CAS No. 39777-61-2

Batch: Purity:99.74
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Curcumin analog C1 Chemical Structure
Chemical Structure
Check the Curcumin analog C1 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one
CAS Number 39777-61-2
Molecular Formula

C19H18O3
Molecular Weight (MW) 294.34
SMILES COC1=CC=CC=C1C=CC(=O)C=CC2=CC=CC=C2OC
InChIKey RCZMPCUUTSDNAJ-PHEQNACWSA-N

Biological Activity

Curcumin analog C1 is a potent synthetic activator of transcription factor EB (TFEB). It directly binds TFEB and promotes its nuclear translocation, thereby stimulating lysosomal biogenesis and enhancing the autophagy-lysosome pathway. Consequently, this downstream activation promotes the clearance of pathogenic protein aggregates, including amyloid-beta and tau, highlighting its potential in neurodegenerative disease research such as Alzheimer's disease. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 30 mg/mL (101.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 2 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Song WH, et al. Autophagy. 2016;12(12):2510-2511.

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Note: Technical data last updated: Sep 1, 2026.