CAS No. 302962-49-8
| IUPAC Name | N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide | |
|---|---|---|
| CAS Number | 302962-49-8 | |
| Molecular Formula |
C22H26ClN7O2S |
|
| Molecular Weight (MW) | 488.01 | |
| SMILES | CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO | |
| InChIKey | ZBNZXTGUTAYRHI-UHFFFAOYSA-N |
Dasatinib (BMS-354825) is an ATP-competitive, dual Src/Abl tyrosine kinase inhibitor that targets BCR-ABL and Src family kinases. By blocking oncogenic kinase signaling, dasatinib suppresses phosphorylation of downstream effectors, disrupting cell proliferation and survival pathways. It induces cell cycle arrest and apoptosis in leukemic cell lines and imatinib-resistant BCR-ABL mutants, demonstrating potent preclinical antitumor activity across various cancer models. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
98 mg/mL
(200.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
98 mg/mL
(200.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
98 mg/mL
(200.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
98 mg/mL
(200.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
98 mg/mL
(200.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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- Dasatinib (BMS-354825) Mechanism of Action: Src Kinase Inhibition in Senescent Cells Research
- Dasatinib (BMS-354825) Clinical Trials
- Dasatinib (BMS-354825): Selectivity & Specificity
- Dasatinib (BMS-354825) Working Concentration | Cell Culture | Treatment
- Dasatinib (BMS-354825) Solubility in DMSO
- Dasatinib (BMS-354825) Stock Solution
- Dasatinib (BMS-354825) Storage
- Dasatinib (BMS-354825) Stability
- Dasatinib (BMS-354825) Combination Database
- Dasatinib (BMS-354825) Molecular Weight
- Dasatinib (BMS-354825) SMILES
- Dasatinib (BMS-354825) Chemical Structure (2D and 3D)
- Dasatinib (BMS-354825) IC50 for Cell-based and Cell-free Assays
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