CAS No. 343787-29-1
Batch:
Purity:99.66
Chemical Structure
Check the
CP-673451
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[2-[5-(2-methoxyethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-amine | |
|---|---|---|
| CAS Number | 343787-29-1 | |
| Molecular Formula |
C24H27N5O2 |
|
| Molecular Weight (MW) | 417.5 | |
| SMILES | COCCOC1=CC2=C(C=C1)N(C=N2)C3=NC4=C(C=CC=C4N5CCC(CC5)N)C=C3 | |
| InChIKey | DEEOXSOLTLIWMG-UHFFFAOYSA-N |
CP-673451 is a selective receptor tyrosine kinase inhibitor targeting PDGFRα (IC50 = 10 nM) and PDGFRβ (IC50 = 1 nM). By inhibiting PDGF-BB-stimulated receptor autophosphorylation, it suppresses downstream signal transduction. This blockade leads to marked antiangiogenic and antitumor effects, significantly inhibiting PDGF-driven neovascularization and tumor xenograft growth while displaying over 450-fold selectivity over other angiogenic receptors. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
6 mg/mL
(14.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| Ethanol | 41 mg/mL |
| DMSO |
25 mg/mL
(59.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| DMSO |
83 mg/mL
(198.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 24 mg/mL |
| Water | Insoluble |
| DMSO |
132 mg/mL
(316.16 mM)
; Warmed with 60°C water bath
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 60 mg/mL |
| Water | Insoluble |
| Ethanol | 83 mg/mL |
| DMSO |
28 mg/mL
(67.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- CP-673451 Mechanism of Action: PDGFR Inhibition in Cancer Cell Research
- CP-673451 Working Concentration | Cell Culture | Treatment
- CP-673451 Solubility in DMSO
- CP-673451 Stock Solution
- CP-673451 Storage
- CP-673451 Stability
- CP-673451 Combination Database
- CP-673451 Molecular Weight
- CP-673451 SMILES
- CP-673451 Chemical Structure (2D and 3D)
- CP-673451 IC50 for Cell-based and Cell-free Assays
- CP-673451 Tocris (5993)? Try a better option.
- CP-673451 Cayman (19170)? Try a better option.
- CP-673451 MedChemExpress (HY-12050)? Try a better option.
- CP-673451 Sigma (SML3368)? Try a better option.
- CP-673451 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.