CAS No. 1380087-89-7

Batch: Purity:99.04
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Pelabresib (CPI-0610) Chemical Structure
Chemical Structure
Check the Pelabresib (CPI-0610) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[(4S)-6-(4-chlorophenyl)-1-methyl-4H-[1,2]oxazolo[5,4-d][2]benzazepin-4-yl]acetamide
CAS Number 1380087-89-7
Molecular Formula

C20H16ClN3O2
Molecular Weight (MW) 365.81
SMILES CC1=NOC2=C1C3=CC=CC=C3C(=NC2CC(=O)N)C4=CC=C(C=C4)Cl
InChIKey GCWIQUVXWZWCLE-INIZCTEOSA-N

Ordering Information

Biological Activity

Pelabresib (CPI-0610) is a potent and selective benzoisoxazoloazepine inhibitor of BET bromodomains, including BRD4. By selectively binding to BET bromodomains, pelabresib disrupts the recruitment of bromodomain proteins to chromatin, thereby suppressing downstream gene expression, including MYC and NSD3 target genes. This inhibition disrupts transcriptional programs involved in oncogenesis and cellular proliferation, leading to suppressed tumor cell growth and induced apoptosis in hematological tumor models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 73 mg/mL (199.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 73 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.