CAS No. 1005334-57-5
Batch:
Purity:99.73
Chemical Structure
Check the
CVT-10216
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 3-[[3-[4-(methanesulfonamido)phenyl]-4-oxochromen-7-yl]oxymethyl]benzoic acid | |
|---|---|---|
| CAS Number | 1005334-57-5 | |
| Molecular Formula |
C24H19NO7S |
|
| Molecular Weight (MW) | 465.48 | |
| SMILES | C[S](=O)(=O)NC1=CC=C(C=C1)C2=COC3=C(C=CC(=C3)OCC4=CC(=CC=C4)C(O)=O)C2=O | |
| InChIKey | YYOOFJZTRCPVFD-UHFFFAOYSA-N |
Biological Activity
CVT-10216 is a highly selective, reversible inhibitor of aldehyde dehydrogenase-2 (ALDH-2) with an ICof. By inhibiting ALDH-2 enzymatic activity, CVT-10216 disrupts aldehyde metabolism, leading to elevated systemic acetaldehyde levels following ethanol exposure. Downstream, this inhibition attenuates ethanol-stimulated dopamine release in the nucleus accumbens, thereby suppressing heavy alcohol intake and alcohol seeking, as well as withdrawal-associated anxiety. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
93 mg/mL
(199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.