Cyromazine SDS/MSDS (Safety Data Sheet)

3.1 Substances
Product name: Cyromazine
CAS Number: 66215-27-8
PubChem CID: 47866
Molecular formula: C6H10N6
Molecular weight: 166.18 g/mol
IUPAC name: 2-N-cyclopropyl-1,3,5-triazine-2,4,6-triamine

3.2 Mixtures
Not applicable (pure substance).

4.1 Description of first aid measures
Inhalation: Move to fresh air. Keep at rest in a position comfortable for breathing. Seek medical attention if symptoms persist.
Skin contact: Wash with plenty of soap and water. Remove contaminated clothing. Seek medical attention if irritation develops.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Seek medical attention.
Ingestion: Rinse mouth. Do NOT induce vomiting unless directed by medical personnel. Seek medical attention.

4.2 Most important symptoms and effects, both acute and delayed
See Section 11 (Toxicological Information).

4.3 Indication of any immediate medical attention and special treatment needed
Treat symptomatically. Contact a poison control center or physician for severe exposure.

5.1 Extinguishing media
Suitable: Water spray, dry chemical, carbon dioxide (CO2), alcohol-resistant foam.
Unsuitable: None known.

5.2 Specific hazards arising from the substance or mixture
Dry chemical, foam or carbon dioxide

5.3 Advice for firefighters
Wear self-contained breathing apparatus (SCBA) and full protective clothing.
Fight fire from upwind. Cool containers with water spray until fire is extinguished.

6.1 Personal precautions, protective equipment and emergency procedures
Wear appropriate personal protective equipment (see Section 8).
Avoid breathing dust/vapor. Ensure adequate ventilation.
Evacuate personnel to safe areas. Keep people away from and upwind of spill.

6.2 Environmental precautions
Prevent product from entering drains, waterways, or soil.
Contain spill with inert absorbent material.

6.3 Methods and materials for containment and cleaning up
For minor spills, leaks, etc., follow all precautions indicated on /the product/ label and clean up immediately. Take special care to avoid contamination of equipment and facilities during cleanup procedures and disposal of wastes. /Technical cyromazine/
SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.
Container Disposal Do not reuse outer container. Dispose of the empty outer foil pouch and outer container In the trash, as long as water-soluble packets are unbroken. /Trigard 75W/
Pesticide: Wastes resulting from the use of this product may be disposed of on site or at an approved waste disposal facility. Container: Completely empty container including any liner by shaking and tapping sides and bottom to loosen clinging particles. Empty residue into equipment, then dispose of any liner in a sanitary landfill, or by incineration, if allowed by state and local authorities. If drum is contaminated and cannot be reused to contain additional cyromazine technical, dispose of in the same manner as the liner. /Technical cyromazine/
AGRICULTURAL USE REQUIREMENTS: Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR part 170. This Standard contains requirements for the protection of agricultural workers on farms, forests, nurseries, and greenhouses, and handlers of agricultural pesticides. It contains requirements for training, decontamination, notification, and emergency assistance. It also contains specific instructions and exceptions pertaining to the statements on this label about personal protective equipment (PPE) and restricted-entry interval. /Trigard 75W/
Causes moderate eye irritation. Harmful if swallowed, absorbed through the skin, or inhaled. Avoid contact with eyes, skin, or clothing. Avoid breathing dust. Wash thoroughly with soap and water after handling and before eating, drinking, chewing gum, or using tobacco. Remove and wash contaminated clothing before reuse. /Trigard 75W/
Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables, use detergent and hot water. Keep and wash PPE separately from other laundry. /Trigard 75W/
Users should: Wash hands before eating, drinking, chewing gum, using tobacco, or using the toilet. Remove clothing immediately if pesticide gets inside. Then wash thoroughly and put on clean clothing. /Trigard 75W/
For more Preventive Measures (Complete) data for CYROMAZINE (7 total), please visit the HSDB record page.

7.1 Precautions for safe handling
Do not contaminate water, food, or feed by storage or disposal practices. Store in a cool, dry place. Do not store this product under wet conditions. /Technical cyromazine/
Store in well-ventilated, secure area out of reach of children and animals.

7.2 Conditions for safe storage, including any incompatibilities
Do not contaminate water, food, or feed by storage or disposal practices. Store in a cool, dry place. Do not store this product under wet conditions. /Technical cyromazine/
Store in well-ventilated, secure area out of reach of children and animals.
Store away from incompatible materials (see Section 10).
[Note: Specific storage temperature not available in public databases. Refer to supplier Certificate of Analysis (COA) for exact storage conditions.]

9.1 Information on basic physical and chemical properties
a) Appearance: Colorless or white solid; [HSDB]
b) Odor: No data available
c) Odor threshold: No data available
d) pH: No data available
e) Melting point/freezing point: 224.9 °C
f) Initial boiling point and boiling range: No data available
g) Flash point: No data available
h) Evaporation rate: No data available
i) Flammability (solid, gas): No data available
j) Upper/lower flammability or explosive limits: No data available
k) Vapor pressure: 3.36X10-9 mm Hg at 25 °C
l) Vapor density: No data available
m) Relative density: 1.35 g/cu cm (20 °C)
n) Water solubility: All in g/kg, 20 °C: In methanol 22, isopropanol, 2.5, acetone, 1.7, n-octanol 1.2, dichloromethane 0.25, toluene, 0.015, hexane 0.0002
o) Partition coefficient: n-octanol/water: Log P (n-octanol/water): -0.2
p) Auto-ignition temperature: No data available
q) Decomposition temperature: No data available
r) Viscosity: No data available
s) Explosive properties: No data available
t) Oxidizing properties: No data available

9.2 Other information
Topological Polar Surface Area (TPSA): 103 Ų
Complexity: 148

11.1 Information on toxicological effects
Acute toxicity:
Oral Acute Reference Dose (RfDoa)(mg/kg-day): 0.83
Oral Acute Reference Dose Reference: OPP
Acute or One Day PAD (RfD) [mg/kg/day]: 0.83
Acute or One Day HHBPs [ppb]: 5500
Acute HHBP Sensitive Lifestage/Population: Children
Skin corrosion/irritation:
Causes skin irritation (H315).
Serious eye damage/eye irritation:
Causes serious eye irritation (H319).
Respiratory or skin sensitization:
No data available.
Germ cell mutagenicity:
No data available.
Carcinogenicity:
No data available.
Reproductive toxicity:
No data available.
Specific target organ toxicity (single exposure):
No data available.
Specific target organ toxicity (repeated exposure):
No data available.
Aspiration hazard:
No data available.

11.2 Additional information
Carcinogen classification:
No indication of carcinogenicity to humans (not listed by IARC).
Data source: Hazardous Substances Data Bank (HSDB) via PubChem.

12.1 Toxicity
LD50; Species: Anas platyrhynchos (Mallard duck) oral >2510 mg/kg for 14 days
LC50; Species: Anas platyrhynchos (Mallard duck) dietary >5620 ppm for 8 days
LD50; Species: Colinus virginianus (Northern bobwhite) oral 1785 mg/kg for 14 days (95% confidence interval: 1444-2206 mg/kg)
LC50; Species: Colinus virginianus (Northern bobwhite) dietary >5620 ppm for 8 days
For more Ecotoxicity Values (Complete) data for CYROMAZINE (9 total), please visit the HSDB record page.
/BIRDS and MAMMALS/ Acute oral and dietary avian toxicity studies suggest that cyromazine is no more than slightly toxic to birds. Chronic toxicity effects on birds have been domonstrated with two species. Cyromazine significantly reduced the number of normal mallard duck hatchlings at 300 ppm (NOAEC = 75 ppm). In another study, there may have been a slight treatment related increase in the number of male bobwhite quail that exhibited regressing testes at 300 ppm (NOAEC = 75 ppm).
/AQUATIC SPECIES/ Cyromazine has been shown to be practically non-toxic to freshwater fish (e.e., rainbow trout, bluegill sunfish, channel catfish) and freshwater invertebrated (i.e., water flea) on an acute basis. Chronic toxicity studies are also available for freshwater animals. Cyromazine significantly reduced fathead minnow length and weight at 36 mg/L (NOAEC - 14 mg/L) in a fish early life stage toxicity test. A freshwater invertebrate lifecycle test concluded that cyromazine significantly affected daphnid growth and reproduction a

12.2 Persistence and degradability
No data available.

12.3 Bioaccumulative potential
Log P (n-octanol/water): -0.2
Low potential for bioaccumulation (Log P < 3).

12.4 Mobility in soil
No data available.

12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available.

12.6 Other adverse effects
This substance is classified as hazardous to the aquatic environment.

13.1 Waste treatment methods
Waste Treatment Methods: Waste material must be disposed of in accordance with national and local regulations. Leave chemicals in original containers and do not mix with other waste. Handle uncleaned containers in the same manner as the product itself.

14.1 UN number
Not regulated as dangerous goods (research quantities typically exempt).

14.2 UN proper shipping name
Not subject to transport regulations (small quantities for research use).

14.3 Transport hazard class(es)
Not classified as dangerous goods for transport (research quantities).

14.4 Packing group
Not applicable (not regulated as dangerous goods in typical research quantities).

14.5 Environmental hazards
Marine pollutant: Yes (classified as environmentally hazardous per GHS).

14.6 Special precautions for user
Transport in original packaging. Ensure containers are tightly sealed.
For bulk or commercial quantities, consult applicable transport regulations (DOT, IATA, IMDG).

14.7 Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable.

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
US EPA / TSCA: Subject to EPA TSCA regulations
EU ECHA / REACH: Registered (REACH Active)

SARA 302 Components:
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313 Components:
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards:
Acute (short-term) health hazard
Environmental hazard

Massachusetts Right To Know Components:
This material contains components subject to the Massachusetts Right to Know Act. See Section 2 for hazard classification.
Pennsylvania Right To Know Components:
This material contains components subject to the Pennsylvania Right to Know Act. See Section 2 for hazard classification.
New Jersey Right To Know Components:
This material contains components subject to the New Jersey Right to Know Act. See Section 2 for hazard classification.

California Prop. 65 Components:
This product does not contain any chemicals known to the State of California to cause cancer, birth defects, or any other reproductive harm.

Other regulatory listings:
- EFSA Legal Basis: Commission Regulation (EC) No 1490/2002
- Safe Drinking Water Act: Cyromazine is listed in the dataset of EPA Human Health Benchmarks for Pesticides under the Safe Drinking Water Act (40 eCFR 141)
- Status Regulation (EC): 2009/77/EC, Reg. (EU) 2022/801, Reg. (EU) No 540/2011
- FIFRA Requirements: Tolerances are established for residues of the insecticide cyromazine (N-cyclopropyl-1,3,5-triazine-2,4,6-triamine) in or on the following raw agricultural commodities: [Table#6103]
The additive cyromazine (N-cyclopropyl-1,3,5-triazine-2,4,6-triamine) may be safely used in accordance with the follow

15.2 Chemical safety assessment
A chemical safety assessment has not been carried out for this substance.
For research-use-only compounds, no CSA is required under REACH Annex I.

Revision Date: 2026/09/09
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.