CAS No. 80-08-0
Batch:
Purity:99.83
Chemical Structure
Check the
Dapson
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 80-08-0 | |
|---|---|---|
| Molecular Formula |
C12H12N2O2S |
|
| Molecular Weight (MW) | 248.30 | |
| SMILES | C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)N |
Biological Activity
Dapson (Dapsone) is a synthetic sulfone compound with antimicrobial and anti-inflammatory properties that targets dihydropteroate synthase (DHPS) in the bacterial folate synthesis pathway. By competing with para-aminobenzoic acid, it inhibits folate biosynthesis to impair microbial cell survival. Furthermore, Dapson suppresses myeloperoxidase activity and reduces reactive oxygen species production, resulting in decreased neutrophil recruitment and attenuated tissue injury during chronic inflammatory response pathways. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
49 mg/mL
(197.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.