CAS No. 199986-75-9

Batch: Purity:99.91
Check CoA
CVT-313 Chemical Structure
Chemical Structure
Check the CVT-313 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[2-hydroxyethyl-[6-[(4-methoxyphenyl)methylamino]-9-propan-2-ylpurin-2-yl]amino]ethanol
CAS Number 199986-75-9
Molecular Formula

C20H28N6O3
Molecular Weight (MW) 400.47
SMILES CC(C)N1C=NC2=C(N=C(N=C21)N(CCO)CCO)NCC3=CC=C(C=C3)OC
InChIKey NQVIIUBWMBHLOZ-UHFFFAOYSA-N

Biological Activity

CVT-313 is a potent, ATP-competitive inhibitor of cyclin-dependent kinase 2 (CDK2) with an IC50 of 0.5 µM. By selectively inhibiting CDK2 activity, CVT-313 blocks cell cycle progression at the G1/S phase transition and suppresses hyperphosphorylation of retinoblastoma protein. Consequently, it significantly inhibits vascular smooth muscle cell proliferation and suppresses neointimal hyperplasia without affecting nonrelated serine/threonine kinases. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 80 mg/mL (199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 80 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Brooks EE, et al. J Biol Chem. 1997;272(46):29207-11.

Jump to

Note: Technical data last updated: Sep 1, 2026.