CAS No. 1784751-20-7

Batch: Purity:99.48
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CK1-IN-1 Chemical Structure
Chemical Structure
Check the CK1-IN-1 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[2-(1-fluoronaphthalen-2-yl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyridine
CAS Number 1784751-20-7
Molecular Formula

C24H15F2N3
Molecular Weight (MW) 383.39
SMILES C1=CC=C2C(=C1)C=CC(=C2F)C3=NC(=C(N3)C4=CC=NC=C4)C5=CC=C(C=C5)F
InChIKey PUQAFIILJICJRR-UHFFFAOYSA-N

Biological Activity

CK1-IN-1 is a potent inhibitor targeting casein kinase 1 delta (CK1δ), casein kinase 1 epsilon (CK1ε), and p38α MAPK. Inhibition of CK1δ and CK1ε disrupts critical downstream signaling cascades, including the Wnt/β-catenin pathway and circadian clock dynamics. Consequently, suppressing these kinase activities impacts fundamental cellular functions such as cell cycle progression, apoptosis, and cellular proliferation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 77 mg/mL (200.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Cheong JK, et al. Int J Biochem Cell Biol. 2011;43(4):465-9.

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Note: Technical data last updated: Sep 1, 2026.