CAS No. 662164-09-2
Batch:
Purity:99.96
Chemical Structure
Check the
D3-βArr
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 662164-09-2 | |
|---|---|---|
| Molecular Formula |
C20H23N5 |
|
| Molecular Weight (MW) | 333.43 | |
| SMILES | CC(C1=CC=CC=C1)NC2=NC(=NC3=CC=CC=C32)N4CCNCC4 |
D3-βArr (NCGC00379308) is a positive allosteric modulator of the thyrotropin receptor (TSHR). It potentiates thyroid-stimulating hormone (TSH)-induced signaling by selectively enhancing β-arrestin 1 translocation to the active receptor. This allosteric modulation regulates TSHR-mediated intracellular pathways and downstream thyroid follicular cell function, offering a valuable chemical tool for investigating G protein-coupled receptor bias and thyroid receptor regulation. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
67 mg/mL
(200.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 33 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.