Home Biosimilar Antibodies Immunology & Inflammation TROP2 Datopotamab (Anti-TROP2)
For research use only. Not for use in humans.

Datopotamab (Anti-TROP2)

Synonyms: CDP7657

Datopotamab (Anti-TROP2) is an antibody targeting to TROP2. It demonstrates potent antitumor activity and can be used in non-small cell lung cancer (NSCLC) research. MW :145.16 KD.

Datopotamab (Anti-TROP2)

Quality Control

Batch: Purity: 99% Protein concentration: 8.02mg/ml Endotoxin Level: ＜1EU/mg
99

Specificity

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description
Datopotamab (Anti-TROP2) is an antibody targeting to TROP2. It demonstrates potent antitumor activity and can be used in non-small cell lung cancer (NSCLC) research. MW :145.16 KD.
References

Product Details

CAS No. 2267989-53-5
Isotype Human IgG1
Source CHO
Formulation 100 mM Pro-Ac, 20mM Arg, pH5.0
Storage
(From the date of receipt)		 Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT07069595 RECRUITING Drug: Datopotamab deruxtecan Breast Cancer; Residual Disease; Triple Negative Breast Cancer (TNBC); Stage II/III UNC Lineberger Comprehensive Cancer Center 2026-02-26 PHASE2
NCT01042379 RECRUITING Drug: Standard Therapy|Drug: AMG 386 with or without Trastuz Breast Neoplasms; Breast Cancer; Breast Tumors; Angiosarcoma; TNBC - Triple-Negative Breast Cancer; HER2-positive Breast Cancer; HER2-negative Breast Cancer; Hormone Receptor Positive Tumor; Hormone Receptor Negative Tumor; Early-stage Breast Cancer; Locally Advanced Breast Cancer QuantumLeap Healthcare Collaborative 2010-03-01 PHASE2
NCT07720284 RECRUITING Drug: Dato-DXd|Drug: Rilvegostomig|Drug: Durvalumab|Drug: Ni High-risk Muscle Invasive Urothelial Carcinoma AstraZeneca 2026-07-16 PHASE3
NCT05215340 ACTIVE_NOT_RECRUITING Drug: Datopotamab Deruxtecan|Drug: Pembrolizumab Metastatic Non Small Cell Lung Cancer Daiichi Sankyo 2022-03-04 PHASE3
NCT06357533 RECRUITING Drug: Datopotamab Deruxtecan|Drug: Rilvegostomig|Drug: Pembr Non-Small Cell Lung Cancer AstraZeneca 2024-04-11 PHASE3
NCT07738341 NOT_YET_RECRUITING Drug: GB268|Drug: Nab-Paclitaxel|Drug: Datopotamab Deruxteca Breast Cancer (Locally Advanced or Metastatic) Eddingpharm (Zhuhai) Co., Ltd. 2026-08-01 PHASE1; PHASE2

(data from https://clinicaltrials.gov, updated on 2026-04-22)

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