CAS No. 427-51-0

Batch: Purity:99.87
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Cyproterone Acetate Chemical Structure
Chemical Structure
Check the Cyproterone Acetate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(1S,2S,3S,5R,11R,12S,15R,16S)-15-acetyl-9-chloro-2,16-dimethyl-6-oxo-15-pentacyclo[9.7.0.02,8.03,5.012,16]octadeca-7,9-dienyl] acetate
CAS Number 427-51-0
Molecular Formula

C24H29ClO4
Molecular Weight (MW) 416.94
SMILES CC(=O)C1(CCC2C1(CCC3C2C=C(C4=CC(=O)C5CC5C34C)Cl)C)OC(=O)C
InChIKey UWFYSQMTEOIJJG-FDTZYFLXSA-N

Ordering Information

Biological Activity

Cyproterone acetate is a synthetic androgen receptor (AR) antagonist that also acts as a weak progesterone receptor agonist with pro-gestational and glucocorticoid activities. By competing with endogenous androgens for binding to AR, it blocks androgen-mediated transcriptional activation and downregulates downstream target gene expression. Consequently, this inhibition suppresses androgen-dependent cell proliferation and retards tumor growth in prostate cancer models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 83 mg/mL (199.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 20 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.