Clinical Trials

Numerous clinical trials evaluate the therapeutic utility of citalopram and related formulations across a broad spectrum of conditions, including major depressive disorder, functional chest pain, obsessive-compulsive disorder, Alzheimer's disease, acute coronary syndrome, and ischemic stroke. Spanning phase 1 through phase 4, these studies are supported by academic institutions and industrial sponsors. Recruitment statuses across the portfolio vary, encompassing active, completed, terminated, and withdrawn protocols.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06433635 ACTIVE_NOT_RECRUITING
Bipolar I Disorder; Depression
Massachusetts General Hospital
 2024-10-01 PHASE4
NCT05901571 NOT_YET_RECRUITING
Depressive Disorder, Major
Shanghai 7th People's Hospital
 2026-11
NCT06949644 RECRUITING
Delayed Sleep-Wake Phase Disorder
Northwestern University
 2025-09-01
NCT05017311 RECRUITING
Major Depressive Disorder
Nova Scotia Health Authority
 2023-01-20 PHASE4
NCT05973786 RECRUITING
Bipolar Depression
Dr. Inge Winter
 2025-02-11 PHASE3
NCT05603104 RECRUITING
Schizophrenia and Related Disorders; Major Depressive Disorder; Bipolar Depression
Dr. Inge Winter
 2025-04-27 PHASE3
NCT04846829 ACTIVE_NOT_RECRUITING
Major Depressive Disorder
University of California, Los Angeles
 2017-04-24 EARLY_PHASE1
NCT04336228 ACTIVE_NOT_RECRUITING
Obsessive-Compulsive Disorder/High Compulsive Individuals; Healthy Individuals
Rigshospitalet, Denmark
 2020-04-01 PHASE4
NCT07478796 RECRUITING
Depression - Major Depressive Disorder; Depressive Episodes
Poznan University of Medical Sciences
 2025-04-03 PHASE4
NCT06210321 NOT_YET_RECRUITING
Pharmacogenetic Testing
Chantal Csajka
 2025-08-15
NCT07139834 RECRUITING
Major Depressive Disorder (MDD)
Jeffrey Miller
 2026-06-01 PHASE1
NCT03728673 RECRUITING
Glioma of Brain; Glioma
University of Nebraska
 2019-03-06 PHASE2
NCT03843463 RECRUITING
Aphasia; Stroke
Johns Hopkins University
 2021-07-18 PHASE2
NCT07645807 NOT_YET_RECRUITING
Adjunct in the Treatment of Depressive Disorder
Sichuan Credit Pharmaceutical Co., Ltd.
 2026-06-11
NCT07025590 RECRUITING
Cardiovascular Diseases (CVD); Depression Anxiety Disorder
Guangdong Provincial People's Hospital
 2025-04-22
NCT05480150 RECRUITING
Major Depressive Disorder; Bipolar Disorder, Mixed; Affective; Disorder, Organic
First Affiliated Hospital of Zhejiang University
 2021-11-01
NCT07480525 RECRUITING
Depression - Major Depressive Disorder
Peking University
 2026-03-20
NCT06740188 RECRUITING
Depressed Insomniac Co-morbid Patients
Tongji University
 2025-01-01 PHASE4
NCT05004987 RECRUITING
Alzheimer Disease; Major Depressive Disorder
NYU Langone Health
 2022-02-04 PHASE4
NCT05737511 NOT_YET_RECRUITING
Panic Disorder
Sultan Qaboos University
 2023-12-30 PHASE4
NCT07331987 RECRUITING
Anxiety Depression
Moon (Guangzhou) Biotechnology Co., Ltd.
 2026-06-15
NCT06826326 ENROLLING_BY_INVITATION
Autism Spectrum Disorder
Kathryn Unruh
 2025-04-28 PHASE2
NCT06705478 SUSPENDED
Major Depressive Disorder; Mild Neurocognitive Disorder; HIV
National Institute of Allergy and Infectious Diseases (NIAID)
 2026-05-17 PHASE2
NCT06796946 NOT_YET_RECRUITING
Deprescription; Antidepressants
University of Huelva
 2026-06 EARLY_PHASE1
NCT06675851 RECRUITING
Major Depressive Disorder (MDD)
Medical University of Vienna
 2022-12-01 PHASE4
NCT06412315 RECRUITING
Emotional Processing; Cognition; Mood Disorders; Depressive Disorder; Depression
University of Oxford
 2025-02-13
NCT05866575 RECRUITING
Major Depressive Disorder
Centre Hospitalier St Anne
 2023-09-12
NCT06828887 RECRUITING
MDD
Vigonvita Life Sciences
 2025-04-03 PHASE2
NCT04623099 RECRUITING
Anxiety
University of Cincinnati
 2021-03-08 PHASE4
NCT06692361 RECRUITING
Major Depressive Disorder (MDD); Depression - Major Depressive Disorder
Gang Wang
 2025-01-01
NCT06937476 ACTIVE_NOT_RECRUITING
Major Depressive Disorder (MDD); Rumination
Central South University
 2025-05-08
NCT07590609 COMPLETED
Liver-Stagnation and Spleen-Deficiency; Severe Major Depression Disorder
Peking University Sixth Hospital
 2023-05-23 PHASE4
NCT05818735 UNKNOWN
Depression
Shanghai Municipal Hospital of Traditional Chinese Medicine
 2023-12-01
NCT06965569 COMPLETED
Treatment Resistant Depression
Alar Pharmaceuticals Inc.
 2025-04-21 PHASE1
NCT04975724 UNKNOWN
Major Depressive Disorder
Fidia Farmaceutici s.p.a.
 2019-04-18 PHASE4
NCT06696482 NOT_YET_RECRUITING
Effort Based Decision Making; Prosocial Behavior; Apathy
University of Oxford
 2025-01 PHASE1; PHASE2
NCT04245748 UNKNOWN
Anxious Depression; Depression
University of Cincinnati
 2020-03-01 PHASE4
NCT04245436 UNKNOWN
Anxiety; Depressive Symptoms
University of Cincinnati
 2020-01-01 PHASE4
NCT05536414 COMPLETED
Major Depressive Disorder
Otsuka Pharmaceutical Development & Commercialization, Inc.
 2022-09-12 PHASE2
NCT07628153 COMPLETED
Anxiety Disorders
I.M. Sechenov First Moscow State Medical University
 2022-07-11 PHASE4
NCT07113145 COMPLETED
Premature (Early) Ejaculation
Beni-Suef University
 2024-06-01 PHASE4
NCT05945342 UNKNOWN
Depressive Disorder; Adolescent
First Affiliated Hospital of Zhejiang University
 2023-01-31
NCT04156425 UNKNOWN
Major Depressive Disorder
Shanghai Mental Health Center
 2020-07-01
NCT04410341 WITHDRAWN
Major Depressive Disorder
Sadat City University
 2020-05-01 PHASE1; PHASE2
NCT05389046 UNKNOWN
Outpatients / Inpatients With Depression
Peking University
 2022-08-15
NCT06680531 COMPLETED
Insomnia; Central Nervous System
Shanghai Haiyan Pharmaceutical Technology Co., Ltd.
 2024-08-31 PHASE1
NCT06192589 COMPLETED
Cannabidiol; Drug Induced Liver Injury; Drug Interaction
Food and Drug Administration (FDA)
 2024-02-08 PHASE1
NCT05041582 UNKNOWN
Stroke; Motor
Chih-Wei Tang
 2021-09-01 PHASE3
NCT06500624 COMPLETED
Depression
Riphah International University
 2024-06-03
NCT05957094 UNKNOWN
Depression; Serotonin Deficiency
University of British Columbia
 2023-08
NCT04301271 COMPLETED
Depressive Disorder, Major; Obesity
Charite University, Berlin, Germany
 2020-08-13 PHASE2
NCT03108846 ACTIVE_NOT_RECRUITING
Dementia
JHSPH Center for Clinical Trials
 2018-01-03 PHASE3
NCT05627154 COMPLETED
Low Mood; Depression; Anxiety
University of Oxford
 2021-05-28
NCT06025474 UNKNOWN
Burning Mouth Syndrome
Federico II University
 2023-01-01 PHASE3
NCT05470465 COMPLETED
Hypercapnia; Ventilatory Depression
Food and Drug Administration (FDA)
 2022-09-01 PHASE1
NCT05289830 TERMINATED
Pancreatic Ductal Adenocarcinoma; Periampullary Cancer
Case Comprehensive Cancer Center
 2022-08-05 PHASE2
NCT03128021 COMPLETED
Major Depressive Disorder
Howard Aizenstein
 2017-05-24 PHASE4
NCT04388202 WITHDRAWN
Major Depressive Disorder
Alto Neuroscience
 2020-10-15 PHASE4
NCT05588102 COMPLETED
Geriatric Depression; Cognitive Impairment
Capital Medical University
 2021-05-18
NCT03527043 TERMINATED
Sperm DNA Fragmentation; Infertility, Male
Weill Medical College of Cornell University
 2017-10-01 PHASE2
NCT05480878 COMPLETED
Rheumatoid Arthritis
Tanta University
 2022-12-02 PHASE3
NCT03779789 COMPLETED
Major Depressive Disorder
Azienda Ospedaliera Universitaria Integrata Verona
 2019-02-01 PHASE4
NCT04145076 UNKNOWN
Autism Spectrum Disorder
King's College London
 2014-12-15
NCT03652870 COMPLETED
Depression; Parkinson Disease
University College, London
 2021-03-05 PHASE3
NCT03623711 UNKNOWN
Major Depressive Disorder; Depression, Unipolar
Yuqi Cheng
 2018-08-01 EARLY_PHASE1
NCT04162522 COMPLETED
Major Depressive Disorder
University Health Network, Toronto
 2019-12-23 PHASE3
NCT05145270 UNKNOWN
Major Depressive Disorder
Shanghai Mental Health Center
 2019-11-30 PHASE4
NCT04766229 COMPLETED
Menopause; Cancer; Insomnia
University College Dublin
 2021-06-21 PHASE2
NCT06325605 COMPLETED
Adolescent Depression
Zhen-Hong Hu
 2022-03-01
NCT04239339 COMPLETED
Healthy
Rigshospitalet, Denmark
 2020-04-28 PHASE4
NCT04352101 COMPLETED
Major Depression
Emory University
 2020-09-23 PHASE4
NCT02389465 COMPLETED
Depression; Inflammation
University of Pennsylvania
 2014-08 PHASE4
NCT07074652 COMPLETED
Anxiety
UCLH/UCL Joint Research Office
 2017-12-01
NCT02532660 TERMINATED
Depression
Laboratório Catarinense SA
 2018-07-02 PHASE3
NCT07077291 COMPLETED
Treatment-resistant Depression (TRD)
Yun Zhang
 2020-02-01
NCT05063604 TERMINATED
Breast Cancer; Major Depressive Episode
Hospital Universitari de Bellvitge
 2022-05-10 PHASE2
NCT05735756 TERMINATED
Functional Chest Pain
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
 2022-01-17 PHASE4
NCT02620150 COMPLETED
Depression; HIV; AIDS
University of Pennsylvania
 2017-02-16 PHASE4
NCT03993457 TERMINATED
Depression
University of Texas Southwestern Medical Center
 2019-07-23 PHASE4
NCT05271084 COMPLETED
Major Depressive Disorder
Hawler Medical University
 2021-11-10 PHASE1; PHASE2
NCT04590612 UNKNOWN
Parkinson Disease; Depression
Western University, Canada
 2021-01
NCT03899194 UNKNOWN
Major Depressive Disorder
Shanghai Mental Health Center
 2019-01-01
NCT03148522 UNKNOWN
Diagnosis and Treatment of Depression
Peking University
 2017-06-01
NCT04763135 TERMINATED
Cancer; Neoplasms; Neoplasm Metastasis
Hospices Civils de Lyon
 2021-12-15 PHASE3
NCT03346239 COMPLETED
Social Anxiety Disorder
Tel Aviv University
 2018-07-20
NCT05346445 COMPLETED
Postmenopause; Hot Flashes
Hospital Regional 1o de Octubre
 2021-01-20
NCT03522844 COMPLETED
Anxiety Disorders; Generalized Anxiety Disorder; Panic Disorder; Social Anxiety Disorder; Agoraphobia
Georgetown University
 2018-06-18 PHASE4
NCT04476030 COMPLETED
Depressive Disorder, Major
Biogen
 2020-11-09 PHASE3
NCT03924323 COMPLETED
Anxiety Disorders,Generalized Anxiety Disorder
AbbVie
 2019-05-30 PHASE4
NCT03852160 WITHDRAWN
Depressive Disorder, Treatment-Resistant
Janssen-Cilag International NV
 2019-12-01 PHASE3
NCT03909217 COMPLETED
Mild-to-moderate Depression
The University of Hong Kong
 2019-07-29 PHASE2; PHASE3
NCT03841474 UNKNOWN
Coronary Artery Disease; Depression; Cardiovascular Diseases
Klinički Bolnički Centar Zagreb
 2021-03-01
NCT03321006 COMPLETED
Hearing Loss; Depression
New York State Psychiatric Institute
 2018-05-30 PHASE4
NCT04697693 TERMINATED
Post Traumatic Stress Disorder; Major Depressive Disorder
New York State Psychiatric Institute
 2021-03-03 PHASE4
NCT04777838 UNKNOWN
Muscle Type Temporomandibular Disorders; Myofascial Pain of the Masticatory Muscles
University of Coimbra
 2021-03 PHASE2; PHASE3
NCT03434041 COMPLETED
Depressive Disorder, Treatment-Resistant
Janssen Research & Development, LLC
 2018-05-25 PHASE3
NCT03887624 COMPLETED
Depressive Disorder, Treatment-Resistant
Zhejiang University
 2019-05-21 EARLY_PHASE1
NCT03499171 UNKNOWN
GERD
Universitaire Ziekenhuizen KU Leuven
 2019-05-27 PHASE4
NCT04221256 WITHDRAWN
Stroke, Ischemic
Burke Medical Research Institute
 2020-03-11 PHASE1; PHASE2
NCT04037111 UNKNOWN
Major Depressive Disorder; Rheumatoid Arthritis
Xijing Hospital
 2019-07-23
NCT03912974 COMPLETED
Healthy
University Hospital, Basel, Switzerland
 2019-07-04 PHASE1
NCT04169230 UNKNOWN
Molecular Mechanisms of Pharmacological Action; Depression; Depressive Disorder; Mental Disorder; Antidepressive Agents; Cognition
University of Oxford
 2019-10-11
NCT04161209 UNKNOWN
Depression; Depressive Disorder; Mental Disorder; Antidepressive Agents; Cognition; Stress
University of Oxford
 2019-10-11
NCT02332291 COMPLETED
Major Depressive Disorder
Vanderbilt University Medical Center
 2015-04 PHASE4
NCT04234776 UNKNOWN
Depressive Disorder
University of Sao Paulo
 2018-04-03 PHASE4
NCT03812588 COMPLETED
Major Depressive Disorder
New York State Psychiatric Institute
 2019-01-30 PHASE4
NCT00958633 TERMINATED
Bipolar I Disorder
University of British Columbia
 2010-11 PHASE3
NCT02623205 COMPLETED
Depression
Stony Brook University
 2015-05 PHASE4
NCT03487211 COMPLETED
Fibromyalgia
Shaheed Zulfiqar Ali Bhutto Medical University
 2018-04-09 PHASE2; PHASE3
NCT04097288 COMPLETED
Stress Urinary Incontinence; Fecal Incontinence
University Hospital Bispebjerg and Frederiksberg
 2019-09-17 PHASE1
NCT02711215 UNKNOWN
Major Depressive Disorder
Medical University of Vienna
 2015-05 PHASE4
NCT00693849 UNKNOWN
Major Depressive Disorder
BRC Operations Pty. Ltd.
 2008-09 PHASE4
NCT02473250 COMPLETED
Bipolar Disorder
New York State Psychiatric Institute
 2015-01 PHASE4
NCT02655354 COMPLETED
Posttraumatic Stress Disorder; Depression; Alcohol-Related Disorders; Suicidal Ideation; Substance-Related Disorders; Mild Cognitive Impairment; Quality of Life; Pain; Wounds and Injury; Brain Injuries; Chronic Disease
University of Washington
 2015-10
NCT03274817 TERMINATED
Alzheimer Disease
NYU Langone Health
 2009-06-18 PHASE1
NCT03464383 COMPLETED
Anxiety; Depression; Epilepsy
Wake Forest University Health Sciences
 2018-05-07 PHASE4
NCT02753738 UNKNOWN
Ssri; Neuronal Plasticity
Medical University of Vienna
 2016-08 PHASE4
NCT01728194 COMPLETED
Depression
Weill Medical College of Cornell University
 2012-07 PHASE4
NCT03607331 UNKNOWN
Depression; Depressive Symptom; Depressive Disorder
China Academy of Chinese Medical Sciences
 2018-09-17 EARLY_PHASE1
NCT02869035 COMPLETED
Major Depressive Disorder
Rigshospitalet, Denmark
 2016-08 PHASE1
NCT03907215 COMPLETED
Healthy
Idorsia Pharmaceuticals Ltd.
 2019-04-09 PHASE1
NCT03388164 TERMINATED
Depression
Laureate Institute for Brain Research, Inc.
 2018-01-01 PHASE2
NCT04543123 COMPLETED
Major Depressive Disorder
Jeong-Ho Chae
 2017-11-16 PHASE4
NCT02818751 COMPLETED
Anxiety
University of Cincinnati
 2015-05
NCT03187093 UNKNOWN
Major Depressive Disorder
Oleg Levada
 2016-10 PHASE4
NCT04093960 TERMINATED
Major Depression
Kaohsiung Kai-Suan Psychiatric Hospital
 2016-11-18 PHASE4
NCT01902004 COMPLETED
Mild Cognitive Impairment (MCI); Depression
University of California, Los Angeles
 2013-10 PHASE4
NCT01931202 COMPLETED
Major Depressive Disorder
New York State Psychiatric Institute
 2014-02-19
NCT03899285 COMPLETED
Major Depressive Disorder
Ciusss de L'Est de l'Île de Montréal
 2018-01-08 PHASE2
NCT06212284 COMPLETED
Healthy
University of Sussex
 2018-02-18
NCT03122158 UNKNOWN
Major Depressive Disorder; Anxiety Disorders
Erzurum Regional Training & Research Hospital
 2017-04-08 PHASE4
NCT03323697 UNKNOWN
Depression, Anxiety
Mazra Mental Health Center
 2017-08-28 PHASE1; PHASE2
NCT03547219 COMPLETED
Depression; Adolescent
Seoul National University
 2015-08-05
NCT00550485 COMPLETED
Pharmacokinetics
Max-Planck-Institute of Psychiatry
 2007-10
NCT03282110 UNKNOWN
Depression; Psychoneurotic; Pain
China Academy of Chinese Medical Sciences
 2017-11-30 EARLY_PHASE1
NCT02269540 COMPLETED
Major Depressive Disorder
Centre for Addiction and Mental Health
 2014-10 EARLY_PHASE1
NCT04013464 COMPLETED
Depressive Disorder, Major
Peking University Sixth Hospital
 2016-05-01
NCT03522987 WITHDRAWN
Anxiety; Depression; Epilepsy
Wake Forest University Health Sciences
 2018-05 PHASE4
NCT04776226 COMPLETED
Stroke Recurrence; Cardiovascular Events; Depression
Ege University
 2017-02-11
NCT02417064 COMPLETED
Treatment-resistant Depression
Janssen Research & Development, LLC
 2015-08-10 PHASE3
NCT02493868 COMPLETED
Depressive Disorder, Treatment-Resistant
Janssen Research & Development, LLC
 2015-10-01 PHASE3
NCT03131050 COMPLETED
Major Depressive Disorder
Capital Medical University
 2017-03-15 PHASE4
NCT03010761 TERMINATED
Addiction
China Medical University Hospital
 2016-01-14 PHASE2
NCT01479829 COMPLETED
Bipolar Depression
Loyola University
 2011-03-23 PHASE4
NCT02623231 UNKNOWN
GBM; Depression
Tel-Aviv Sourasky Medical Center
 2015-12 PHASE2; PHASE3
NCT03162185 UNKNOWN
Healthy Controls
Max Planck Institute for Human Cognitive and Brain Sciences
 2017-04-01 PHASE4
NCT02497287 COMPLETED
Treatment-resistant Depression
Janssen Research & Development, LLC
 2015-09-30 PHASE3
NCT05840692 COMPLETED
Polycystic Ovary Syndrome
Odense University Hospital
 2013-08 PHASE4
NCT01657760 COMPLETED
Alcohol Dependence
VA Office of Research and Development
 2014-05-01 PHASE1
NCT02422186 COMPLETED
Depressive Disorder, Treatment-Resistant
Janssen Research & Development, LLC
 2015-08-20 PHASE3
NCT02825342 TERMINATED
Chest Pain Rule Out Myocardial Infarction
Evangelismos Hospital
 2014-03 PHASE4
NCT02374567 TERMINATED
Dementia; Depression; Schizophrenia; Psychosomatic Disorders; Anxiety Disorders
Hannover Medical School
 2015-01 PHASE3
NCT02418585 COMPLETED
Treatment-resistant Depression
Janssen Research & Development, LLC
 2015-08-07 PHASE3
NCT01360866 COMPLETED
Depressive Disorder; Depression; Depressive Disorder, Major; Mood Disorders; Mental Disorders
Otsuka Pharmaceutical Development & Commercialization, Inc.
 2011-10 PHASE3
NCT02386475 COMPLETED
Stroke
Hospital de Granollers
 2015-01 PHASE4
NCT02407821 TERMINATED
End Stage Renal Disease
University Health Network, Toronto
 2015-03 PHASE2
NCT01997580 UNKNOWN
Major Depressive Disorder
Seoul National University Bundang Hospital
 2013-07 PHASE4
NCT02191397 COMPLETED
Depressive Disorder, Major
GlaxoSmithKline
 2015-02-10 PHASE3
NCT01477203 COMPLETED
Major Depressive Disorder (MDD); Anxiety Disorder
Medical University of Vienna
 2011-11 PHASE4
NCT01787240 TERMINATED
Major Depressive Disorder
Massachusetts General Hospital
 2012-11 PHASE4
NCT01535573 COMPLETED
Cocaine Dependence
Joy Schmitz
 2010-12 PHASE2
NCT01894815 COMPLETED
Major Depressive Disorder; Major Depressive Disorder, Recurrent, Unspecified; Major Depressive Disorder, Single Episode, Unspecified
University of Sao Paulo
 2013-10 PHASE3
NCT01919216 COMPLETED
Major Depressive Disorder
New York State Psychiatric Institute
 2010-01 PHASE4
NCT01594866 COMPLETED
Major Depressive Disorder
Seoul National University Hospital
 2012-05 PHASE4
NCT02469545 COMPLETED
Depression; Anxiety Disorder
Medical University of Bialystok
 2014-06 PHASE2
NCT02272517 COMPLETED
Major Depressive Disorder
H. Lundbeck A/S
 2014-12 PHASE3
NCT01742832 COMPLETED
Major Depressive Disorder
University of Chicago
 2013-05 PHASE2
NCT01667744 WITHDRAWN
Acute Coronary Syndrome
Henry Ford Health System
 2016-01-01 PHASE1; PHASE2
NCT02080832 COMPLETED
Cocaine Dependence
Virginia Commonwealth University
 2010-02 PHASE2
NCT01658228 COMPLETED
Depression; Mild Cognitive Impairment
New York State Psychiatric Institute
 2011-09 PHASE4
NCT03278938 WITHDRAWN
Depressive Illness
New York State Psychiatric Institute
 2012-06-29 PHASE4
NCT00584571 COMPLETED
Rectal Hypersensitivity; Irritable Bowel Syndrome-Constipation
Augusta University
 2007-12 PHASE2
NCT02423694 UNKNOWN
Perimenopause; Depression
Guangdong Provincial Hospital of Traditional Chinese Medicine
 2013-09
NCT01557946 COMPLETED
MDD; Citalopram; Major Depressive Disorder
Mclean Hospital
 2012-03 PHASE4
NCT00834834 COMPLETED
Borderline Personality Disorder; Suicide
New York State Psychiatric Institute
 2009-03 PHASE4
NCT02082392 COMPLETED
Major Depressive Disorder
New York State Psychiatric Institute
 2012-09 PHASE4
NCT01324700 COMPLETED
Depression; Asthma
University of Texas Southwestern Medical Center
 2010-07 PHASE4
NCT01538693 COMPLETED
Spinal Cord Injury
T. George Hornby
 2011-12
NCT00926835 TERMINATED
Major Depressive Disorder
Ministry of Health & Welfare, Korea
 2009-05 PHASE4
NCT01870843 COMPLETED
Depressive Disorder, Major
Xian-Janssen Pharmaceutical Ltd.
 2014-03 PHASE4
NCT00360399 COMPLETED
Depression
Emory University
 2006-08
NCT02028026 WITHDRAWN
Major Depressive Disorder; Anxiety; Comorbidity
Massachusetts General Hospital
 2013-04 PHASE4
NCT01179568 COMPLETED
Complicated Grief; Bereavement
New York State Psychiatric Institute
 2010-03 PHASE2
NCT02800577 COMPLETED
Depression
P1vital Products Limited
 2014-06 PHASE1
NCT01628783 UNKNOWN
Depression
Jesper Ekelund
 2012-06 PHASE4
NCT02092974 COMPLETED
Healthy Young and Older Adults
Charite University, Berlin, Germany
 2014-04 PHASE1
NCT01278498 UNKNOWN
Depression
Asan Medical Center
 2011-01 PHASE4
NCT02237937 UNKNOWN
Major Depression
HolsboerMaschmeyer NeuroChemie GmbH
 2011-09 PHASE4
NCT01032083 COMPLETED
Schizophrenia
Imperial College London
 2011-07 PHASE4
NCT00660062 TERMINATED
Major Depression
Hillerod Hospital, Denmark
 2009-08 PHASE4
NCT02072278 COMPLETED
Healthy Men
H. Lundbeck A/S
 2014-02 PHASE1
NCT01764867 UNKNOWN
Major Depressive Disorder
Shanghai Mental Health Center
 2012-06 PHASE4
NCT02175602 COMPLETED
Hepatitis C Infection
Bristol-Myers Squibb
 2014-06 PHASE1
NCT01251471 COMPLETED
Depression
Medical University of Vienna
 2011-08 PHASE4
NCT00562861 COMPLETED
Bipolar Disorder; Bipolar Depression
Tufts Medical Center
 2007-11 PHASE2; PHASE3
NCT01841125 COMPLETED
Alzheimer's Disease
Konkuk University Medical Center
 2011-11 PHASE4
NCT02000726 WITHDRAWN
Depression
University of Michigan
 2013-07 PHASE2
NCT01871701 COMPLETED
Healthy
Seoul National University Hospital
 2012-11 PHASE1
NCT00974155 COMPLETED
Depression
K. Lieb
 2009-09 PHASE4
NCT01978782 COMPLETED
HIV; Depression
Radboud University Medical Center
 2014-01 PHASE1
NCT02179268 COMPLETED
Bone Mineral Density Quantitative Trait Locus 7
Guiyang Medical University
 2012-03 PHASE3
NCT02122939 COMPLETED
Healthy
Seoul National University Hospital
 2013-09 PHASE1
NCT01008098 UNKNOWN
Posttraumatic Stress Disorder
Seoul National University Hospital
 2008-11 PHASE2
NCT01364649 COMPLETED
Treatment Outcome
Takeda
 2011-06 PHASE3
NCT01778686 COMPLETED
Healthy
Gitte Moos Knudsen
 2013-01
NCT00896441 TERMINATED
Depression; Mood Disorders; Depressive Disorder
Stanford University
 2009-02
NCT01741142 TERMINATED
Major Depressive Disorder
AbbVie (prior sponsor, Abbott)
 2012-01 PHASE2
NCT00485888 COMPLETED
Social Anxiety Disorder
START Clinic for Mood and Anxiety Disorders
 2008-10 PHASE2
NCT01271244 COMPLETED
PTSD
VA Nebraska Western Iowa Health Care System
 2008-06 PHASE4
NCT00517764 COMPLETED
Depression
Centre for Addiction and Mental Health
 2006-12
NCT00613470 COMPLETED
Depression
Mayo Clinic
 2005-03 PHASE1
NCT01219686 TERMINATED
Unipolar Depression
Markus KOSEL
 2010-10 PHASE2; PHASE3
NCT01587326 UNKNOWN
Depression
Beitou Armed Forces Hospital, Taipei, Taiwan
 2012-04
NCT01430520 COMPLETED
Postoperative Pain
Hvidovre University Hospital
 2011-09 PHASE4
NCT02246244 COMPLETED
ENT Cancer
Gustave Roussy, Cancer Campus, Grand Paris
 2009-04 PHASE3
NCT00149799 COMPLETED
Anxiety Disorders; Somatoform Disorders
Massachusetts General Hospital
 2005-05 PHASE3
NCT00419471 COMPLETED
Depressive Disorder; Coronary Disease
Chonnam National University Hospital
 2007-05 PHASE4
NCT01716221 COMPLETED
Friedreich Ataxia
University of Colorado, Denver
 2012-10 PHASE4
NCT00732901 COMPLETED
Cocaine Dependence
Virginia Commonwealth University
 2008-06 PHASE2; PHASE3
NCT01198795 COMPLETED
Major Depressive Disorder
Forest Laboratories
 2010-09 PHASE4
NCT00602290 COMPLETED
Depression
University of California, Los Angeles
 2008-02 PHASE4
NCT01363310 TERMINATED
Depression With Prominent Agitation
Physicians Research And Education Network
 2010-10 PHASE3
NCT00955474 TERMINATED
Major Depressive Disorder With Psychotic Features
Massachusetts General Hospital
 2008-09 PHASE4
NCT01568684 WITHDRAWN
Depressive Disorder; Depressive Disorder, Major; Depression
National Institute of Mental Health (NIMH)
 2012-03-12 PHASE1
NCT01368432 COMPLETED
TBI; Major Depression; Other Psychiatric Disorders
Johns Hopkins University
 2010-04 PHASE2
NCT00707863 COMPLETED
Major Depression
Indiana University
 2008-05 PHASE4
NCT00851006 COMPLETED
Major Depressive Disorder
University of Utah
 2009-04 PHASE2
NCT00227292 WITHDRAWN
Low Back Pain; Depression
Martin-Luther-Universität Halle-Wittenberg
 2007-11 PHASE4
NCT01312922 COMPLETED
Major Depressive Disorder
PharmaNeuroBoost N.V.
 2011-09 PHASE3
NCT01082237 COMPLETED
Major Depressive Disorder
University of California, Los Angeles
 2009-10 PHASE4
NCT00876226 WITHDRAWN
Short Bowel Syndrome
University of Nebraska
 2010-05-01
NCT01154647 UNKNOWN
Fatigue Syndrome, Chronic; Fibromyalgia; Arthritis, Rheumatoid
Vrije Universiteit Brussel
 2010-09
NCT01254305 COMPLETED
Major Depressive Disorder
Forest Laboratories
 2011-04 PHASE2
NCT01368068 TERMINATED
Perimenopausal Depression
The Alfred
 2012-07 PHASE4
NCT00536172 COMPLETED
Depression
University of Nebraska
 2007-12-01 PHASE4
NCT00930293 COMPLETED
Depression; Anxiety
University of Pittsburgh
 2009-07
NCT01153165 UNKNOWN
Asthma
Liam Heaney
 2010-11
NCT02480400 COMPLETED
Major Depressive Disorder
Abarbanel Mental Health Center
 2010-06
NCT01725048 COMPLETED
Major Depressive Disorder; Neoplasms
UNC Lineberger Comprehensive Cancer Center
 2011-01 EARLY_PHASE1
NCT00917059 COMPLETED
Depression
University of California, Los Angeles
 2009-05 PHASE4
NCT00456014 COMPLETED
Depression
New York State Psychiatric Institute
 2006-09
NCT00317746 COMPLETED
Depression; HIV Infections; Hepatitis C
Marina Klein
 2006-11 PHASE3
NCT01814085 COMPLETED
Major Depressive Disorder
Xian-Janssen Pharmaceutical Ltd.
 2010-02 PHASE4
NCT00693732 COMPLETED
Irritable Bowel Syndrome
National University Hospital, Singapore
 2009-02 PHASE4
NCT00989053 UNKNOWN
Depression; Anxiety; In Vitro Fertilization
Tel-Aviv Sourasky Medical Center
 2010-01
NCT01032018 COMPLETED
Acute Coronary Syndrome; Depression
Columbia University
 2010-01 PHASE1; PHASE2
NCT01214044 COMPLETED
Depression
Oregon Health and Science University
 2008-05
NCT04355455 COMPLETED
Gastroesophageal Reflux
Universitaire Ziekenhuizen KU Leuven
 2011-07
NCT01300364 UNKNOWN
Schizophrenia
Fundació Sant Joan de Déu
 2008-11 PHASE4
NCT00386893 WITHDRAWN
Depression
Ludwig-Maximilians - University of Munich
 2006-10 PHASE4
NCT00574847 COMPLETED
Myocardial Ischemia
Duke University
 2006-09 PHASE4
NCT00935246 UNKNOWN
Depression; Continuous Antidepressant Abuse; Adverse Reaction to Drug
Samsung Medical Center
 2008-12
NCT01404871 COMPLETED
Obsessive Compulsive Disorder
Sunnybrook Health Sciences Centre
 2009-04
NCT01109030 COMPLETED
Major Depressive Disorder
Tehran University of Medical Sciences
 2010-04 PHASE2; PHASE3
NCT01111552 TERMINATED
Major Depressive Disorder (MDD)
Otsuka Pharmaceutical Development & Commercialization, Inc.
 2010-07-29 PHASE3
NCT01123707 TERMINATED
Major Depressive Disorder (MDD)
Otsuka Pharmaceutical Development & Commercialization, Inc.
 2010-11-18 PHASE3
NCT01111539 TERMINATED
Major Depressive Disorder (MDD)
Otsuka Pharmaceutical Development & Commercialization, Inc.
 2010-07-13 PHASE3
NCT01111565 TERMINATED
Major Depressive Disorder (MDD)
Otsuka Pharmaceutical Development & Commercialization, Inc.
 2010-10-04 PHASE3
NCT01418274 COMPLETED
Healthy Volunteer
Hoffmann-La Roche
 2011-08 PHASE1
NCT01401595 COMPLETED
Night Eating Syndrome
University of Pennsylvania
 2009-12 PHASE3
NCT00601965 COMPLETED
Generalized Anxiety Disorder
Veterans Medical Research Foundation
 2007-10
NCT00702780 COMPLETED
Alzheimer's Disease
Seoul National University Hospital
 2008-11
NCT01367756 COMPLETED
Healthy Volunteer
Hoffmann-La Roche
 2011-05 PHASE1
NCT00367341 COMPLETED
Major Depressive Disorder
Emory University
 2006-08
NCT00404755 COMPLETED
Major Depressive Disorder; Dysthymia
New York State Psychiatric Institute
 2006-07 PHASE4
NCT00226694 COMPLETED
Alcoholism; Stress; Alcohol Dependence
University of Cincinnati
 2003-09
NCT00977353 COMPLETED
Major Depressive Disorder; Depression; Major Depression
China Medical University Hospital
 2009-04 PHASE2
NCT01601730 COMPLETED
Cocaine Dependence; Cocaine Abuse; Cocaine Addiction; Substance Abuse
Baylor College of Medicine
 2010-08 PHASE1
NCT00519428 COMPLETED
Major Depressive Disorder
New York State Psychiatric Institute
 2007-08 PHASE4
NCT01398514 COMPLETED
Fear Conditioning
Massachusetts General Hospital
 2008-10 PHASE4
NCT01045083 COMPLETED
Healthy Volunteer
Hoffmann-La Roche
 2010-01 PHASE1
NCT00488670 TERMINATED
Depressive Disorder
University of British Columbia
 2010-12 PHASE3
NCT00703742 COMPLETED
Depression; Depression Secondary to Other Disease
Kunming Medical University
 2008-06
NCT00220480 UNKNOWN
Depressive Disorder, Major
Sheba Medical Center
 2005-02
NCT01814098 COMPLETED
Depressive Disorder, Major
Xian-Janssen Pharmaceutical Ltd.
 2009-07-07 PHASE4
NCT00872027 COMPLETED
Depression
University of Minnesota
 2009-04 PHASE4
NCT01099592 TERMINATED
Acute Coronary Syndrome; Major Depressive Episode
Centre hospitalier de l'Université de Montréal (CHUM)
 2010-11 PHASE4
NCT00702598 COMPLETED
Major Depressive Disorder (MDD)
University of British Columbia
 2008-06
NCT00387348 TERMINATED
Colorectal Cancer; Depression; Esophageal Cancer; Extrahepatic Bile Duct Cancer; Fatigue; Gallbladder Cancer; Gastric Cancer; Liver Cancer; Lung Cancer; Pancreatic Cancer
Massachusetts General Hospital
 2006-03 PHASE3
NCT00825825 COMPLETED
Antidepressant Activity in Healthy Volunteers
Michael Henry, MD
 2007-05 PHASE4
NCT00833469 COMPLETED
Postpartum Depression
Massachusetts General Hospital
 2009-01 PHASE4
NCT01101685 COMPLETED
Dysphoria
University of Oxford
 2010-02 PHASE4
NCT01034995 COMPLETED
Major Depression
Sanofi
 2010-02 PHASE2
NCT00824044 COMPLETED
Major Depressive Disorder
Massachusetts General Hospital
 2008-07 PHASE4
NCT01638689 COMPLETED
Healthy
Karolinska Institutet
 2010-09 PHASE1
NCT00243477 COMPLETED
Coronary Artery Disease
Hopital Jean Minjoz
 2006-01 PHASE4
NCT01541475 COMPLETED
Major Depressive Disorder
Ewha Womans University
 2009-03 PHASE4
NCT00723060 COMPLETED
Obsessive Compulsive Disorder
Seoul National University Hospital
 2008-09 PHASE4
NCT00254020 COMPLETED
Depression
Sunnybrook Health Sciences Centre
 2005-06 PHASE4
NCT01078870 UNKNOWN
Schizophrenia
National Taiwan University Hospital
 2010-02 PHASE4
NCT01189812 COMPLETED
Major Depressive Disorder; Dysthymia; Depression Not Otherwise Specified; Borderline Personality Disorder
Columbia Northwest Pharmaceuticals
 2010-03 PHASE2
NCT00985504 COMPLETED
Major Depressive Disorder
Eli Lilly and Company
 2009-09 PHASE4
NCT00594269 COMPLETED
Dementia
Sykehuset Innlandet HF
 2008-08 PHASE4
NCT01090700 COMPLETED
Hepatitis C Virus
Tibotec Pharmaceuticals, Ireland
 2010-05 PHASE1
NCT00754793 TERMINATED
Chronic Sinusitis; Facial Pain Disorder; Depression
University of Washington
 2009-01 PHASE4
NCT00636649 COMPLETED
Night Eating Syndrome
Duke University
 2008-10
NCT00708240 UNKNOWN
Obsessive Compulsive Disorder
University of Ottawa
 2007-01 PHASE4
NCT00967408 UNKNOWN
Stroke
Azienda Ospedaliero Universitaria Maggiore della Carita
 2009-07 PHASE4
NCT00708396 UNKNOWN
OCD; Schizophrenia
BeerYaakov Mental Health Center
 2008-07 PHASE4
NCT00070941 COMPLETED
Parkinson's Disease; Depression
NYU Langone Health
 2003-07 PHASE2; PHASE3
NCT00101452 COMPLETED
Depression
Maurizio Fava, MD
 2005-04
NCT01745601 COMPLETED
Anxiety Disorders
GlaxoSmithKline
 2010-05-04 PHASE1
NCT00452543 COMPLETED
Major Depressive Disorder; Alcohol Abuse; Alcohol Dependence
Massachusetts General Hospital
 2007-03 PHASE4
NCT01951053 COMPLETED
Healthy
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
 2010-01 PHASE1
NCT00642694 TERMINATED
Major Depressive Disorder; Insomnia
University of Texas Southwestern Medical Center
 2007-05 PHASE3
NCT00918684 COMPLETED
Depression
Weill Medical College of Cornell University
 2002-12 PHASE4
NCT01020799 COMPLETED
Major Depressive Disorder
AstraZeneca
 2009-11 PHASE2
NCT00613067 COMPLETED
Generalized Anxiety Disorder
Inje University
 2007-12
NCT01119638 COMPLETED
Agitation; Psychosis; Alzheimer's Disease
Abarbanel Mental Health Center
 2008-04 PHASE4
NCT00962039 COMPLETED
Abdominal Pain; Anxiety
John V. Campo, M.D.
 2004-07 PHASE2; PHASE3
NCT00837564 UNKNOWN
Chronic Depression
University Hospital Freiburg
 2009-02 PHASE3
NCT00621946 COMPLETED
Severe Asthma; Moderate or Severe Major Depressive Disorder
University of Texas Southwestern Medical Center
 2008-03 PHASE4
NCT00736021 COMPLETED
Stress Disorders, Post Traumatic
Hadassah Medical Organization
 2008-09
NCT01876823 COMPLETED
Mild Cognitive Impairment; Major Depressive Disorder; Alzheimer's Disease
New York State Psychiatric Institute
 2006-04 PHASE2; PHASE3
NCT00810069 COMPLETED
Major Depressive Disorder
Eli Lilly and Company
 2008-11 PHASE4
NCT00822744 COMPLETED
Major Depressive Disorder
Sanofi
 2008-12 PHASE2
NCT00218036 TERMINATED
Cocaine Abuse; Opiate Dependence
The University of Texas Health Science Center, Houston
 2006-07 PHASE2
NCT00145132 COMPLETED
Depression
Ludwig-Maximilians - University of Munich
 2005-06 PHASE4
NCT00807248 COMPLETED
Major Depressive Disorder
H. Lundbeck A/S
 2008-11 PHASE2
NCT00838305 COMPLETED
MDMA Mechanism of Action
California Pacific Medical Center Research Institute
 2009-02
NCT00902226 COMPLETED
Social Anxiety Disorder
H. Lundbeck A/S
 2009-03 PHASE4
NCT00785434 COMPLETED
Major Depressive Disorder
Community Pharmacology Services Ltd
 2008-10 PHASE4
NCT00902564 COMPLETED
Generalized Anxiety Disorder
H. Lundbeck A/S
 2009-03 PHASE4
NCT00933894 COMPLETED
Hepatitis C
Tibotec BVBA
 2009-09 PHASE1
NCT00628914 UNKNOWN
Major Depressive Disorder; Insomnia
University of California, Los Angeles
 2008-05 PHASE4
NCT00343070 COMPLETED
Major Depression
University Hospital, Ghent
 2007-03 PHASE2
NCT00523705 TERMINATED
PMS
University of Pennsylvania
 2008-02 PHASE4
NCT00475878 COMPLETED
Opiate Dependence; Depression
Butler Hospital
 2006-12 PHASE3
NCT00464711 COMPLETED
Major Depressive Disorder
Massachusetts General Hospital
 2006-09 PHASE4
NCT00887679 COMPLETED
Anxiety Disorders; HIV Infections
Duke University
 2009-05 PHASE3
NCT00177671 COMPLETED
Depression; Dementia
University of Pittsburgh
 2003-12 PHASE4
NCT00590863 COMPLETED
Major Depressive Disorder
National Institute of Mental Health (NIMH)
 2008-03 PHASE4
NCT00609531 COMPLETED
Autism Spectrum Disorders
University of North Carolina, Chapel Hill
 2007-01 PHASE1
NCT00177294 COMPLETED
Depression
University of Pittsburgh
 2004-04 PHASE4
NCT00655057 COMPLETED
Depression
University of Pennsylvania
 2005-10 PHASE2; PHASE3
NCT00376051 COMPLETED
Frontotemporal Dementia
Sunnybrook Health Sciences Centre
 2006-09 PHASE4
NCT00209807 UNKNOWN
Major Depression; Pain; Abdominal Pain
Hospital Universitari Vall d'Hebron Research Institute
 2005-09 PHASE4
NCT00200902 COMPLETED
Depression
University of California, Los Angeles
 2005-08 PHASE4
NCT00477165 COMPLETED
Irritable Bowel Syndrome
Stanford University
 2001-04 PHASE2
NCT00183677 COMPLETED
Depression
Massachusetts General Hospital
 2003-07 PHASE4
NCT00386841 COMPLETED
Healthy
University of Copenhagen
 2007-04 PHASE4
NCT00300313 COMPLETED
Post-traumatic Stress Disorder
Sheba Medical Center
 2005-06
NCT00692445 COMPLETED
Major Depressive Disorder; Depression
Targacept Inc.
 2008-06 PHASE2
NCT01527474 COMPLETED
Postpartum Depression
BC Women's Hospital & Health Centre
 2008-04
NCT01424384 COMPLETED
Depressive Disorder and Anxiety Disorders
GlaxoSmithKline
 2008-09-19 PHASE1
NCT01797380 TERMINATED
Depression; HIV
Duke University
 2008-01 PHASE4
NCT00464191 TERMINATED
Bipolar Disorder
Nordfjord Psychiatric Centre
 2006-04 PHASE4
NCT00813735 COMPLETED
Insomnia
Lehigh Center for Clinical Research
 2006-09 PHASE4
NCT00666757 COMPLETED
Depression
Eli Lilly and Company
 2008-05 PHASE4
NCT00166114 COMPLETED
Major Depressive Disorder
Emory University
 2002-02 PHASE4
NCT00672659 COMPLETED
Depression
PharmaNeuroBoost N.V.
 2008-02 PHASE2
NCT00215137 COMPLETED
OCD
Duke University
 2004-10 PHASE2
NCT00531622 COMPLETED
Major Depressive Disorder
Sanofi
 2007-09 PHASE3
NCT00232700 COMPLETED
Major Depressive Disorder
Charite University, Berlin, Germany
 2005-09
NCT00140257 UNKNOWN
Depression
Bispebjerg Hospital
 2004-11 PHASE4
NCT00656552 UNKNOWN
Premature Ejaculation
Cairo University
 2008-05 EARLY_PHASE1
NCT00566202 COMPLETED
Major Depressive Disorder
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
 2007-12 PHASE2
NCT00220701 COMPLETED
Dysthymic Disorder
St. Luke's-Roosevelt Hospital Center
 2002-06 PHASE4
NCT00598052 UNKNOWN
Marijuana Dependence
Tel-Aviv Sourasky Medical Center
 2007-12
NCT00188396 COMPLETED
Major Depressive Disorder; Depression
University Health Network, Toronto
 2004-04
NCT00456937 COMPLETED
Schizophrenia
BeerYaakov Mental Health Center
 2006-07 PHASE4
NCT00680602 COMPLETED
Obsessive Compulsive Disorder
University of Sao Paulo
 2006-01 PHASE4
NCT00136318 COMPLETED
Depression
Charite University, Berlin, Germany
 2004-01 PHASE3
NCT00993876 COMPLETED
Cognitive Performance in Major Depression
Zentrum für Integrative Psychiatrie
 2005-08
NCT00676039 COMPLETED
Healthy
University of Ottawa
 2007-11 PHASE1
NCT00219349 COMPLETED
Generalized Anxiety Disorder
New York State Psychiatric Institute
 2005-01 PHASE4
NCT00295347 COMPLETED
Major Depression
Universitätsklinikum Hamburg-Eppendorf
 2005-12
NCT00133276 COMPLETED
Hepatitis C
Foundation for Liver Research
 2005-08 PHASE2; PHASE3
NCT00162916 UNKNOWN
Depression
Ontario Neurotrauma Foundation
 2005-05 PHASE4
NCT00209170 COMPLETED
Diabetes; Depression
Emory University
 2004-05 PHASE4
NCT00177216 COMPLETED
Sleep Disorders
University of Pittsburgh
 2002-02 PHASE4
NCT00774813 COMPLETED
Depression
Kalaco Scientific, Inc.
 2007-10 PHASE2
NCT01996462 COMPLETED
Healthy
Torrent Pharmaceuticals Limited
 PHASE1
NCT01996475 COMPLETED
Healthy
Torrent Pharmaceuticals Limited
 PHASE1
NCT00417118 COMPLETED
Generalized Anxiety
Sanofi
 2006-12 PHASE3
NCT00420004 COMPLETED
Major Depressive Disorder
Eli Lilly and Company
 2006-12 PHASE2
NCT00481325 COMPLETED
Generalized Anxiety Disorder
Bristol-Myers Squibb
 2007-07 PHASE2; PHASE3
NCT00415142 COMPLETED
Depressive Disorder
Sanofi
 2006-12 PHASE3
NCT00406640 COMPLETED
Depression; Depressive Disorder; Depressive Disorder, Major
Wyeth is now a wholly owned subsidiary of Pfizer
 2006-12 PHASE3
NCT00105586 COMPLETED
Anxiety Disorders; Generalized Anxiety Disorder
University of Pittsburgh
 2004-12 PHASE4
NCT00146900 COMPLETED
Post-traumatic Stress Disorder
Hadassah Medical Organization
 2004-08
NCT03927950 COMPLETED
Major Depression
University of Tartu
 2007-01 PHASE4
NCT00358631 COMPLETED
Depressive Disorder
Sanofi
 2006-07 PHASE2
NCT00166296 COMPLETED
Major Depressive Disorder; Hepatitis C, Chronic
Germans Trias i Pujol Hospital
 2005-03 PHASE2
NCT00073697 COMPLETED
Depression
University of Pittsburgh
 2003-05 PHASE4
NCT00397059 COMPLETED
Healthy
University of Southern Denmark
 2006-12 PHASE4
NCT00384436 COMPLETED
Major Depressive Disorder
Forest Laboratories
 2006-10 PHASE4
NCT00893256 COMPLETED
Schizophrenia; Negative Symptoms
National Institute of Mental Health and Neuro Sciences, India
 2004-12 PHASE4
NCT01575158 COMPLETED
Depression
University of Aarhus
 1997-10
NCT00149825 COMPLETED
Major Depressive Disorder; Insomnia
Stanford University
 2004-06 PHASE2
NCT00456430 COMPLETED
Depression
Indiana University
 2003-07 PHASE4
NCT00296179 COMPLETED
Insomnia
Sanofi
 2006-02 PHASE4
NCT00363909 COMPLETED
Breast Cancer; Hot Flashes; Psychosocial Effects of Cancer and Its Treatment
Alliance for Clinical Trials in Oncology
 2006-11 PHASE3
NCT00375843 COMPLETED
Depression
National Institute of Mental Health (NIMH)
 2005-01 PHASE4
NCT00610506 COMPLETED
Atypical Depression
Duke University
 2005-10 PHASE3
NCT00296777 COMPLETED
Major Depression; Dysthymia
New York State Psychiatric Institute
 2004-12 PHASE4
NCT00048815 COMPLETED
Depression
Massachusetts General Hospital
 2003-02
NCT00277108 COMPLETED
Postpartum Depression
University of Rochester
 2004-02
NCT00067301 COMPLETED
Major Depression
National Center for Complementary and Integrative Health (NCCIH)
 2003-09 PHASE3
NCT00194948 COMPLETED
Major Depression
Weill Medical College of Cornell University
 2003-09
NCT00018902 COMPLETED
Depression
University of Pittsburgh
 2001-01 PHASE2; PHASE3
NCT00252343 COMPLETED
Anxiety Disorder
Sanofi
 2005-09 PHASE3
NCT00252356 COMPLETED
Major Depressive Disorder
Sanofi
 2005-09 PHASE3
NCT00252330 COMPLETED
Major Depressive Disorder
Sanofi
 2005-09 PHASE3
NCT00260624 COMPLETED
Alzheimer's Disease; Psychomotor Agitation
University of Rochester
 2003-02 PHASE4
NCT00047671 COMPLETED
Depression
National Institute of Mental Health (NIMH)
 2002-06 PHASE4
NCT00361790 COMPLETED
Healthy
Otsuka Pharmaceutical Development & Commercialization, Inc.
 2006-08 PHASE1
NCT00086645 COMPLETED
Autistic Disorder
Boston University
 2004-04 PHASE2
NCT00234312 COMPLETED
Depression; Dysthymia
Oregon Health and Science University
 2005-09 PHASE4
NCT00047450 COMPLETED
Schizophrenia
Veterans Medical Research Foundation
 2001-09
NCT01148472 COMPLETED
Major Depressive Disorder
H. Lundbeck A/S
 2005-09 PHASE4
NCT00296712 COMPLETED
Major Depression; Dysthymia; Depression NOS
New York State Psychiatric Institute
 2005-02 PHASE4
NCT00221494 WITHDRAWN
Depression
Mark Frye
 2004-01 PHASE4
NCT00206934 COMPLETED
Healthy Volunteers
University of Copenhagen
 2005-03
NCT00254007 COMPLETED
Depression; Traumatic Brain Injury
Sunnybrook Health Sciences Centre
 2003-07 PHASE4
NCT00073658 COMPLETED
Dementia
University of Pittsburgh
 2000-01 PHASE2
NCT00931775 COMPLETED
Major Depressive Disorder; Antidepressant Treatment Response
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
 2002-12 PHASE2
NCT00648661 COMPLETED
Healthy
Mylan Pharmaceuticals Inc
 2004-09 PHASE1
NCT00648570 COMPLETED
Healthy
Mylan Pharmaceuticals Inc
 2004-08 PHASE1
NCT00051272 COMPLETED
Major Depressive Disorder (MDD)
GlaxoSmithKline
 2003-01 PHASE3
NCT00051259 COMPLETED
Major Depressive Disorder (MDD)
GlaxoSmithKline
 2003-01 PHASE3
NCT01149967 COMPLETED
Healthy
Dr. Reddy's Laboratories Limited
 2003-10 PHASE1
NCT01149980 COMPLETED
Healthy
Dr. Reddy's Laboratories Limited
 2003-10 PHASE1
NCT00865943 COMPLETED
Healthy
Actavis Inc.
 2003-07 PHASE1
NCT00864890 COMPLETED
Healthy
Actavis Inc.
 2003-06 PHASE1
NCT00865085 COMPLETED
Healthy
Actavis Inc.
 2003-06 PHASE1
NCT00217828 COMPLETED
Cardiovascular Diseases; Heart Diseases
University of Pittsburgh
 2002-03
NCT00009204 COMPLETED
Dementia; Alzheimer Disease; Dementia, Vascular
Bruce Pollock
 1995-09 PHASE3
NCT00149071 COMPLETED
Major Depression
Hillerod Hospital, Denmark
 2004-03
NCT00162968 COMPLETED
Pain; Polyneuropathies
Odense University Hospital
 2004-12 PHASE4
NCT01522092 WITHDRAWN
Anxiety; COPD
Hull University Teaching Hospitals NHS Trust
 PHASE3
NCT00121069 COMPLETED
Phobic Disorders
Connor, Kathryn M., M.D.
 2002-09 PHASE2; PHASE3
NCT00239954 UNKNOWN
Major Depressive Disorder
Pharmacology Research Institute
 2005-03 PHASE3
NCT00249886 WITHDRAWN
Major Depression
Sunnybrook Health Sciences Centre
 2002-09 PHASE3
NCT00269334 UNKNOWN
Major Depression
National Health Research Institutes, Taiwan
 2005-12 PHASE4
NCT00329446 COMPLETED
Generalized Anxiety Disorder
AstraZeneca
 2006-04 PHASE3
NCT00296790 COMPLETED
Insomnia
Sanofi
 2006-02 PHASE4
NCT00297505 COMPLETED
Cocaine Dependence
National Institute on Drug Abuse (NIDA)
 2001-04 PHASE2
NCT00433121 COMPLETED
Dementia
Sykehuset Innlandet HF
 2006-09 PHASE4
NCT00296933 COMPLETED
Depression; Major Depressive Disorder
University Health Network, Toronto
 2005-12 PHASE3
NCT00215228 COMPLETED
Major Depressive Disorder
Duke University
 2005-07 PHASE2; PHASE3
NCT00114374 TERMINATED
Anxiety Disorder
Massachusetts General Hospital
 2005-06 PHASE3
NCT00130455 TERMINATED
Depression
Psychiatric Hospital, Hillerod
 2006-04 PHASE4
NCT00351910 COMPLETED
Major Depressive Disorder
AstraZeneca
 2006-05 PHASE3
NCT00255554 UNKNOWN
Borderline Personality Disorder
Bronx VA Medical Center
NCT00368862 COMPLETED
Alcoholism; Depression
Finnish Institute for Health and Welfare
 2005-12 PHASE4
NCT00208572 UNKNOWN
Traumatic Brain Injury
Walter Reed Army Medical Center
 2003-11
NCT00538889 COMPLETED
Healthy
Wyeth is now a wholly owned subsidiary of Pfizer
 2007-08 PHASE1
NCT00414323 COMPLETED
Major Depressive Disorder
Eli Lilly and Company
 2006-11 PHASE1
NCT00021528 COMPLETED
Depression
National Institute of Mental Health (NIMH)
 2001-07 PHASE4
NCT00416221 COMPLETED
Depression
University of California, San Diego
 2006-04
NCT00935675 UNKNOWN
Carcinomas
Gustave Roussy, Cancer Campus, Grand Paris
 PHASE3
NCT00532519 UNKNOWN
Prurigo Nodularis
Hadassah Medical Organization
NCT00015548 COMPLETED
Alzheimer's Disease
National Institute of Mental Health (NIMH)
 2001-03
NCT00231335 COMPLETED
Schizophrenia; Schizoaffective Disorder
Emory University
 2006-03 PHASE4
NCT00151294 TERMINATED
Depression; Multiple Sclerosis
Weill Medical College of Cornell University
 2004-11 PHASE4
NCT00174603 TERMINATED
Major Depression With Psychotic Features
Rush University Medical Center
 2005-08 PHASE3
NCT00593879 COMPLETED
Major Depressive Disorder
Targacept Inc.
 2005-02 PHASE2
NCT00305500 COMPLETED
Obsessive-Compulsive Disorder
Abarbanel Mental Health Center
 2006-03 PHASE3
NCT00156325 COMPLETED
Bipolar Disorders
The University of New South Wales
 2004-02 PHASE2
NCT00940238 COMPLETED
Healthy
Torrent Pharmaceuticals Limited
 PHASE1
NCT00222820 COMPLETED
Major Depression
University of Pittsburgh
 2002-04 PHASE4
NCT00080158 COMPLETED
Depression; Suicide, Attempted
New York State Psychiatric Institute
 2004-03 PHASE2; PHASE3
NCT00116532 COMPLETED
Obsessive Compulsive Disorder
Massachusetts General Hospital
 2002-10 PHASE4
NCT00351169 COMPLETED
Major Depressive Disorder
AstraZeneca
 2006-05 PHASE3
NCT00115011 COMPLETED
Impulse Control Disorders
Massachusetts General Hospital
 2002-09 PHASE4
NCT00073411 COMPLETED
Depression
Eli Lilly and Company
 2003-11 PHASE3
NCT00442481 UNKNOWN
Major Depressive Disorder
Sheba Medical Center
 2007-02 PHASE4
NCT00423969 TERMINATED
Depression
Indiana University
 2003-11 PHASE4
NCT00070694 COMPLETED
Depressive Disorder
National Institute of Mental Health (NIMH)
 2003-09 PHASE2

(data from https://clinicaltrials.gov, updated on 2025-12-16)

Check the Citalopram HBr product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Citalopram HBr selectively binds to the presynaptic serotonin transporter with an IC50 of 1.8 nM, which blocks the reuptake of serotonin into presynaptic terminals and elevates extracellular neurotransmitter concentrations in the synaptic cleft. This accumulation enhances central serotonergic signaling and downstream neurochemical pathways, providing the mechanistic foundation for treating major depressive disorder, obsessive-compulsive disorder, and related conditions evaluated in clinical trials.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.