CAS No. 82749-70-0
Batch:
Purity:99.99
Chemical Structure
Check the
DCPIB
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-[(2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-3H-inden-5-yl)oxy]butanoic acid | |
|---|---|---|
| CAS Number | 82749-70-0 | |
| Molecular Formula |
C22H28Cl2O4 |
|
| Molecular Weight (MW) | 427.36 | |
| SMILES | CCCCC1(CC2=CC(=C(Cl)C(=C2C1=O)Cl)OCCCC(O)=O)C3CCCC3 | |
| InChIKey | KHKGTPJPBOQECW-UHFFFAOYSA-N |
Biological Activity
DCPIB is a potent inhibitor of volume-regulated anion channels (VRAC), blocking native I(Cl,swell) in CPAE cells with an IC50 of 4.1 μM, and a selective inhibitor of TRESK channels with an IC50 of 0.14 μM while also inhibiting TASK1 and TASK3 channels. By blocking swelling-activated anion currents and two-pore domain potassium channels, DCPIB modulates cell volume homeostasis, membrane potential, and cellular electrical activity.[1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
85 mg/mL
(198.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 85 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.