CAS No. 863127-77-9

Batch: Purity:99.62
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Dasatinib Monohydrate Chemical Structure
Chemical Structure
Check the Dasatinib Monohydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide;hydrate
CAS Number 863127-77-9
Molecular Formula

C22H28ClN7O3S
Molecular Weight (MW) 506.02
SMILES CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CCO.O
InChIKey XHXFZZNHDVTMLI-UHFFFAOYSA-N

Biological Activity

Dasatinib Monohydrate is a potent, multi-targeted tyrosine kinase inhibitor that targets Abl, Src, and c-Kit. By blocking BCR-ABL and Src family kinase activity, it disrupts oncogenic downstream signaling through the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR pathways. This inhibition suppresses cell proliferation, reduces cell survival, and induces apoptosis in BCR-ABL-dependent leukemic cells and imatinib-resistant mutants. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (197.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Shah NP, et al. Science. 2004;305(5682):399-401.

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Note: Technical data last updated: Sep 1, 2026.