CAS No. 1073154-85-4
| IUPAC Name | N-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide | |
|---|---|---|
| CAS Number | 1073154-85-4 | |
| Molecular Formula |
C20H21F3N8O3S |
|
| Molecular Weight (MW) | 510.49 | |
| SMILES | CNC(=O)C1=CC=C(C=C1)NC2=NC=C(C(=N2)NCC3=NC=CN=C3N(C)S(=O)(=O)C)C(F)(F)F | |
| InChIKey | FWLMVFUGMHIOAA-UHFFFAOYSA-N |
Defactinib (VS-6063) is an orally bioavailable, small-molecule inhibitor of focal adhesion kinase (FAK). By targeted inhibition of FAK kinase activity, it disrupts downstream Src, AKT, and STAT3 signaling pathways, leading to suppressed tumor cell proliferation, migration, and invasive phenotype. Additionally, FAK inhibition reduces fibrotic extracellular matrix remodeling and impairs immunosuppressive cell infiltration within the tumor microenvironment. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(195.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(195.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(195.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(195.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(195.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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- Defactinib (VS-6063) Combination Database
- Defactinib (VS-6063) Molecular Weight
- Defactinib (VS-6063) SMILES
- Defactinib (VS-6063) Chemical Structure (2D and 3D)
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