CAS No. 2030-63-9
| CAS Number | 2030-63-9 | |
|---|---|---|
| Molecular Formula |
C27H22Cl2N4 |
|
| Molecular Weight (MW) | 473.4 | |
| SMILES | CC(C)N=C1C=C2C(=NC3=CC=CC=C3N2C4=CC=C(C=C4)Cl)C=C1NC5=CC=C(C=C5)Cl |
Clofazimine is a riminophenazine dye possessing antimicrobial and anti-inflammatory activities. It functions in part by intercalating into bacterial DNA and stimulating cellular phospholipase A2 activity, leading to membrane dysfunction and generation of antimicrobial reactive oxygen species. Additionally, clofazimine suppresses Wnt/beta-catenin signaling pathway activation, inhibiting cell proliferation and downstream transcriptional programs in target cells. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
5 mg/mL
(10.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
5 mg/mL
(10.56 mM)
; Warmed with 60°C water bath
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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