CAS No. 244767-67-7

Batch: Purity:100
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Dapivirine (TMC120) Chemical Structure
Chemical Structure
Check the Dapivirine (TMC120) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[[4-(2,4,6-trimethylanilino)pyrimidin-2-yl]amino]benzonitrile
CAS Number 244767-67-7
Molecular Formula

C20H19N5
Molecular Weight (MW) 329.4
SMILES CC1=CC(=C(C(=C1)C)NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C
InChIKey ILAYIAGXTHKHNT-UHFFFAOYSA-N

Biological Activity

Dapivirine (TMC120) is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI) targeting HIV-1 reverse transcriptase. By binding to a hydrophobic pocket adjacent to the active site of viral reverse transcriptase, it inhibits RNA-dependent DNA synthesis and blocks viral replication. Dapivirine demonstrates broad-spectrum activity against diverse HIV-1 isolates, including various NNRTI-resistant strains, effectively suppressing viral infection and propagation in host cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 34 mg/mL (103.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Antimicrob Agents Chemother. 2005;49(5):2152-2152.

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Note: Technical data last updated: Sep 1, 2026.