CAS No. 152-53-4

Batch: Purity:99.94
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Cycloguanil hydrochloride Chemical Structure
Chemical Structure
Check the Cycloguanil hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 152-53-4
Molecular Formula

C11H14ClN5.ClH
Molecular Weight (MW) 288.18
SMILES CC1(N=C(N=C(N1C2=CC=C(C=C2)Cl)N)N)C.Cl

Biological Activity

Cycloguanil hydrochloride is an active metabolite of proguanil that acts as a potent inhibitor of dihydrofolate reductase. By targeting malarial dihydrofolate reductase, it disrupts the folate metabolic pathway and inhibits nucleic acid synthesis. This blockade impairs DNA replication in Plasmodium parasites, effectively acting on schizonts in erythrocytes and hepatocytes to suppress parasite growth and survival. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 58 mg/mL (201.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 15 mg/mL
Ethanol 15 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Foote SJ, et al. Nature. 1990;345(6272):255-8.

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Note: Technical data last updated: Sep 1, 2026.