CAS No. 2165340-32-7
Batch:
Purity:99.93
Chemical Structure
Check the
CU-CPT9a
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-(7-methoxyquinolin-4-yl)-2-methylphenol | |
|---|---|---|
| CAS Number | 2165340-32-7 | |
| Molecular Formula |
C17H15NO2 |
|
| Molecular Weight (MW) | 265.31 | |
| SMILES | COC1=CC2=C(C=C1)C(=CC=N2)C3=CC(=C(O)C=C3)C | |
| InChIKey | HNYBTVKYLVLWCB-UHFFFAOYSA-N |
Biological Activity
CU-CPT9a is a potent and specific Toll-like receptor 8 (TLR8) antagonist with an IC50 of 0.5 nM. By binding to the TLR8 dimer interface, CU-CPT9a inhibits agonist-induced conformational changes, effectively blocking downstream NF-kB signaling pathways. Consequently, this targeted inhibition suppresses TLR8-mediated proinflammatory cytokine production, including TNF-α and IL-1β, in human primary immune cells. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
53 mg/mL
(199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.