CAS No. 125079-83-6
Batch:
Purity:99.98
Chemical Structure
Check the
CU-CPT-8m
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 125079-83-6 | |
|---|---|---|
| Molecular Formula |
C14H12N4O |
|
| Molecular Weight (MW) | 252.27 | |
| SMILES | CC1=CC(=CC=C1)C2=CC=NC3=C(C=N[N]23)C(N)=O |
CU-CPT-8m is a specific antagonist of Toll-like receptor 8 (TLR8). By targeted binding to TLR8, it inhibits receptor dimer activation and suppresses downstream NF-κB signaling pathways. This inhibition results in the downstream reduction of pro-inflammatory cytokine production, including TNF-α and IL-6, attenuating immune cell activation and inflammatory responses in cellular models. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
6 mg/mL
(23.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.