CAS No. 19431-84-6

Batch: Purity:99.89
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Curcumenol Chemical Structure
Chemical Structure
Check the Curcumenol product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1S,2S,5S,8R)-2,6-dimethyl-9-propan-2-ylidene-11-oxatricyclo[6.2.1.01,5]undec-6-en-8-ol
CAS Number 19431-84-6
Molecular Formula

C15H22O2
Molecular Weight (MW) 234.33
SMILES CC1CCC2C13CC(=C(C)C)C(O3)(C=C2C)O
InChIKey ISFMXVMWEWLJGJ-NZBPQXDJSA-N

Biological Activity

Curcumenol is a natural sesquiterpene that acts as an inhibitor of the NF-κB signaling pathway. It suppresses NF-κB activation by blocking IκBα phosphorylation and degradation, thereby preventing the nuclear translocation of the NF-κB p65 subunit. Downstream, this inhibition attenuates the expression of pro-inflammatory mediators, promoting neuroprotective, anti-inflammatory, hepatoprotective, and anti-tumor phenotypes in cellular models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 46 mg/mL (196.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.