CX-5461 (Pidnarulex) is a first-in-class, selective RNA polymerase I inhibitor. It affects ATM/ATR and p53 signaling pathways by inhibiting rDNA transcription and inducing DNA damage, effectively suppressing cancer cell proliferation and promoting apoptosis.
CX-5461 (Pidnarulex) IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for CX-5461 (Pidnarulex) Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.