CAS No. 1433286-70-4
| IUPAC Name | 3-(3-aminopropoxy)-N-[2-[3-[(4-chloro-2-hydroxyphenyl)carbamoyl]naphthalen-2-yl]oxyethyl]naphthalene-2-carboxamide;hydrochloride | |
|---|---|---|
| CAS Number | 1433286-70-4 | |
| Molecular Formula |
C33H31Cl2N3O5 |
|
| Molecular Weight (MW) | 620.52 | |
| SMILES | C1=CC=C2C=C(C(=CC2=C1)C(=O)NCCOC3=CC4=CC=CC=C4C=C3C(=O)NC5=C(C=C(C=C5)Cl)O)OCCCN.Cl | |
| InChIKey | LELLCPHHYHLWBH-UHFFFAOYSA-N |
Compound 3i (666-15) is a potent and selective inhibitor of CREB-mediated gene transcription with an IC50 of. It disrupts CREB-dependent transcriptional activation, thereby downregulating downstream gene expression required for tumor cell survival and proliferation. Consequently, 666-15 potently inhibits cancer cell growth while exhibiting minimal toxicity toward normal cells, demonstrating significant antiproliferative activity across multiple cancer models.
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(161.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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