CX-5461 (Pidnarulex) Solubility in DMSO

Size	Price	Qty
5mg	USD 270
50mg	USD 970

In Vitro Solubility

Batch:

All in vitro solubility values are batch-tested experimental data (non-literature values).

Solvent	Solubility & Note
DMSO	Insoluble (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water	Insoluble
Ethanol	Insoluble
DMSO	3 mg/mL (5.84 mM) (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water	Insoluble
Ethanol	Insoluble
DMSO	Insoluble (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water	Insoluble
Ethanol	Insoluble
DMSO	2 mg/mL (3.89 mM) (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water	Insoluble
Ethanol	Insoluble
DMF	2 mg/mL
DMSO	Insoluble (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water	Insoluble

FAQ

Q: Why does a DMSO stock precipitate in media/saline?

A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.

How to fix it?

Preheat media/saline to 37°C.
Mix rapidly (pipette/vortex) upon addition.
For complex mixes, always add the aqueous phase last.
Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Check the CX-5461 (Pidnarulex) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Aliquotting Service

Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.

Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.

Formulation for Animal Experiments

Batch:

Administration Route	Formulation Type	Formulation Details	Solubility	Preparation Method
Oral Administration	Homogeneous suspensionCMC-NA	CMC-NA	≥5mg/mL	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Injection	Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.150mg/mL (0.29mM)	Taking the 1 mL working solution as an example, add 50 μL of 3 mg/ml clarified DMSO stock solution to 400 μL PEG300, mix evenly to clarify it; add 50 μL Tween80 to the above system, mix evenly to clarify it; then continue to add 500 μL ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Injection	Clear solution	5% DMSO 1 95% corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.150mg/mL (0.29mM)	Taking the 1 mL working solution as an example, add 50 μL of 3 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Injection	Clear solution	5%DMF 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	2.000mg/mL (3.89mM)	Taking the 1 mL working solution as an example, add 50 μL 40 mg/ml clarified DMF stock solution to 400 μL PEG300, mix evenly to clarify it; add 50 μL Tween80 to the above system, mix evenly to clarify it; then continue to add 500 μL ddH2O to adjust the volume to 1 mL. . The mixed solution should be used immediately for optimal results.
Oral Administration	Homogeneous suspensionCMC-NA	CMC-NA	≥5mg/mL	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Injection	Clear solution	5%DMF 1 95%Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	2.000mg/mL (3.89mM)	Taking the 1 mL working solution as an example, add 50 μL of 40 mg/ml clarified DMF stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Injection	Clear solution	5%DMF 1 95%Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	2.000mg/mL (3.89mM)	Taking the 1 mL working solution as an example, add 50 μL of 40 mg/ml clarified DMF stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

Recommended and Maximum Dosing Volumes for Animal Experiments

Other Animals:

🐁 In Vivo Formulation Calculator

Dosage: mg/kg

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Avg Wt: g

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Vol/Animal: μL

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Animals:

% DMSO

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% PEG300

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% Tween 80

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% ddH₂O

CX-5461 (Pidnarulex) Solubility

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In Vitro Solubility

Aliquotting Service

Formulation for Animal Experiments

Recommended and Maximum Dosing Volumes for Animal Experiments

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