CP-673451 is a selective PDGFR inhibitor. It affects PDGF, Akt, and MEK signaling pathways, and by blocking PDGFR phosphorylation and activating cofilin, it inhibits tumor cell proliferation and migration, and promotes apoptosis.
CP-673451 IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for CP-673451 Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.