Cyclosporin A is a potent, immunosuppressive calcineurin and mPTP inhibitor. It affects Calcineurin/NFAT signaling by binding to cyclophilin A to inhibit calcineurin and blocking mPTP opening, effectively inhibiting T cell activation, apoptosis, and viral replication.
Cyclosporin A IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Cyclosporin A Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.