition in Ovarian Cancer Cell Research
- Defactinib (VS-6063) Clinical Trials
- Defactinib (VS-6063) Working Concentration | Cell Culture | Treatment
- Defactinib (VS-6063) Solubility in DMSO
- Defactinib (VS-6063) Stock Solution
- Defactinib (VS-6063) Storage
- Defactinib (VS-6063) Stability
- Defactinib (VS-6063) Combination Database
- Defactinib (VS-6063) Molecular Weight
- Defactinib (VS-6063) SMILES
- Defactinib (VS-6063) Chemical Structure (2D and 3D)
- Defactinib (VS-6063) IC50 for Cell-based and Cell-free Assays
- Defactinib (VS-6063) Cayman (17737)? Try a better option.
- Defactinib (VS-6063) MedChemExpress (HY-12289)? Try a better option.
- Defactinib (VS-6063) Sigma (AMBH303C48C1)? Try a better option.
- Defactinib (VS-6063) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.