Cobimetinib (GDC-0973): Selectivity & Specificity

Cobimetinib (GDC-0973) is a potent inhibitor of MEK1 (0.95 nM), MEK2 (199 nM). Cobimetinib (GDC-0973) exhibits the greatest inhibitory potency toward MEK1 (IC50 = 0.95 nM).